Abstract: Systems and methods of monitoring medication compliance are provided. A first node receives from a second node a picture of a pill bottle label and a picture of the number of pills in the pill bottle. The information on the label is predicted from the picture of the pill bottle. The medication and number of pills is predicted from the picture of the number of pills. Information associated with compliance to the dosage regimen of the medication is determined based on the predicted number of pills and the dosage regimen. The second node sends to the first node an indication of the information associated with the medication compliance.