Abstract: Initializing a software-defined server having software-defined NUMA domains includes, when booting a virtual environment defined by a set of hyper-kernels running on a plurality of physically interconnected computing nodes, accessing information associated with a software-defined NUMA domain configuration. It further includes, based at least in part on the accessed information, assigning software-defined NUMA domains to computing nodes. It further includes assigning virtualized resources to the software-defined NUMA domains. Handling a stalling event involving software-defined NUMA domains includes receiving an indication that a core or hyperthread which instantiates a virtual processor cannot access a virtualized resource needed by the core or hyperthread.