Abstract: The present invention provides methods for preventing or treating allergy. Also provided are methods for reducing the susceptibility to an allergen in a subject in need thereof. In certain embodiments, the subject has a disease or disorder selected from the group consisting of atopic dermatitis, asthma, allergic rhinitis, and eosinophilic esophagitis. The methods of the present invention comprise administering to a subject in need thereof a pharmaceutical composition comprising an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody.

Abstract: Voltage-to-current converters that include two current mirrors are disclosed. In an example voltage-to-current converter each current mirror is a complementary current mirror in that one of its input and output transistors is a P-type transistor and the other one is an N-type transistor. Such voltage-to-current converters may be implemented using bipolar technology, CMOS technology, or a combination of bipolar and CMOS technologies, and may be made sufficiently compact and accurate while operating at sufficiently low voltages and consuming limited power.

Abstract: In an optical detection system, features of interest can be identified from ADC circuitry data prior to inter-circuit communication with downstream object or target processing circuitry. In this manner, a volume of data being transferred to such downstream processing circuitry can be reduced as compared to other approaches, simplifying the receive signal processing chain and providing power savings. First-tier signal processing circuitry to identify features of interest can be located on or within a commonly-shared integrated circuit package with ADC circuitry, and downstream processing circuitry for object processing or range estimation can be fed with a data link meeting less stringent requirements than a link between the ADC circuitry and first-tier signal processing circuitry.

Abstract: A multi-stage transimpedance amplifier (TIA) with an adjustable input linear range is disclosed. The TIA includes a first stage, configured to convert a single-ended current signal from an optical sensor of a receiver signal chain to a single-ended voltage signal, and a second stage, configured to convert the single-ended voltage signal provided by the first stage to a differential signal. In such a TIA, the input linear range may be adjusted using a clamp that is programmable with an output offset current to keep the second stage of the TIA from overloading and to maintain a linear transfer function without compression.

Abstract: Voltage-to-current converters that include two current mirrors are disclosed. In an example voltage-to-current converter each current mirror is a complementary current mirror in that one of its input and output transistors is a P-type transistor and the other one is an N-type transistor. Such voltage-to-current converters may be implemented using bipolar technology, CMOS technology, or a combination of bipolar and CMOS technologies, and may be made sufficiently compact and accurate while operating at sufficiently low voltages and consuming limited power.

Abstract: A multi-stage transimpedance amplifier (TIA) with an adjustable input linear range is disclosed. The TIA includes a first stage, configured to convert a single-ended current signal from an optical sensor of a receiver signal chain to a single-ended voltage signal, and a second stage, configured to convert the single-ended voltage signal provided by the first stage to a differential signal. In such a TIA, the input linear range may be adjusted using a clamp that is programmable with an output offset current to keep the second stage of the TIA from overloading and to maintain a linear transfer function without compression.

Abstract: In an optical detection system, features of interest can be identified from ADC circuitry data prior to inter-circuit communication with downstream object or target processing circuitry. In this manner, a volume of data being transferred to such downstream processing circuitry can be reduced as compared to other approaches, simplifying the receive signal processing chain and providing power savings.

Abstract: A semiconductor wafer in an intermediate stage of fabrication having an array of slices. All but one of the slices may have integrated circuit components interconnected by metallization layers to form a die having an operable circuit, with the remaining slice functioning as a scribe area or line. Two embodiments of slices are disclosed in which one slice is a rectangle of a minimum width to function as a scribe area, and the other slice is composed of a sliver and a rectangle with the latter also having a minimum width to function as a scribe area. Each embodiment of a slice can be extended lengthwise with an extension box that also can function to contain operative components or function as a scribe area.