Abstract: Provided are proteins and peptides including the sequence -RXKF-, where X is a 2-thiohistidine residue or 2-thiohistidine residue analogue and each residue of the sequence has D or L stereochemistry. Also provided are compositions and methods of using these proteins and peptides. The protein and peptides may be used to treat individuals having diseases associated with mitochondrial dysfunction and/or diseases associated with HOCl-mediated injury and/or chlorine gas exposure.

Abstract: A system and method for automatically analyzing virtual machine bytecode of a software application and adding additional bytecode operable to determine information regarding network communication performed by the software application are described. According to one embodiment of the method, program code of a software application may be received, wherein the program code includes bytecode for a virtual machine. The bytecode may be automatically analyzed to detect network communication functionality. The method may operate to automatically add additional bytecode to the bytecode of the software application, where the added bytecode is operable to determine information regarding the network communication.

Abstract: A system and method for automatically modifying a native code module accessed in a user software application are described herein. The user software application may include virtual machine bytecode. Access to the native code module may be detected during execution of the virtual machine bytecode. The native code module may be automatically modified by adding instrumentation code to determine various types of information regarding execution of the native code module, and the access may be directed to the modified native code module.

Abstract: A system and method for automatically analyzing virtual machine bytecode of a software application and adding additional bytecode operable to determine information regarding database access performed by the software application are described. According to one embodiment of the method, program code of a software application may be received, wherein the program code includes bytecode for a virtual machine. The bytecode may be automatically analyzed to detect access to a database. The method may operate to automatically add additional bytecode to the bytecode of the software application, where the added bytecode is operable to determine information regarding the access to the database.

Abstract: A SAS expander or initiator places PHYs in a wide port into a persistent reduced power state by signaling to the connected SAS device that the SAS expander or initiator intends to route data traffic through other PHYs in the wide port. The SAS expander or initiator and connected SAS device agree to disuse certain PHYs so that the PHYs enter a reduced power state according to SAS standards.

Abstract: A system and method for automatically analyzing virtual machine bytecode of a software application and adding additional bytecode operable to determine information regarding network communication performed by the software application are described. According to one embodiment of the method, program code of a software application may be received, wherein the program code includes bytecode for a virtual machine. The bytecode may be automatically analyzed to detect network communication functionality. The method may operate to automatically add additional bytecode to the bytecode of the software application, where the added bytecode is operable to determine information regarding the network communication.

Abstract: A system is disclosed that facilitates creation of a web-based user interface which obtains user profile information from a database, gathers information from one or more users regarding product characteristics, correlates the user responses, performs statistical analysis of the user responses and presents the statistical analysis in a user comprehendible manner. The system also stores statistical ratings in a database correlated to a particular product or service. Ratings are provided to a user from the database based on a particular product or service, and the database can be queried to retrieve one or more user profiles that have rated a product of interest to the current use.

Abstract: Apparatus and methods for enabling multiple, unidirectional, virtual connections between a first SAS device and multiple other SAS devices in a SAS domain. An enhanced first SAS device may be substantially simultaneously coupled to each of two other SAS devices through one or more appropriately enhanced SAS expanders to allow substantially simultaneous unidirectional virtual connections from the first SAS device to both of the second and third SAS devices. Each virtual connection is, in essence, a half-duplex connection such that the first device is transmitting information to a second SAS device substantially simultaneous with the first device receiving information from a third SAS device. The enhancements are provided in a manner to allow backward compatibility with current SAS specifications for connectivity among devices not suitably enhanced in accordance with features and aspects hereof (e.g., with legacy devices).

Abstract: A system and method for automatically modifying a native code module accessed in a user software application are described herein. The user software application may include virtual machine bytecode. Access to the native code module may be detected during execution of the virtual machine bytecode. The native code module may be automatically modified by adding instrumentation code to determine various types of information regarding execution of the native code module, and the access may be directed to the modified native code module.

