Abstract: Provided are Adenosine Deaminase (ADA), or a polypeptides or peptides having an ADA activity, or an ADA conjugate, pharmaceutical compositions and formulations, products of manufacture and kits, and methods containing them for the prevention and treatment of a scleroderma-associated vasculopathy, in particular proliferative obliterative vasculopathy, progressive obliterative vasculopathy or an idiopathic obliterative vasculopathy and/or preventing or decreasing the progression of scleroderma, wherein optionally the scleroderma comprises a local scleroderma or a diffuse, or a systemic scleroderma.

Abstract: Concepts and technologies are disclosed herein for providing and using a software defined network controller. A software defined network controller can be provided by a computing system that includes a processor. A service model that represents a service can be obtained. A network model that represents network resources that support the service can be obtained. Resources that support the service can be determined. Templates can be accessed to identify templates that relate to the resources. The templates identified can be assembled to obtain a template-based representation of the service. The template-based representation can be executed to determine if the service is ready for deployment.

Abstract: A propulsion control system provides different levels of jerk as a function of operator inputs and actual measured operational parameters in a machine. The system includes a power source, a continuously variable transmission (CVT) coupled to an output of the power source, a plurality of input/output devices, a plurality of sensors configured to generate signals indicative of operational parameters of the machine, and a controller communicatively coupled with the power source, the CVT, the input/output devices, and the sensors. The controller includes a database stored in a memory with a plurality of jerk values mapped to different operations of the machine selected from at least one of activation of a brake by an operator for an aggressive stop, a directional shift request from an operator to select one of forward, reverse, or neutral, and a set of operating conditions of the machine indicative of a blade load shedding mode.

Abstract: The present disclosure relates to systems and methods for machining knowledge reuse by determining a machining strategy for a designated part to be formed, based at least in part on machining strategy information used to form one or more similar parts. Methods include receiving an input representation (such as a 3D model) of the designated part, searching a machining knowledge database for one or more similar parts that have a shape similar to the designated part, retrieving machining strategy information that was used to form the similar parts, and deriving a machining strategy for the designated part based at least in part on the machining strategy information used to form the similar parts.

Abstract: A charge leveler coupled between an external power supply and a data storage device includes a current limiter to receive an input current from the external power supply and to provide a limited input current at no more than a pre-determined level. A charge reservoir couplable in parallel with an output of the current limiter supplements the limited input current when the pre-determined level is exceeded. The charge reservoir is replenished with surplus limited current when the data storage device draws less than the pre-determined level. A boost assist regulator monitors a requested current from the data storage device, and initiates operation of the charge reservoir to supplement the limited input current when the requested current exceeds the limited input current.

Abstract: Provided are Adenosine Deaminase (ADA), or a polypeptides or peptides having an ADA activity, or an ADA conjugate, pharmaceutical compositions and formulations, products of manufacture and kits, and methods containing them for the prevention and treatment of a scleroderma-associated vasculopathy, in particular proliferative obliterative vasculopathy, progressive obliterative vasculopathy or an idiopathic obliterative vasculopathy and/or preventing or decreasing the progression of scleroderma, wherein optionally the scleroderma comprises a local scleroderma or a diffuse, or a systemic scleroderma.

Abstract: A colored seal system, method, and apparatus. The colored seal system includes a barrel having a delivery end and an open end. The barrel includes multiple markings. The barrel markings include at least measurements and multiple fill indicators. The colored seal system includes a colored seal slidably positioned within the barrel for moving a delivery agent. The colored seal is visible within at least one of the fill indicators.

Abstract: Concepts and technologies are disclosed herein for providing and using a software defined network controller. A software defined network controller can be provided by a computing system that includes a processor. A service model that represents a service can be obtained. A network model that represents network resources that support the service can be obtained. Resources that support the service can be determined. Templates can be accessed to identify templates that relate to the resources. The templates identified can be assembled to obtain a template-based representation of the service. The template-based representation can be executed to determine if the service is ready for deployment.

