Patents by Inventor Brian D. Kelley

Brian D. Kelley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Binding molecules for human factor VIII and factor VIII-like proteins
    Patent number: 9156883
    Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: October 13, 2015
    Assignee: Dyax Corp.
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James E. Booth
  • Method of weak partitioning chromatography
    Patent number: 9144755
    Abstract: This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid containing one or more impurities. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or alternatively, defined by a partition coefficient of at least 0.1.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: September 29, 2015
    Assignee: Wyeth LLC
    Inventors: Paul R. Brown, Jonathan Lee Coffman, Ranganathan Godavarti, Timothy Iskra, Brian D. Kelley, Suresh Vunnum, Shujun Sun, Tianning Yu, James Edward Booth, Mary Beth Switzer
  • BINDING MOLECULES FOR HUMAN FACTOR VIII AND FACTOR VIII-LIKE PROTEINS
    Publication number: 20140221611
    Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
    Type: Application
    Filed: August 14, 2013
    Publication date: August 7, 2014
    Applicant: DYAX CORP.
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James E. Booth
  • Binding molecules for human factor VIII and factor VIII-like proteins
    Patent number: 8535892
    Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: September 17, 2013
    Assignee: Dyax Corp.
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James E. Booth
  • METHOD OF WEAK PARTITIONING CHROMATOGRAPHY
    Publication number: 20120138537
    Abstract: This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid containing one or more impurities. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or alternatively, defined by a partition coefficient of at least 0.1.
    Type: Application
    Filed: November 28, 2011
    Publication date: June 7, 2012
    Applicant: Wyeth LLC
    Inventors: Brian D. Kelley, James E. Booth, Paul Brown, Jon Coffman, Ranganathan Godavarti, Tim Iskra, Shujun Sun, Mary B. Switzer, Suresh Vunnum, Tianning Yu
  • BINDING MOLECULES FOR HUMAN FACTOR VIII AND FACTOR VIII-LIKE PROTEINS
    Publication number: 20120045819
    Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
    Type: Application
    Filed: September 23, 2011
    Publication date: February 23, 2012
    Applicant: DYAX CORP.
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James E. Booth
  • Method of weak partitioning chromatography
    Patent number: 8067182
    Abstract: This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid containing one or more impurities. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or alternatively, defined by a partition coefficient of at least 0.1.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: November 29, 2011
    Assignee: Wyeth LLC
    Inventors: Brian D. Kelley, James E. Booth, Paul Brown, Jon Coffman, Ranganathan Godavarti, Tim Iskra, Shujun Sun, Mary B. Switzer, Suresh Vunnum, Tianning Yu
  • Methods and compositions for purifying human factor VIII, factor VIII-like proteins or fragments thereof
    Patent number: 8058017
    Abstract: Provided herein are methods and compositions for purifying human factor VIII, human factor VIII-like peptide or fragments thereof. The methods comprise immobilizing a binding molecule for human factor VIII, human factor VIII-like protein or fragments thereof to a solid support, contacting the immobilized binding molecule with a solution containing the human factor VIII, human factor VIII-like protein or fragments thereof, and purifying the factor by separating the solution from the solid support.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: November 15, 2011
    Assignee: Dyax Corp.
    Inventors: Jinan Yu, M. Daniel Potter, Marilous Potter, legal representative, Brian D. Kelley, Jeffrey S. Deetz, James E. Booth
  • Binding Molecules for Human Factor VIII and Factor VIII-Like Proteins
    Publication number: 20100292440
    Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
    Type: Application
    Filed: January 22, 2010
    Publication date: November 18, 2010
    Applicant: Dyax Corp.
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James E. Booth, Marilous Potter
  • Methods for producing Factor VIII proteins
    Patent number: 7820796
    Abstract: Methods are provided for purification of Factor VIII polypeptides by affinity chromatography and ion exchange chromatography, in which the eluate from the affinity column is diluted with a solution comprising higher salt concentration, or lower non-polar agent concentration than that of the elution solution, prior to passing the diluted solution through the ion exchange column. The affinity matrix may comprise a monoclonal antibody or a peptide ligand. The methods result in improved purification without significant yield loss.
    Type: Grant
    Filed: January 26, 2005
    Date of Patent: October 26, 2010
    Assignee: Genetics Institute, LLC.
    Inventors: James Booth, Suresh Vunnum, Brian D. Kelley
  • Binding molecules for human factor VIII and factor VIII-like proteins
    Patent number: 7691565
    Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: April 6, 2010
    Assignee: Dyax Corp.
