Abstract: A single system may provide to a patient: temperature change, remote ischemic conditioning, and sometimes both concurrently. The system may include a patient unit that includes an inflatable bladder, and a duct having a cavity. The patient unit is intended to be applied around a patient's limb. A temperature subsystem can force a flow of a first fluid through the cavity so that the first fluid can exchange heat with the patient's limb. The pressure subsystem may force a fluid into the bladder, to establish pressure against the limb. A controller may control both the temperature subsystem and the pressure subsystem, so as to control the treatment received by the patient.