Patents by Inventor Brian Duff

Brian Duff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240424047
    Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.
    Type: Application
    Filed: September 6, 2024
    Publication date: December 26, 2024
    Inventors: Yun Kau Tam, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
  • Publication number: 20230381260
    Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.
    Type: Application
    Filed: August 10, 2023
    Publication date: November 30, 2023
    Inventors: Yun Kau TAM, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
  • Publication number: 20220000955
    Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.
    Type: Application
    Filed: September 20, 2021
    Publication date: January 6, 2022
    Inventors: Yun Kau TAM, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
  • Patent number: 11123389
    Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: September 21, 2021
    Assignee: MAIN HARBOUR BIOTECH INTERNATIONAL LIMITED
    Inventors: Yun Kau Tam, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
  • Publication number: 20190247454
    Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.
    Type: Application
    Filed: April 5, 2019
    Publication date: August 15, 2019
    Inventors: Yun Kau TAM, Yi-Chan James LIN, Brian Duff SLOLEY, Chih-Yuan TSENG
  • Patent number: 10320860
    Abstract: The disclosure includes a system and method for detecting fine grain copresence between users. The system includes a processor and a memory storing instructions that when executed cause the system to: transmit a wakeup signal to a plurality of devices based on coarse grain location information; send a request to a first device of the plurality of devices to transmit a token using a first communication technology to determine fine grain copresence; receive a first token acknowledgment from a first subset of the plurality of devices; send a request to a second device of the first subset of the plurality of devices to transmit the token using a second communication technology to determine fine grain copresence; receive a second token acknowledgment from a second subset of the plurality of devices; and refine copresence based on receiving the first and second token acknowledgment.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: June 11, 2019
    Assignee: Google LLC
    Inventors: Andrew Ames Bunner, Alan Lee Gardner, III, Mohammed Waleed Kadous, Brian Patrick Williams, Marc Stogaitis, Nadav Aharony, Brian Duff, Pascal Tom Getreuer, Zhentao Sun, Daniel Estrada Alva, Ami Patel, Benjamin Razon, Richard Daniel Webb, Tony Weber, Thomas Yuchin Chao, Ryan Michael Rifkin, Richard Francis Lyon, Liem Tran, Joseph A. Farfel
  • Patent number: 10307451
    Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: June 4, 2019
    Assignee: SINOVEDA CANADA INC.
    Inventors: Yun Kau Tam, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
  • Publication number: 20170266246
    Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.
    Type: Application
    Filed: May 9, 2016
    Publication date: September 21, 2017
    Inventors: Yun Kau Tam, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
  • Patent number: 9769624
    Abstract: The disclosure includes a system and method for detecting fine grain copresence between users. The system includes a processor and a memory storing instructions that when executed cause the system to receive user input regarding copresence detection settings for a first user device, the copresence detection settings comprising a location and/or a user access control list, and determine a current location of the first user device. The system may determine whether copresence detection of the first user device is enabled at the current location based on the copresence detection settings and the current location. Based on determining that copresence detection is enabled, the system may refine copresence and perform an action based on fine grain copresence of the first and second user device.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: September 19, 2017
    Assignee: Google Inc.
    Inventors: Nadav Aharony, Andrew Ames Bunner, Alan Lee Gardner, III, Mohammed Waleed Kadous, Brian Patrick Williams, Marc Stogaitis, Brian Duff, Pascal Tom Getreuer, Zhentao Sun, Daniel Estrada Alva, Ami Patel, Benjamin Razon, Richard Daniel Webb, Tony Weber, Thomas Yuchin Chao, Ralph Jacob Cressman, Denise Ho, Liem Tran, Joseph A. Farfel
  • Patent number: 9386417
    Abstract: The disclosure includes a system and method for detecting fine grain copresence between users. The system includes a processor and a memory storing instructions that when executed cause the system to: process one or more signals to determine coarse grain location information of a first device and a second device; determine whether the first device and the second device are copresent based on the coarse grain location information; in response to determining that the first device and the second device are copresent based on the coarse grain location information, transmit a signal to the second device to alert the second device to listen for a fine grain copresence token from the first device; and refine copresence based on receiving an indication that the second device has received the fine grain copresence token.
    Type: Grant
    Filed: May 24, 2015
    Date of Patent: July 5, 2016
    Assignee: Google Inc.
    Inventors: Andrew Ames Bunner, Alan Lee Gardner, III, Mohammed Waleed Kadous, Brian Patrick Williams, Marc Stogaitis, Nadav Aharony, Brian Duff, Pascal Tom Getreuer, Zhentao Sun, Daniel Estrada Alva, Ami Patel, Benjamin Razon, Richard Daniel Webb, Tony Weber, Thomas Yuchin Chao, Ryan Michael Rifkin, Richard Francis Lyon, Liem Tran, Joseph A. Farfel
  • Patent number: 9333192
    Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating bone remodeling, and prevention and treatment of osteoporosis.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: May 10, 2016
    Assignee: SINOVEDA CANADA, INC
    Inventors: Yun Kau Tam, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
  • Patent number: 9042912
    Abstract: The disclosure includes a system and method for detecting fine grain copresence between users. The system includes a processor and a memory storing instructions that when executed cause the system to: process one or more signals to determine coarse grain location information of a first device and a second device; determine whether the first device and the second device are copresent based on the coarse grain location information; in response to determining that the first device and the second device are copresent based on the coarse grain location information, transmit a signal to the second device to alert the second device to listen for a fine grain copresence token from the first device; and refine copresence based on receiving an indication that the second device has received the fine grain copresence token.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: May 26, 2015
    Assignee: Google Inc.
