Patents by Inventor Brian D. Brohman

Brian D. Brohman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250102482
    Abstract: Disclosed herein are methods of preparing and analyzing samples for biomarkers associated with placenta accreta in pregnant subjects. Also disclosed are method of assessing the risk of placenta accreta in pregnant subjects.
    Type: Application
    Filed: November 14, 2022
    Publication date: March 27, 2025
    Inventors: Thomas F. McELRATH, Kevin P. ROSENBLATT, Brian D. BROHMAN, Prem P. GURNANI
  • Publication number: 20240339220
    Abstract: A method for developing a longitudinal predictive model for adverse gestational outcomes comprises receiving pregnancy datasets from discrete data sources for a plurality of subjects having a plurality of gestational outcomes, independently analyzing the discrete datasets to identify biomarkers for the gestational outcomes, combining the biomarkers into a single meta-dataset, and analyzing the meta-dataset to produce a model for the gestational outcome. Models can be generated for a plurality of different timepoints in pregnancy. A pregnant subject can be tracked into one of a plurality of treatment tracks based on predicted risk of an adverse gestational outcome after each episode of testing.
    Type: Application
    Filed: July 13, 2022
    Publication date: October 10, 2024
    Inventors: Thomas F. MCELRATH, Kevin P. ROSENBLATT, Brian D. BROHMAN
  • Publication number: 20240310384
    Abstract: The present disclosure relates to biomarkers of preterm hirth, biomarkers of term hirth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
    Type: Application
    Filed: October 25, 2023
    Publication date: September 19, 2024
    Inventors: Alan M. EZRIN, Brian D. BROHMAN
  • Patent number: 11835530
    Abstract: The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: December 5, 2023
    Assignee: NX Prenatal Inc.
    Inventors: Alan M. Ezrin, Brian D. Brohman
  • Publication number: 20210270840
    Abstract: The present disclosure relates to proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subject's risk for premature delivery.
    Type: Application
    Filed: December 23, 2020
    Publication date: September 2, 2021
    Inventors: Brian D. BROHMAN, Zhen ZHANG, Kevin S. GOUDY, Robert C. DOSS, Alan M. EZRIN, Kevin Paul ROSENBLATT
  • Publication number: 20210231674
    Abstract: The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
    Type: Application
    Filed: January 20, 2021
    Publication date: July 29, 2021
    Inventors: Alan M. EZRIN, Brian D. BROHMAN
  • Publication number: 20210057039
    Abstract: The present disclosure relates to systems and methods of using machine learning analysis to stratify the risk of spontaneous preterm birth (SPTB). In some variations, to select informative markers that differentiate SPTB from term deliveries, a processed quantification data of the markers can be subjected to univariate receiver operating characteristic (ROC) curve analysis. A Differential Dependency Network (DDN) can then applied in order to extract co-expression patterns among the markers. In order to assess the complementary values among selected markers and the range of their relevant performance, multivariate linear models can be derived and evaluated using bootstrap resampling.
    Type: Application
    Filed: July 31, 2020
    Publication date: February 25, 2021
    Inventors: Brian D. BROHMAN, Zhen ZHANG, Robert C. DOSS, Kevin Paul ROSENBLATT
  • Patent number: 10928402
    Abstract: The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: February 23, 2021
    Assignee: NX PRENATAL INC.
    Inventors: Alan M. Ezrin, Brian D. Brohman
  • Publication number: 20210050112
    Abstract: Disclosed herein are methods and systems for determining risk of preeclampsia. The system can include (a) a computer comprising: (i) a processor; and (II) a memory, coupled to the processor, the memory storing a module comprising: (1) test data for a sample from a subject including values indicating a quantitative measure of one or more markers; (2) a classification rule which, based on values including the measurements, classifies the subject as being at risk of preeclampsia, wherein the classification rule is configured to have a sensitivity of at least 75%, at least 85% or at least 95%; and (3) computer executable instructions for implementing the classification rule on the test data.
    Type: Application
    Filed: July 31, 2020
    Publication date: February 18, 2021
    Inventors: Kevin P. ROSENBLATT, Thomas F. MCELRATH, Brian D. BROHMAN, Robert C. DOSS
  • Patent number: 10877046
    Abstract: Provided herein are proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, provided are tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subject's risk for premature delivery.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: December 29, 2020
    Assignee: NX PRENATAL INC.
    Inventors: Brian D. Brohman, Zhen Zhang, Kevin S. Goudy, Robert C. Doss, Alan M. Ezrin, Kevin Paul Rosenblatt
  • Publication number: 20190041391
    Abstract: The present disclosure relates to proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subject's risk for premature delivery.
    Type: Application
    Filed: June 4, 2018
    Publication date: February 7, 2019
    Inventors: Brian D. BROHMAN, Zhen ZHANG, Kevin S. GOUDY, Robert C. DOSS, Alan M. EZRIN, Kevin Paul ROSENBLATT
  • Publication number: 20150355188
    Abstract: The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
    Type: Application
    Filed: December 26, 2013
    Publication date: December 10, 2015
    Inventors: Alan M. EZRIN, Brian D. BROHMAN
  • Publication number: 20140186332
    Abstract: The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
    Type: Application
    Filed: March 12, 2013
    Publication date: July 3, 2014
    Applicant: NX Pharmagen
    Inventors: Alan M. EZRIN, Brian D. Brohman