Abstract: A method for configuring a data analyzer is provided. The method comprises displaying to a user, on a presentation interface coupled to a processor, a graphical representation of at least a portion of the data analyzer. A data analyzer configuration for the data analyzer is then generated using a user input interface, which is coupled to the presentation interface and the processor. The presentation interface then displays to the user a plurality of selectable machine train components. The method also comprises generating, using the user input interface, an interactive graphical representation of a machine train including at least one of the selectable machine train components. Using the processor, a configuration file is generated based on the data analyzer configuration and the graphical representation of the machine train. The configuration file facilitates diagnosing operation of the machine train using the data analyzer.

Abstract: One embodiment provides a system, method, and wireless endoscope for performing internal imaging. A first portion of a wireless endoscope including at least a lens and a light emitter for physical connection to a second portion of the wireless endoscope is received. The first portion is interchangeable. The first portion is inserted into a body while the second portion remains outside the body. The wireless endoscope is powered on in response to receiving user input from a user. A distal end proximate the lens is illuminated utilizing a light in communication with the light emitter. Video inside the body is captured utilizing a camera in communication with the lens. The video is wireless communicated to a receiver associated with a display.

Abstract: A propulsion control system provides different levels of jerk as a function of operator inputs and actual measured operational parameters in a machine. The system includes a power source, a continuously variable transmission (CVT) coupled to an output of the power source, a plurality of input/output devices, a plurality of sensors configured to generate signals indicative of operational parameters of the machine, and a controller communicatively coupled with the power source, the CVT, the input/output devices, and the sensors. The controller includes a database stored in a memory with a plurality of jerk values mapped to different operations of the machine selected from at least one of activation of a brake by an operator for an aggressive stop, a directional shift request from an operator to select one of forward, reverse, or neutral, and a set of operating conditions of the machine indicative of a blade load shedding mode.

Abstract: The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.

Abstract: A system, method, and apparatus for rating content. A determination of content being received by a user is made. A user interface for receiving a user selection of bias of the content and rating truthfulness of the content is presented to the user. The user selection is received through the user interface. A number of user selections of at least bias and truthfulness are automatically compiled. Results indicating the user selections are communicated.

Abstract: The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.

Abstract: Provided are Adenosine Deaminase (ADA), or a polypeptides or peptides having an ADA activity, or an ADA conjugate, pharmaceutical compositions and formulations, products of manufacture and kits, and methods containing them for the prevention and treatment of a scleroderma-associated vasculopathy, in particular proliferative obliterative vasculopathy, progressive obliterative vasculopathy or an idiopathic obliterative vasculopathy and/or preventing or decreasing the progression of scleroderma, wherein optionally the scleroderma comprises a local scleroderma or a diffuse, or a systemic scleroderma.

Abstract: The disclosure extends to devices, systems and methods for connecting one or more sensors to one or more printed circuit boards (PCB) in the distal end or tip of a scope. The disclosure also extends to a connector assembly for an image sensor for protecting the sensor and conveying information from the sensor to the PCB.

Abstract: An endoscopic peripheral includes a first end of a flexible cable including at least a camera and one or more lights enclosed by a tip at the first end. The tip is tapered for insertion of a portion of the first end into a body of a patient. The endoscopic peripheral includes one or more controls interconnected with and controlling the camera and the one or more lights. A second end of the flexible cable terminates in a plug configured to physically connect the endoscopic peripheral to an electronic device. The electronic device powers the camera and the one or more lights and displays content captured by the camera. The endoscopic peripheral is plug and play when connected to the electronic device. The diameter of the diameter of the endoscopic peripheral between the first end and the second end is approximately the same.

Abstract: Managing instant messages may include receiving instant messages created by or on behalf of one or more message sources for delivery to an intended recipient. From among the received instant messages, qualifying instant messages may be identified that satisfy a capture rule, and two or more of the qualifying instant messages may be captured. The intended recipient may be informed of the captured instant messages unobtrusively, and also may be enabled to manage the captured instant messages.