Abstract: Medical devices for accessing the central nervous system, as well as making and using medical devices, are disclosed. An example medical device may include an expandable access port. The expandable access port may include a housing having a plurality of tines coupled thereto. A thrust washer may be disposed along the housing. An actuation member may be coupled to the housing. The actuation member may be designed to shift the plurality of tines between a first configuration and an expanded configuration.

Abstract: Medical devices for accessing the central nervous system, as well as making and using medical devices, are disclosed. An example medical device may include an expandable access sheath having a proximal end region and a distal end region. The expandable access sheath may be designed to shift between a first configuration and an expanded configuration. The expandable access sheath may include a tubular body having one or more axial support members disposed along the tubular body. The medical device may include an expansion member designed to shift the expandable access sheath between the first configuration and the expanded configuration.

Abstract: Medical devices for accessing the central nervous system, as well as making and using medical devices, are disclosed. An example medical device may include an expandable access sheath having a proximal end region and a distal end region. The expandable access sheath may be designed to shift between a first configuration and an expanded configuration. The expandable access sheath may include a tubular body having one or more axial support members disposed along the tubular body. The medical device may include an expansion member designed to shift the expandable access sheath between the first configuration and the expanded configuration.

Abstract: Medical devices for accessing the central nervous system, as well as making and using medical devices, are disclosed. An example medical device may include an expandable access port. The expandable access port may include a housing having a plurality of tines coupled thereto. A thrust washer may be disposed along the housing. An actuation member may be coupled to the housing. The actuation member may be designed to shift the plurality of tines between a first configuration and an expanded configuration.

Abstract: Medical devices for accessing the central nervous system, as well as making and using medical devices, are disclosed. An example medical device may include an expandable access sheath having a proximal end region and a distal end region. The expandable access sheath may be designed to shift between a first configuration and an expanded configuration. The expandable access sheath may include a tubular body having one or more axial support members disposed along the tubular body. The medical device may include an expansion member designed to shift the expandable access sheath between the first configuration and the expanded configuration.

Abstract: A one or two player ball game assembly comprising a motorized ball launcher that shoots balls upwards into the air in a random fountain like pattern. Each player catches or retrieves the launched balls and places them back into their designated reservoir. The reservoir gravity feeds the balls back into a striker mechanism. In one embodiment, the reservoirs are clear tubes so that each player may monitor the number of balls in each player's reservoir during play. The clear tubes also act as a fence, keeping each player on their respective sides thus minimizing possible collisions during play. In one embodiment, the game operates on an adjustable timer (e.g. 1-15 minutes) which automatically terminates powered to the motorized striker. The timer may also trigger an audible signal (e.g. bell) when the game is over. The winner is the player with the most balls in their reservoir at the end of play.

Abstract: An unmanned aerial vehicle (UAV) that can operate both as a conventional multicopter with no wing attached, or, it can operate as a winged multicopter. The detachable wing design used in the invention provides versatility without compromising performance; the wing attachment receptacles add no weight to the wingless multicopter configuration because they also function as the leg receptacles. In one embodiment, the base multicopter configuration is a quad-copter with four propeller drives. Four tubular receptacles, two forward and two aft, provide attachment points for the vertical struts of a detachable rectangular shaped wing, these vertical struts also function as the legs of the multicopter. The wing is fabricated using lightweight struts and rip stop nylon fabric which can be easily folded into a compact shape using quick release pins. In another embodiment, the wing is fabricated using a foam core.

Abstract: An unmanned aerial vehicle (UAV) that can operate both as a conventional multicopter with no wing attached, or, it can operate as a winged multicopter. The detachable wing design used in the invention provides versatility without compromising performance; the wing attachment receptacles add no weight to the wingless multicopter configuration because they also function as the leg receptacles. In one embodiment, the base multicopter configuration is a quad-copter with four propeller drives. Four tubular receptacles, two forward and two aft, provide attachment points for the vertical struts of a detachable rectangular shaped wing, these vertical struts also function as the legs of the multicopter. The wing is fabricated using lightweight struts and rip stop nylon fabric which can be easily folded into a compact shape using quick release pins. In another embodiment, the wing is fabricated using a foam core.

Abstract: An unmanned aerial vehicle (UAV) comprising a plurality of propeller drives rigidly mounted to a foldable frame with the motor rotors aligned in a vertical direction to provide a means of vertical takeoffs and landings. The foldable frame mounts a sheet sail at an angle with the horizontal that provides lift during the forward motion and tilt of the UAV. In one embodiment the shape of the sheet sail and frame are triangular with one or two propeller drives being mounted in close proximity to each of the three vertices. In another embodiment, the shape of the sheet sail and frame are triangular with one or two propeller drives being mounted in close proximity to each of the three vertices, and one or two propeller drives being mount in close proximity to the trailing edge of the spine, in between the trailing edge propeller drives. In some embodiments, the frame spars may be comprised of carbon fiber rods and the sheet sail may be comprised of ripstop nylon fabric.

Abstract: An unmanned aerial vehicle (UAV) comprising a plurality of propeller drives rigidly mounted to a foldable frame with the motor rotors aligned in a vertical direction to provide a means of vertical takeoffs and landings. The foldable frame mounts a sheet sail at an angle with the horizontal that provides lift during the forward motion and tilt of the UAV. In one embodiment the shape of the sheet sail and frame are triangular with one or two propeller drives being mounted in close proximity to each of the three vertices. In another embodiment, the shape of the sheet sail and frame are triangular with one or two propeller drives being mounted in close proximity to each of the three vertices, and one or two propeller drives being mount in close proximity to the trailing edge of the spine, in between the trailing edge propeller drives. In some embodiments, the frame spars may be comprised of carbon fiber rods and the sheet sail may be comprised of ripstop nylon fabric.

Abstract: This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution.

Abstract: This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution.

Abstract: This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution.