Patents by Inventor Brian D. Strahl

Brian D. Strahl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040186274
    Abstract: The present invention relates to the generation of antibodies that bind to specific modifications of the amino terminus of histone H3 and H2A peptides. More particularly, the present invention is directed to the generation of a set of antibodies that recognize various post-tanslational modifications of a histone modification cassette SGRGK (SEQ ID NO: 1), wherein the modifications are selected from the group consisting of a phosphorylated serine, methylated arginine and acetylated lysine. Compositions comprising these antibodies are used as diagnosed and screening tools.
    Type: Application
    Filed: January 2, 2004
    Publication date: September 23, 2004
    Inventors: C. David Allis, Scott D. Briggs, Brian D. Strahl
  • Publication number: 20040053848
    Abstract: The present invention related to the generation of methyllysine-specific histone antibodies. In particular, the H3 lysine 4 methylation specific antibody (Methyl(K4)H3) binds to histone H3 methylated at lysine 4. Methylation of lysine 4 (K4) on histone H3 has been associated with transcriptionally active regions of chromatin. A second antibody, H3 lysine 9 methylation specific antibody (Methyl(K9)H3) specifically binds to histone H3 methylated at lysine 9. Methylation of lysine 9 (K9) on histone H3 has been associated with gene silencing. These antibodies are useful in identifying regions of heterochromatin and euchromatin and serving as diagnostic and screening tools.
    Type: Application
    Filed: February 14, 2003
    Publication date: March 18, 2004
    Inventors: C. David Allis, Brian D. Strahl