Abstract: Disclosed herein are compounds and methods for inhibiting Aha1 for the treatment of tauopathies and neurodegenerative diseases. The Aha1 inhibitor may reduce the interaction between Aha1 and Hsp90. The Aha1 inhibitor may reduce aggregation of tau protein. The Aha1 inhibitor may include a compound selected from KU-177, KU-174, and KU-308.

Abstract: In an integrated turbogenerator system having an air intake for a compressor to supply combustion air to a combustor, an electric brake device such as a resistor is connected to the electrical power output of the turbogenerator and is situated in the air intake to be cooled by the stream of combustion air flowing into the intake. When load transients require unloading excess electrical power produced by the turbogenerator, the brake resistor is supplied with at least part of the excess electrical power to create heat energy and thereby heat the in-flowing combustion air to lower the combustor efficiency, turbogenerator power produced, and excess electric power to be unloaded. An algorithm may be provided for controlling the turbogenerator speed deceleration rate to maintain the brake resistor at or near a physical temperature limit.

Abstract: In an integrated turbogenerator system having an air intake for a compressor to supply combustion air to a combustor, an electric brake device such as a resistor is connected to the electrical power output of the turbogenerator and is situated in the air intake to be cooled by the stream of combustion air flowing into the intake. When load transients require unloading excess electrical power produced by the turbogenerator, the brake resistor is supplied with at least part of the excess electrical power to create heat energy and thereby heat the in-flowing combustion air to lower the combustor efficiency, turbogenerator power produced, and excess electric power to be unloaded. An algorithm may be provided for controlling the turbogenerator speed deceleration rate to maintain the brake resistor at or near a physical temperature limit.

Abstract: A system and method for modular control of a multi-fuel turbogenerator include separate controllers for controlling fuel supplied to the combustor and power output from the generator. The power controller generates a fuel command based on the required turbine exhaust temperature, where the fuel command is independent of the particular fuel being used. Fuels may include natural gas, diesel, propane, waste gas, or gasoline, for example. The power controller communicates the fuel command and the airflow or calculated air/fuel ratio to the fuel controller which selects an appropriate mode of operation for the injectors. Injector operating modes include one or more pilot modes where fuel is not mixed with air prior to combustion, and one or more premix modes where fuel is highly mixed with air prior to combustion.

Abstract: A system and method for modular control of a multi-fuel turbogenerator include separate controllers for controlling fuel supplied to the combustor and power output from the generator. The power controller generates a fuel command based on the required turbine exhaust temperature, where the fuel command is independent of the particular fuel being used. Fuels may include natural gas, diesel, propane, waste gas, or gasoline, for example. The power controller communicates the fuel command and the airflow or calculated air/fuel ratio to the fuel controller which selects an appropriate mode of operation for the injectors. Injector operating modes include one or more pilot modes where fuel is not mixed with air prior to combustion, and one or more premix modes where fuel is highly mixed with air prior to combustion.

Abstract: A system and method for modular control of a multi-fuel turbogenerator include separate controllers for controlling fuel supplied to the combustor and power output from the generator. The power controller generates a fuel command based on the required turbine exhaust temperature, where the fuel command is independent of the particular fuel being used. Fuels may include natural gas, diesel, propane, waste gas, or gasoline, for example. The power controller communicates the fuel command and the airflow or calculated air/fuel ratio to the fuel controller which selects an appropriate mode of operation for the injectors. Injector operating modes include one or more pilot modes where fuel is not mixed with air prior to combustion, and one or more premix modes where fuel is highly mixed with air prior to combustion.

Abstract: A system and method resulting in a balanced minimization of detrimental hydrocarbon, CO and NOx emissions by regulating the air to fuel ratio in a combustor. The turbogenerator system includes a recuperator which separates air flow into a primary passage and a dilution passage. A combustor is connected to the recuperator. The cumbustor has a primary zone and a dilution zone. A controlled air valve is disposed in the air flow such that air to fuel ratio in the primary zone of the combustor is regulated at a predetermined level which minimizes the emissions.

Abstract: A system and method for modular control of a multi-fuel turbogenerator include separate controllers for controlling fuel supplied to the combustor and power output from the generator. The power controller generates a fuel command based on the required turbine exhaust temperature, where the fuel command is independent of the particular fuel being used. Fuels may include natural gas, diesel, propane, waste gas, or gasoline, for example. The power controller communicates the fuel command and the airflow or calculated air/fuel ratio to the fuel controller which selects an appropriate mode of operation for the injectors. Injector operating modes include one or more pilot modes where fuel is not mixed with air prior to combustion, and one or more premix modes where fuel is highly mixed with air prior to combustion.

Abstract: A turbogenerator/motor control system having a plurality of proportional integral control loops including a fuel command control loop and a current command control loop. The exhaust gas temperature of the gas turbine of the turbogenerator/motor is maintained at a constant value with stability is achieved by varying the sampling times of the different proportional integral controls within the control loops.