Patents by Inventor Brian Daniel Doan

Brian Daniel Doan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PREPARING A SPIROINDOLINE AND A PRECURSOR THEREOF
    Publication number: 20110230660
    Abstract: The present invention relates to a method comprising the step of contacting a protected N,N-bis(2-X-ethyl)amine with a (2-fluorophenyl)acetonitrile in the presence of a water-soluble phase transfer reagent, concentrated aqueous base, and an immiscible organic solvent, and under such conditions to form a 4-(2-fluorophenyl)-4-piperidinecarbonitrile in at least a 70% yield, wherein X is a leaving group. The 4-(2-fluorophenyl)-4-piperidinecarbonitrile is useful in preparing spiroindolines, which can be used as precursors of compounds that are modulators of CCR2 receptor.
    Type: Application
    Filed: December 3, 2009
    Publication date: September 22, 2011
    Inventors: Stacie Calad, Brian Daniel Doan
  • Process for preparing protease inhibitor intermediates
    Patent number: 7145024
    Abstract: The present invention includes a method for preparing cyclic alcohols. The method includes a reduction, deprotection, and rearrangement scheme. The present invention further provides a method of preparation of an intermediate useful in the synthesis of compounds that function as inhibitors of the aspartyl protease enzyme of human immunodeficiency virus (HIV).
    Type: Grant
    Filed: September 16, 2002
    Date of Patent: December 5, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Brian Daniel Doan, Roman D Davis, Thomas Claiborne Lovelace
  • Process for preparing protease inhibitor intermediates
    Publication number: 20040204595
    Abstract: The present invention includes a method for preparing cyclic alcohols. The method includes a reduction, deprotection, and rearrangement scheme. The present invention further provides a method of preparation of an intermediate useful in the synthesis of compounds that function as inhibitors of the aspartyl protease enzyme of human immunodeficiency virus (HIV).
    Type: Application
    Filed: March 19, 2004
    Publication date: October 14, 2004
    Inventors: Brian Daniel Doan, Roman D Davis, Thomas Claiborne Lovelace