    Inventors: Andrew Ames Bunner, Alan Lee Gardner, III, Mohammed Waleed Kadous, Brian Patrick Williams, Marc Stogaitis, Nadav Aharony, Brian Duff, Pascal Tom Getreuer, Zhentao Sun, Daniel Estrada Alva, Ami Patel, Benjamin Razon, Richard Daniel Webb, Tony Weber, Thomas Yuchin Chao, Ryan Michael Rifkin, Richard Francis Lyon, Liem Tran, Joseph A. Farfel
  • Publication number: 20140296329
    Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating bone remodeling, and prevention and treatment of osteoporosis.
    Type: Application
    Filed: April 2, 2014
    Publication date: October 2, 2014
    Inventors: Yun Kau TAM, Yi-Chan James LIN, Brian Duff SLOLEY, Chih-Yuan TSENG
  • Publication number: 20140057005
    Abstract: A phytoestrogen blend was developed using a pharmaceutical platform technology to identify the time course of active components and effect time course of these components in the biophase after administration of a red clover extract. This phytoestrogen blend consists of biochanin A, daidzein, equol and genistein. The recommended daily dosage ranges from 5 to 200 mg of total isoflavone.
    Type: Application
    Filed: November 1, 2013
    Publication date: February 27, 2014
    Inventors: Yun Kau TAM, Yi-Chan James LIN, Brian Duff SLOLEY, Chih-Yuan TSENG
  • Patent number: 8288138
    Abstract: A process and system for the conversion of biomass, such as spent brewers grain, into ethanol and other commercial products, such as pelletized fuel, biogas, fertilizer, and livestock feed, is disclosed. The method may include biomass pretreatment, hydrolysis, fermentation, distillation, and dehydration phases.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: October 16, 2012
    Assignee: NEAtech, LLC
    Inventors: Scott Birkmire, Chris Lindeman, Brian Duff, Jesse Spooner, Mark Yancey
  • Publication number: 20120077874
    Abstract: A phytoestrogen blend was developed using a pharmaceutical platform technology to identify the time course of active components and effect time course of these components in the biophase after administration of a red clover extract. This phytoestrogen blend consists of biochanin A, daidzein, equol and genistein. The recommended daily dosage ranges from 5 to 200 mg of total isoflavone.
    Type: Application
    Filed: October 2, 2011
    Publication date: March 29, 2012
    Inventors: Yun Kau TAM, Yi-Chan James LIN, Brian Duff SLOLEY, Chih-Yuan TSENG
  • Publication number: 20110177179
    Abstract: Processes describing approaches to prepare herbal extracts containing absorbables and/or precursors of absorbables are described. The procedures are based on the physiological events in the gastrointestinal tract. Improvement of component absorption can also be achieved by designing an appropriate extraction condition.
    Type: Application
    Filed: January 18, 2011
    Publication date: July 21, 2011
    Applicant: SINOVEDA CANADA, INC.
    Inventors: Yun Kau TAM, Yi-Chan James LIN, Brian Duff SLOLEY
  • Publication number: 20100196979
    Abstract: A process and system for the conversion of biomass, such as spent brewers grain, into ethanol and other commercial products, such as pelletized fuel, biogas, fertilizer, and livestock feed, is disclosed. The method may include biomass pretreatment, hydrolysis, fermentation, distillation, and dehydration phases.
    Type: Application
    Filed: July 28, 2009
    Publication date: August 5, 2010
    Applicant: BBI INTERNATIONAL, INC.
    Inventors: Scott Birkmire, Chris Lindeman, Brian Duff, Jesse Spooner, Mark Yancey
  • Publication number: 20080288176
    Abstract: The present invention provides a method of using a physiologically-based pharmacokinetic model to select a prodrug molecule (NO—X) comprising a therapeutic agent X (e.g. nonsteroidal anti-inflammatory drug, (NSAID)) and an appropriate nitric oxide donor NO. The NSAID can be a non-selective or selective cyclooxygenase inhibitor or other biocompatible compound comprising a carboxyl group. The pharmacokinetic model uses in vitro and/or in silico data to estimate an optimal set of parameters that can predict whether a particular NO—X candidate is capable of producing desirable therapeutic effects, e.g. enhanced anti-inflammatory activity, reduced intestinal, cardiac and renal toxicity. Accordingly, the present invention can greatly enhance proper selection of an appropriate candidate for drug development, thereby minimizing development time and conserving costs.
    Type: Application
    Filed: October 13, 2006
    Publication date: November 20, 2008
    Inventors: Yun Kau Tam, Christopher Mark Diaper, Hugh A. Semple, Douglas Thacher Ridgway, Yi-Chan James Lin, Brian Duff Sloley
  • Publication number: 20040115801
    Abstract: In one aspect, the invention provides cell cultures and culture conditions that facilitate the establishment of an intestinal epithelial cell culture that has characteristics of the intestinal epithelium, such as: transepithelial electrical resistance, enzyme expression and microvilli morphology. Cell cultures of the invention may use fatty acids such as sodium butyrate and kinase modulators such as 2-{1-[3-(amidinothio)propyl]-1H-indol-3-yl}-3-(1-meethylindol-3-yl)-maleimide methanesulfonate.
    Type: Application
    Filed: August 25, 2003
    Publication date: June 17, 2004
    Applicant: KINETANA GROUP INC.
    Inventors: Yi-Chan James Lin, Yun Kau Tam, Hugh Alexander Semple, Brian Duff Sloley