Abstract: A system and method for automatically analyzing virtual machine bytecode of a software application and adding additional bytecode operable to determine information regarding network communication performed by the software application are described. According to one embodiment of the method, program code of a software application may be received, wherein the program code includes bytecode for a virtual machine. The bytecode may be automatically analyzed to detect network communication functionality. The method may operate to automatically add additional bytecode to the bytecode of the software application, where the added bytecode is operable to determine information regarding the network communication.

Abstract: A system and method for automatically analyzing virtual machine bytecode of a software application and adding additional bytecode operable to determine information regarding database access performed by the software application are described. According to one embodiment of the method, program code of a software application may be received, wherein the program code includes bytecode for a virtual machine. The bytecode may be automatically analyzed to detect access to a database. The method may operate to automatically add additional bytecode to the bytecode of the software application, where the added bytecode is operable to determine information regarding the access to the database.

Abstract: Apparatus and methods for enabling multiple, unidirectional, virtual connections between a first SAS device and multiple other SAS devices in a SAS domain. An enhanced first SAS device may be substantially simultaneously coupled to each of two other SAS devices through one or more appropriately enhanced SAS expanders to allow substantially simultaneous unidirectional virtual connections from the first SAS device to both of the second and third SAS devices. Each virtual connection is, in essence, a half-duplex connection such that the first device is transmitting information to a second SAS device substantially simultaneous with the first device receiving information from a third SAS device. The enhancements are provided in a manner to allow backward compatibility with current SAS specifications for connectivity among devices not suitably enhanced in accordance with features and aspects hereof (e.g., with legacy devices).

Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

Abstract: The present invention relates, in one embodiment, to a method of preventing or treating diabetes using low molecular weight antioxidants. In a further embodiment, the invention relates to a method of protecting and/or enhancing viability of cells/tissues/organs during isolation (harvesting), preservation, expansion and/or transplantation. In yet another embodiment, the present invention relates to a method of inducing immune tolerance. The invention also relates to compounds and compositions suitable for use in such methods.

Abstract: A method and mechanism for managing dynamically allocated memory. Portions of memory which are available for allocation have additional information stored in association with each portion which indicates whether the portion has been previously identified as being prematurely freed. In addition, a checksum is stored with each portion of memory. In response to a request for deallocation of a portion of memory, the portion of memory is not deallocated if it is identified as having been prematurely freed. Otherwise, the a checksum is calculated for the portion and it is freed. In response to an allocation request, a candidate portion of memory is identified for allocation and a checksum is calculated for the candidate portion. If the calculated checksum does not match a checksum previously stored for the candidate portion, the portion is identified as having been prematurely freed and is not returned for allocation.

Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

Abstract: Methods and apparatus for selectively allowing and disallowing changes to an impedance control signal applied to bus driver circuits coupling a device or system to a common, shared bus where impedance of the bus may vary over time. Well known impedance sensing circuits may be coupled to a common bus, such as a PCI bus, and may be used to generate an impedance control signal to be applied to well-known bus driver circuits, including, for example, PCI bus driver circuits, to vary the drive level of such bus driver circuits in accordance with the present electrical impedance sensed on the bus. Features and aspects hereof permit selectively allowing and disallowing changes to such impedance control signals as applied to the driver circuits based upon the present state of the bus and/or the present state of signals driven on the bus by the system embodying the features and aspects hereof.

Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

Abstract: The present invention relates, in general, to cancer therapy, and, in particular, to a method of preventing or treating cancer using low molecular weight antioxidants (e.g., mimetics of superoxide dismutase (SOD)) as the active agent or as a chemo- and/or radio-protectant. The invention also relates to compounds and compositions suitable for use in such a method.

Abstract: The present invention concerns methods and compositions for making and using Be complexes of defined compositions, which may have multiple functionalities and/or binding specificities. In various embodiment, Beryllium (Be) complexes may include Be such as 10Be and 7Be complexes. Such complexes find use in a wide variety of applications, particularly in the field of treatment, detection and/or diagnosis of infections, diseases and other health-related conditions, including but not limited to cancer, autoimmune disease, cardiovascular disease, metabolic diseases, degenerative diseases, and organ transplant rejection.