Patents by Inventor Brian David Warner
Brian David Warner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10173220Abstract: Tissue dissociators configured to disrupt a biological tissue sample are provided. Aspects of the tissue dissociators may include a housing having a distal end and a proximal end, a cutting blade positioned at the distal end of the housing and a tissue actuator configured to be displaced along a longitudinal axis within the housing. Also provided are methods of using the tissue dissociators, as well as kits including the tissue dissociators.Type: GrantFiled: August 4, 2015Date of Patent: January 8, 2019Assignee: BECTON, DICKINSON AND COMPANYInventors: Aaron J. Middlebrook, Smita Ghanekar, Brian David Warner, Albert Mach, David Vrane
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Patent number: 10045913Abstract: Methods and devices for exchanging therapeutic agents, such as cells, from one liquid medium to another liquid medium are provided. Aspects of embodiments of the methods include transferring a therapeutic agent from a first medium, such as a freezing, storage or shipping buffer, into a second medium, such as a sterile physiologically compatible buffer. In certain aspects, the transfer of the therapeutic agent from a first medium to a second medium involves the use of acoustic-focusing, or acoustophoresis. Embodiments of the subject methods may facilitate the transfer of a therapeutic agent from a storage medium to an infusion medium, and in certain embodiments include administering the therapeutic agent contained in the infusion medium to the subject. Also provided by the present disclosure are devices for practicing the subject methods.Type: GrantFiled: November 1, 2016Date of Patent: August 14, 2018Assignee: Becton, Dickinson and CompanyInventors: Brian David Warner, John Dunne
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Patent number: 9835540Abstract: Devices for sorting components (e.g., cells) contained in a liquid sample are provided. In certain aspects, the devices include a magnetic separation device and an acoustic concentrator device fluidically coupled to magnetic separation device. Aspects of the invention further include methods for sorting cells in a liquid sample, and systems, and kits for practicing the subject methods.Type: GrantFiled: May 13, 2016Date of Patent: December 5, 2017Assignee: Becton, Dickinson and CompanyInventors: Liping Yu, Brian David Warner, Joseph T. Trotter
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Publication number: 20170042770Abstract: Methods and devices for exchanging therapeutic agents, such as cells, from one liquid medium to another liquid medium are provided. Aspects of embodiments of the methods include transferring a therapeutic agent from a first medium, such as a freezing, storage or shipping buffer, into a second medium, such as a sterile physiologically compatible buffer. In certain aspects, the transfer of the therapeutic agent from a first medium to a second medium involves the use of acoustic-focusing, or acoustophoresis. Embodiments of the subject methods may facilitate the transfer of a therapeutic agent from a storage medium to an infusion medium, and in certain embodiments include administering the therapeutic agent contained in the infusion medium to the subject. Also provided by the present disclosure are devices for practicing the subject methods.Type: ApplicationFiled: November 1, 2016Publication date: February 16, 2017Inventors: Brian David Warner, John Dunne
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Patent number: 9551643Abstract: Systems for sterile separation of magnetically labeled sample components and methods for using the same are provided. Embodiments of the systems include a magnetic separation device and a pliant sample container, where a portion of the pliant sample container is operatively coupled under pressure to the magnetic separation device. Also provided are methods of using the systems, as well as pliant sample containers configured for use with the subject systems and methods.Type: GrantFiled: November 26, 2012Date of Patent: January 24, 2017Assignee: Becton, Dickinson and CompanyInventors: Brian David Warner, Liping Yu
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Patent number: 9510998Abstract: Methods and devices for exchanging therapeutic agents, such as cells, from one liquid medium to another liquid medium are provided. Aspects of embodiments of the methods include transferring a therapeutic agent from a first medium, such as a freezing, storage or shipping buffer, into a second medium, such as a sterile physiologically compatible buffer. In certain aspects, the transfer of the therapeutic agent from a first medium to a second medium involves the use of acoustic-focusing, or acoustophoresis. Embodiments of the subject methods may facilitate the transfer of a therapeutic agent from a storage medium to an infusion medium, and in certain embodiments include administering the therapeutic agent contained in the infusion medium to the subject. Also provided by the present disclosure are devices for practicing the subject methods.Type: GrantFiled: June 30, 2015Date of Patent: December 6, 2016Assignee: Becton, Dickinson and CompanyInventors: Brian David Warner, John Dunne