    Inventors: Jinan Yu, M. Daniel Potter, Marilous Potter, legal representative, Brian D. Kelley, Jeffrey S. Deetz, James E. Booth
  • Binding molecules for human factor VIII and factor VIII-like proteins
    Patent number: 7112438
    Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: September 26, 2006
    Assignee: Dyax Corp.
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James E. Booth
  • Methods for producing factor VIII proteins
    Publication number: 20040087776
    Abstract: Methods are provided for purification of Factor VIII polypeptides by immunoaffinity chromatography and ion exchange chromatography, in which the eluate from the immunoaffinity column is diluted with a solution comprising higher salt concentration, or lower non-polar agent concentration than that of the elution solution, prior to passing the diluted solution through the ion exchange column. The methods result in improved purification without significant yield loss.
    Type: Application
    Filed: December 3, 2003
    Publication date: May 6, 2004
    Applicant: Genetics Institute, LLC
    Inventors: Brian D. Kelley, Suresh Vunnum, Johanna Dalborg, Anna Petersson
  • Methods for producing factor VIII proteins
    Patent number: 6683159
    Abstract: Methods are provided for purification of Factor VIII polypeptides by immunoaffinity chromatography and ion exchange chromatography, in which the eluate from the immunoaffinity column is diluted with a solution comprising higher salt concentration, or lower non-polar agent concentration than that of the elution solution, prior to passing the diluted solution through the ion exchange column. The methods result in improved purification without significant yield loss.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: January 27, 2004
    Assignee: Genetics Institute, LLC
    Inventors: Brian D. Kelley, Suresh Vunnum, Johanna Dalborg, Anna Petersson
  • Binding molecules for human factor VIII and factor VIII-like proteins
    Publication number: 20030165822
    Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
    Type: Application
    Filed: October 15, 2002
    Publication date: September 4, 2003
    Applicant: Dyax Corp.
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James E. Booth
  • Binding molecules for human factor VIII and factor VIII-like proteins
    Patent number: 6492105
    Abstract: Methods for detecting human factor VIII or factor VIII-like polypeptides in and isolating it from solutions such as blood or conditioned media are disclosed, together with reagents suitable for the purpose comprising binding moieties that recognize human factor VIII and/or a factor VIII-like polypeptide and form a binding complex therewith. Preferred polypeptide binding moieties are particularly disclosed.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: December 10, 2002
    Assignee: Dyax Corp.
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James Edward Booth
  • Methods for producing factor VIII proteins
    Publication number: 20020115832
    Abstract: Methods are provided for purification of Factor VIII polypeptides by immunoaffinity chromatography and ion exchange chromatography, in which the eluate from the immunoaffinity column is diluted with a solution comprising higher salt concentration, or lower non-polar agent concentration than that of the elution solution, prior to passing the diluted solution through the ion exchange column. The methods result in improved purification without significant yield loss.
    Type: Application
    Filed: December 29, 2000
    Publication date: August 22, 2002
    Inventors: Brian D. Kelley, Suresh Vunnum, Johanna Dalborg, Anna Petersson
  • Binding molecules for human factor VIII and factor VIII-like proteins
    Publication number: 20010014456
    Abstract: Methods for detecting human factor VIII or factor VIII-like polypeptides in and isolating it from solutions such as blood or conditioned media are disclosed, together with reagents suitable for the purpose comprising binding moieties that recognize human factor VIII and/or a factor VIII-like polypeptide and form a binding complex therewith. Preferred polypeptide binding moieties are particularly disclosed.
    Type: Application
    Filed: January 8, 2001
    Publication date: August 16, 2001
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James Edward Booth
  • Polypeptides for binding human factor VIII and fragments of human factor VIII
    Patent number: 6197526
    Abstract: Methods for detecting human factor VIII or factor VIII-like polypeptides in and isolating it from solutions such as blood or conditioned media are disclosed, together with reagents suitable for the purpose comprising binding moieties that recognize human factor VIII and/or a factor VIII-like polypeptide and form a binding complex therewith. Preferred polypeptide binding moieties are particularly disclosed.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: March 6, 2001
    Assignees: Dyax Corp., Genetics Inst.
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James Edward Booth
  • Formulations for delivery of osteogenic proteins
    Patent number: 5520923
    Abstract: A formulation is disclosed comprising a pharmaceutically acceptable admixture of an osteogenic protein and a sponge of porous particulate polymer matrix. The sponge may be prepared by treating the porous particulate polymer matrix with a suitable fusing material such as ethanol and a surfactant such as a polysorbate.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: May 28, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: Jane S. Tjia, Brian D. Kelley, Richard P. Northey, C. Michael Philbrook