Patents by Inventor Brian Desmond Palmer

Brian Desmond Palmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10888567
    Abstract: Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: January 12, 2021
    Assignee: Auckland UniServices Limited
    Inventors: Brian Desmond Palmer, Lai Ming Ching, Swarnalatha Akuratiya Gamage
  • Publication number: 20200039955
    Abstract: The present invention relates to compounds of formula (I) including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of tuberculosis.
    Type: Application
    Filed: October 14, 2019
    Publication date: February 6, 2020
    Inventors: Anna Marie Upton, Christopher Blair Cooper, Koenraad Jozef Lodewijk Marcel Andries, Jerome Emile Georges Guillemont, Walter Marcel Mathilde Van den Broeck, Brian Desmond Palmer, Zhenkun Ma
  • Patent number: 10508097
    Abstract: The present invention relates to compounds of formula (I) including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of tuberculosis.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: December 17, 2019
    Assignees: The Global Alliance for TB Drug Development, Inc., Janssen Pharmaceutica NV
    Inventors: Anna Marie Upton, Christopher Blair Cooper, Koenraad Jozef Lodewijk Marcel Andries, Jerome Emile Georges Guillemont, Walter Marcel Mathilde Van den Broeck, Brian Desmond Palmer, Zhenkun Ma
  • Publication number: 20190071417
    Abstract: The present invention relates to compounds of formula (I) including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of tuberculosis.
    Type: Application
    Filed: March 7, 2017
    Publication date: March 7, 2019
    Inventors: Anna Marie Upton, Christopher Blair Cooper, Koenraad Jozef Lodewijk Marcel, Jerome Emile Georges Guillemont, Walter Marcel Mathilde Van den Broeck, Brian Desmond Palmer, Zhenkun Ma
  • Publication number: 20180244692
    Abstract: Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
    Type: Application
    Filed: August 25, 2016
    Publication date: August 30, 2018
    Inventors: Brian Desmond Palmer, Lai-Ming Ching
  • Publication number: 20170224701
    Abstract: Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
    Type: Application
    Filed: August 12, 2015
    Publication date: August 10, 2017
    Inventors: Brian Desmond Palmer, Lai Ming Ching, Swarnalatha Akuratiya Gamage
  • Patent number: 9198913
    Abstract: The present invention relates to novel nitroimidazooxazines, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: December 1, 2015
    Assignee: Global Alliance for TB Drug Development
    Inventors: William Alexander Denny, Andrew Mark Thompson, Adrian Blaser, Zhenkun Ma, Brian Desmond Palmer, Hamish Scott Sutherland, Iveta Kmentova
  • Publication number: 20120028973
    Abstract: The present invention relates to novel nitroimidazooxazines, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.
    Type: Application
    Filed: July 30, 2010
    Publication date: February 2, 2012
    Applicant: Global Alliance for TB Drug Development
    Inventors: William Alexander Denny, Andrew Mark Thompson, Adrian Blaser, Brian Desmond Palmer, Zhenkun Ma, Hamish Scott Sutherland, Iveta Kmentova
  • Patent number: 7666864
    Abstract: The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: February 23, 2010
    Assignee: Global Alliance for TB Drug Development
    Inventors: Charles Z. Ding, Genliang Lu, Keith Combrink, Dianjun D. Chen, Minsoo Song, Jiancheng Wang, Zhenkun Ma, Brian Desmond Palmer, Adrian Blaser, Andrew M. Thompson, Iveta Kmentova, Hamish Scott Sutherland, William Alexander Denny
  • Publication number: 20090281088
    Abstract: The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.
    Type: Application
    Filed: March 25, 2009
    Publication date: November 12, 2009
    Applicant: Global Alliance for TB Drug Development
    Inventors: Charles Z. Ding, Genliang Lu, Keith Combrink, Dianjun D. Chen, Minsoo Song, Jiancheng Wang, Zhenkun Ma, Brian Desmond Palmer, Adrian Blaser, Andrew M. Thompson, Iveta Kmentova, Hamish Scott Sutherland, William Alexander Denny
  • Publication number: 20090275577
    Abstract: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.
    Type: Application
    Filed: June 15, 2009
    Publication date: November 5, 2009
    Inventors: Richard John Sciotti, Jeremy Tyson Starr, Christopher Richardson, Gordon William Rewcastle, Huifen Chen, Brian Desmond Palmer, Hamish Scott Sutherland, Julie Ann Spicer
  • Patent number: 7563788
    Abstract: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: July 21, 2009
    Assignee: Pfizer Inc.