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Patent number: 9513205Abstract: Devices for sorting components (e.g., cells) contained in a liquid sample are provided. In certain aspects, the devices include a magnetic separation device and an acoustic concentrator device fluidically coupled to magnetic separation device. Aspects of the invention further include methods for sorting cells in a liquid sample, and systems, and kits for practicing the subject methods.Type: GrantFiled: January 6, 2015Date of Patent: December 6, 2016Assignee: Becton, Dickinson and CompanyInventors: Liping Yu, Brian David Warner, Joseph T. Trotter
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Publication number: 20160252445Abstract: Devices for sorting components (e.g., cells) contained in a liquid sample are provided. In certain aspects, the devices include a magnetic separation device and an acoustic concentrator device fluidically coupled to magnetic separation device. Aspects of the invention further include methods for sorting cells in a liquid sample, and systems, and kits for practicing the subject methods.Type: ApplicationFiled: May 13, 2016Publication date: September 1, 2016Inventors: Liping Yu, Brian David Warner, Joseph T. Trotter
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Publication number: 20160175198Abstract: Methods and devices for exchanging therapeutic agents, such as cells, from one liquid medium to another liquid medium are provided. Aspects of embodiments of the methods include transferring a therapeutic agent from a first medium, such as a freezing, storage or shipping buffer, into a second medium, such as a sterile physiologically compatible buffer. In certain aspects, the transfer of the therapeutic agent from a first medium to a second medium involves the use of acoustic-focusing, or acoustophoresis. Embodiments of the subject methods may facilitate the transfer of a therapeutic agent from a storage medium to an infusion medium, and in certain embodiments include administering the therapeutic agent contained in the infusion medium to the subject. Also provided by the present disclosure are devices for practicing the subject methods.Type: ApplicationFiled: June 30, 2015Publication date: June 23, 2016Inventors: Brian David Warner, John Dunne
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Publication number: 20160069781Abstract: Tissue dissociators configured to disrupt a biological tissue sample are provided. Aspects of the tissue dissociators may include a housing having a distal end and a proximal end, a cutting blade positioned at the distal end of the housing and a tissue actuator configured to be displaced along a longitudinal axis within the housing. Also provided are methods of using the tissue dissociators, as well as kits including the tissue dissociators.Type: ApplicationFiled: August 4, 2015Publication date: March 10, 2016Inventors: Aaron J. Middlebrook, Smita Ghanekar, Brian David Warner, Albert Mach, David Vrane
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Patent number: 9095494Abstract: Methods and devices for exchanging therapeutic agents, such as cells, from one liquid medium to another liquid medium are provided. Aspects of embodiments of the methods include transferring a therapeutic agent from a first medium, such as a freezing, storage or shipping buffer, into a second medium, such as a sterile physiologically compatible buffer. In certain aspects, the transfer of the therapeutic agent from a first medium to a second medium involves the use of acoustic-focusing, or acoustophoresis. Embodiments of the subject methods may facilitate the transfer of a therapeutic agent from a storage medium to an infusion medium, and in certain embodiments include administering the therapeutic agent contained in the infusion medium to the subject. Also provided by the present disclosure are devices for practicing the subject methods.Type: GrantFiled: September 28, 2012Date of Patent: August 4, 2015Assignee: Becton, Dickinson and CompanyInventors: Brian David Warner, John Dunne
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Publication number: 20150177111Abstract: Aspects of the present disclosure include methods for processing a biological sample. Methods according to certain embodiments include disrupting a biological sample to produce a disrupted biological sample and acoustically separating larger components from smaller components in the disrupted biological sample. In certain embodiments, methods may include monitoring aggregation while the biological sample is being processed. Methods, in certain instances, also include acoustically separating cells from cellular debris and non-cellular macromolecules as well as magnetically separating magnetically labelled moieties from unlabeled moieties. Systems, including a disrupter, one or more acoustic concentrator devices, feedback monitors and magnetic separation devices suitable for practicing the subject methods are also described.Type: ApplicationFiled: December 11, 2014Publication date: June 25, 2015Inventors: Brian David Warner, Liping Yu, Smita Ghanekar, Jianying Cao
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Publication number: 20150160116Abstract: Devices for sorting components (e.g., cells) contained in a liquid sample are provided. In certain aspects, the devices include a magnetic separation device and an acoustic concentrator device fluidically coupled to magnetic separation device. Aspects of the invention further include methods for sorting cells in a liquid sample, and systems, and kits for practicing the subject methods.Type: ApplicationFiled: January 6, 2015Publication date: June 11, 2015Inventors: Liping Yu, Brian David Warner, Joseph T. Trotter
