Abstract: A surgical instrument, has an end effector that includes an ultrasonic blade, and a clamp arm that moves relative to the ultrasonic blade from an opened position toward an intermediate position and a closed position. The clamp arm is offset from the ultrasonic blade to define a predetermined gap in the intermediate position between the opened position and the closed position. A clamp arm actuator connects to the clamp arm and moves from an opened configuration to a closed configuration to direct the clamp arm from the opened position toward the intermediate position and the closed position. A spacer connects with the clamp arm to inhibit movement of the clamp arm from the intermediate position toward the closed position for maintaining the predetermined gap between the clamp arm and the ultrasonic blade.

Abstract: An alignment apparatus for aligning components of an optical assembly include a chuck configured to support the optical assembly thereon, and an adjustable flexure assembly disposed around the chuck. The adjustable flexure assembly includes a plurality of flexures. The plurality of flexures are positioned relative to the chuck such that each of the plurality of flexures contact the optical assembly when the optical assembly is positioned on the chuck.

Abstract: Oral care compositions and/or unit-dose oral care compositions comprising a high level of surfactant. Oral care compositions and/or unit-dose oral care compositions with a high foaming efficiency. Oral care compositions and/or unit-dose oral care compositions with one or more web forming materials, one or more surfactants, and a sugar alcohol.

Abstract: A detergent product containing one or more active agents is provided.

Abstract: A scent dispenser may comprise a vial retaining mechanism, a heating element, vial sensor, and a controller. The vial retaining mechanism includes a vial coupling that removeably retains a vial containing a scented solution. The includes a wick extending from a cavity of the vial through an opening of a neck of the vial. The heating element is shaped to receive and heat the wick of the vial. The vial sensor includes an array of sensor pads that are arranged in alignment with the vial retained by the vial coupling. The controller is electrically coupled to the heating element and electrically coupled to the array of sensor pads. The controller regulates a temperature level of the heating element, and receives signals from the array of sensor pads and processing the signals to determine a fluid level of the vial.

Abstract: A scent dispenser may comprise a vial retaining mechanism, a heating element, vial sensor, and a controller. The vial retaining mechanism includes a vial coupling that removeably retains a vial containing a scented solution. The includes a wick extending from a cavity of the vial through an opening of a neck of the vial. The heating element is shaped to receive and heat the wick of the vial. The vial sensor includes an array of sensor pads that are arranged in alignment with the vial retained by the vial coupling. The controller is electrically coupled to the heating element and electrically coupled to the array of sensor pads. The controller regulates a temperature level of the heating element, and receives signals from the array of sensor pads and processing the signals to determine a fluid level of the vial.

Abstract: A cleaning device for cleaning a dispensing nozzle assembly of a beverage dispenser is disclosed. The dispensing nozzle assembly may include a macro-ingredient/diluent outlet and a number of micro-ingredient outlets surrounding the macro-ingredient/diluent outlet. The cleaning device may include a handle, a head end rotatably attached to the handle, a guidance protrusion extending from the head end, a first set of bristles extending from the head end and surrounding the guidance protrusion, and a second set of bristles extending from the head end adjacent to the first set of bristles.

Abstract: A unit-dose dentifrice composition includes a soluble fibrous composition and a nonfibrous composition. The soluble fibrous composition includes web forming material and tin ion source. The nonfibrous composition includes abrasive. The abrasive and the tin ion source are in separate locations within the unit-dose dentifrice composition.

Abstract: Disclosed herein are systems for more efficient production of aluminum chlorohydrates, where the systems comprise a support element and/or metal catalyst, where the support element is configured to support the metal reagent in the system. Methods for efficient production of aluminum chlorohydrates are also disclosed.

Abstract: A wearable computing device includes an outer covering defining an outer-most top surface and an outer perimeter and an internal volume defined, at least in part, by an inner surface of the outer covering. The wearable computing device also includes an electronic display and an electronic display module connector arranged within the internal volume. Further, the wearable computing device includes at least one biometric sensor electrode positioned on the outer-most top surface of the outer covering and wrapping around one or more side edges of the outer covering to the internal volume. Moreover, the wearable computing device includes a printed circuit board arranged within the internal volume. In addition, the wearable computing device includes a conductive component electrically connecting the biometric sensor electrode(s) to the printed circuit board through the electronic display module connector.

Abstract: A method of producing aluminum chlorohydrate comprises adding small form aluminum metal pellets to a reactant receiving space of a reactor tank to form a pellet bed; adding aqueous hydrochloric acid to the reactant receiving space of the reactor tank; and continuously circulating the aqueous hydrochloric acid through the pellet bed. In some embodiments, the continuously circulating aqueous hydrochloric acid dispels reaction gases from the pellet bed. Methods described herein can, in some cases, further comprise consecutively adding additional small form aluminum metal pellets to the reactant receiving space of the reactor tank as the small form aluminum metal pellets are consumed in the pellet bed.

Abstract: Herein is provided a recombinant tumor-selective viral particle comprising a nucleic acid encoding a recombinant polypeptide for directing an extracellular vesicle (EV) to at least one target cell, said recombinant polypeptide comprising: at least one targeting moiety for directing said EV to said at least one target molecule expressed by said at least one target cell; at least one EV-anchoring polypeptide; and at least one intravesicular polypeptide. The viral particle may be from an oncolytic viruses. Recombinant polypeptides for programming EVs to target particular molecules are also provided. Also described are therapeutic EVs for delivering payload polypeptides (and/or cargo molecules) to target cells, e.g., in vaccine or cell-free “CAR-T”-like applications, along with EVs for recruiting immune cells to target cells in EV-mediated BiTE -like applications. Oncolytic viruses may also be engineered to infect tumor cells and shed programmed EVs, yielding additional therapeutic effects.

Abstract: A design optimization method and system comprises preparing a symbolic tree, updating node symbol parameters using a plurality of samples, sampling the plurality of samples with a method for solving, the multi-armed bandit problem, promoting each sample in the plurality of samples down a path of the symbolic tree, evaluating each path with a fitness function, and outputting a path of the symbolic tree.

Abstract: Low-profile latching mechanisms and related mechanical interfaces for allowing straps and other fastening accessories for limb-wearable devices are provided. The mechanisms in question allow for a very strong, yet easily releasable, connection to be made between a strap accessory and a device housing, with very little of the mechanism being visible.