    Inventors: Richard John Sciotti, Jeremy Tyson Starr, Christopher Richardson, Gordon William Rewcastle, Huifen Chen, Brian Desmond Palmer, Hamish Scott Sutherland, Julie Ann Spicer
  • Publication number: 20070191394
    Abstract: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.
    Type: Application
    Filed: March 7, 2005
    Publication date: August 16, 2007
    Inventors: Richard John Sciotti, Jeremy Tyson Starr, Christopher Richardson, Gordon William Rewcastle, Huifen Chen, Brian Desmond Palmer, Hamish Scott Sutherland, Julie Ann Spicer
  • Patent number: 7094798
    Abstract: This invention relates to pyrrolocarbazole derivatives according formula I wherein R1, R2, R7, R8, R9, X and Y are as defined in the specification wherein said derivatives specifically inhibit one or both of the checkpoint kinases Wee1 and Chk1
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: August 22, 2006
    Assignee: Pfizer Inc
    Inventors: Richard John Booth, Ellen Myra Dobrusin, Alan Kraker, Lorna Helen Mitchell, William Alexander Denny, Jeffrey Bruce Smaill, Andrew Mark Thompson, Florence Oliver Joseph McCarthy, Ho Huat Lee, Brian Desmond Palmer
  • Patent number: 6517836
    Abstract: A range of aziridin-1-yl nitrobenzamides are provided for use as prodrugs in conjunction with nitroreductase (NR) enzymes. The amides may have 1 or 2-substituents which may be bulky and polar. For example, 5-(aziridin-1-yl)-N-[2-(4-morpholino)ethyl]-2,4-dinitrobenzamide of Formula (A) was found to be highly active against all NR+ cell lines tested.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: February 11, 2003
    Assignee: Auckland Uniservices Limited
    Inventors: William Alexander Denny, Graham John Atwell, Brian Desmond Palmer, William Robert Wilson
  • Patent number: 6218388
    Abstract: Benzimidazoles of Formula I below are inhibitors of protein tyrosine kinases, and are useful in treating cellular proliferation. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: April 17, 2001
    Assignee: Warner-Lambert Company
    Inventors: Diane Harris Boschelli, William Alexander Denny, Annette Marian Doherty, James Marino Hamby, Sonya Shah Khatana, James Bernard Kramer, Brian Desmond Palmer, Howard Daniel Hollis Showalter
  • Patent number: 5990146
    Abstract: Benzimidazoles of Formula I below are inhibitors of protein tyrosine kinases, and are useful in treating cellular proliferation. ##STR1## The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.
    Type: Grant
    Filed: August 17, 1998
    Date of Patent: November 23, 1999
    Assignee: Warner-Lambert Company
    Inventors: Diane Harris Boschelli, William Alexander Denny, Annette Marian Doherty, James Marino Hamby, Sonya Shah Khatana, James Bernard Kramer, Brian Desmond Palmer, Howard Daniel Hollis Showalter
  • Patent number: 5750782
    Abstract: The invention provides nitroaniline derivatives represented by general formula (1) where the nitro group is substituted at any one of the available benzene positions 2-6; where R and A separately represent the groups NO.sub.2, CN,COOR.sup.1, CONR.sup.1 R.sup.2, CSNR.sup.1 R.sup.2 or SO.sub.2 NR.sup.1 R.sup.2 and A is substituted at any one of the available benzene positions 2-6; where B represents N(CH.sub.2 CH.sub.2 halogen).sub.2 or N(CH.sub.2 CH.sub.2 OSO.sub.2 R.sup.3).sub.2 substituted at any one of the available benzene positions; and where R.sup.1, R.sup.2 and R.sup.3 separately represent H, or lower alkyl optionally substituted with hydroxyl, ether, carboxy or amino functions, including cyclic structures, or R.sup.1 and R.sup.2 together with the nitrogen form a heterocyclic structure, and pharmaceutical preparations containing them. These compounds have activity as hypoxia-selective cytotoxins, reductively-activated prodrugs for cytotoxins, hypoxic cell radiosensitisers, and anticancer agents.
    Type: Grant
    Filed: July 23, 1996
    Date of Patent: May 12, 1998
    Assignee: Cancer Research Campaign Technology Limited
    Inventors: William Alexander Denny, Brian Desmond Palmer, William Robert Wilson