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Patent number: 8956536Abstract: Devices for sorting components (e.g., cells) contained in a liquid sample are provided. In certain aspects, the devices include a magnetic separation device and an acoustic concentrator device fluidically coupled to magnetic separation device. Aspects of the invention further include methods for sorting cells in a liquid sample, and systems, and kits for practicing the subject methods.Type: GrantFiled: October 23, 2013Date of Patent: February 17, 2015Assignee: Becton, Dickinson and CompanyInventors: Liping Yu, Brian David Warner, Joseph T. Trotter
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Publication number: 20150010939Abstract: Systems for sterile separation of magnetically labeled sample components and methods for using the same are provided. Embodiments of the systems include a magnetic separation device and a pliant sample container, where a portion of the pliant sample container is operatively coupled under pressure to the magnetic separation device. Also provided are methods of using the systems, as well as pliant sample containers configured for use with the subject systems and methods.Type: ApplicationFiled: November 26, 2012Publication date: January 8, 2015Applicant: BECTON, DICKINSON AND COMPANYInventors: Brian David Warner, Liping Yu
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Publication number: 20140193381Abstract: Methods and devices for exchanging therapeutic agents, such as cells, from one liquid medium to another liquid medium are provided. Aspects of embodiments of the methods include transferring a therapeutic agent from a first medium, such as a freezing, storage or shipping buffer, into a second medium, such as a sterile physiologically compatible buffer. In certain aspects, the transfer of the therapeutic agent from a first medium to a second medium involves the use of acoustic-focusing, or acoustophoresis. Embodiments of the subject methods may facilitate the transfer of a therapeutic agent from a storage medium to an infusion medium, and in certain embodiments include administering the therapeutic agent contained in the infusion medium to the subject. Also provided by the present disclosure are devices for practicing the subject methods.Type: ApplicationFiled: September 28, 2012Publication date: July 10, 2014Inventors: Brian David Warner, John Dunne
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Publication number: 20140120570Abstract: Devices for sorting components (e.g., cells) contained in a liquid sample are provided. In certain aspects, the devices include a magnetic separation device and an acoustic concentrator device fluidically coupled to magnetic separation device. Aspects of the invention further include methods for sorting cells in a liquid sample, and systems, and kits for practicing the subject methods.Type: ApplicationFiled: October 23, 2013Publication date: May 1, 2014Inventors: Liping Yu, Brian David Warner, Joseph T. Trotter
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Publication number: 20120065092Abstract: Methods of detecting a fusion analyte in a sample are provided. Aspects of the methods include preparing a reaction mixture that includes a sample and a microparticle comprising a capture ligand for the fusion analyte, as well as first and second fluorescently labeled detector molecules. One of the first and second detector molecules specifically binds to the fusion analyte and the other specifically binds to a parent molecule thereof. Also provided are systems and kits configured for use in practicing methods of the invention.Type: ApplicationFiled: August 15, 2011Publication date: March 15, 2012Inventors: Hobert WAI, Thomas Martin HENRIKSSON, Brian David WARNER
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Patent number: 8021839Abstract: Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a polynucleotide that may include nucleic acid analogs and that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/polynucleotide hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/polynucleotide hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.Type: GrantFiled: February 23, 2007Date of Patent: September 20, 2011Assignee: Investigen, Inc.Inventors: Charles Robert Bupp, II, K. Yeon Choi, Rachel Anne Holmes-Davis, Alexander Izmailov, Heather Koshinsky, Christopher Jon Nulf, Mickey Urdea, Miaomiao Wang, Brian David Warner, Michael Zwick
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Patent number: 7964355Abstract: The present invention relates to the methods for assaying an analyte comprising a nucleic acid analog binding substrate in a sample, comprising reacting a catalytic complex comprising a nucleic acid analog, a nucleic acid analog specific binding substrate and a light reactive dye with a light stimulus, and detecting the presence or absence or amount of a reaction product of the catalytic complex and light stimulus. The present invention also relates to a method of assaying a nucleic acid analyte in a sample using an analyte-specific reporter complex. The present invention also relates to a method of assaying an analyte in a sample using a reporter molecule.Type: GrantFiled: February 17, 2009Date of Patent: June 21, 2011Assignee: Investigen, Inc.Inventors: Maiomiao Wang, Rachel Anne Holmes-Davis, Rick Blidner, Zbigniew Rafinski, Beata Anna Jedrzejewska, Jerzy Paczkowski, Brian David Warner, Heather Koshinsky