Patents by Inventor Brian Duff
Brian Duff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240424047Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.Type: ApplicationFiled: September 6, 2024Publication date: December 26, 2024Inventors: Yun Kau Tam, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
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Publication number: 20230381260Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.Type: ApplicationFiled: August 10, 2023Publication date: November 30, 2023Inventors: Yun Kau TAM, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
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Publication number: 20220000955Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.Type: ApplicationFiled: September 20, 2021Publication date: January 6, 2022Inventors: Yun Kau TAM, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
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Patent number: 11123389Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.Type: GrantFiled: April 5, 2019Date of Patent: September 21, 2021Assignee: MAIN HARBOUR BIOTECH INTERNATIONAL LIMITEDInventors: Yun Kau Tam, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
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Publication number: 20190247454Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.Type: ApplicationFiled: April 5, 2019Publication date: August 15, 2019Inventors: Yun Kau TAM, Yi-Chan James LIN, Brian Duff SLOLEY, Chih-Yuan TSENG
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Patent number: 10320860Abstract: The disclosure includes a system and method for detecting fine grain copresence between users. The system includes a processor and a memory storing instructions that when executed cause the system to: transmit a wakeup signal to a plurality of devices based on coarse grain location information; send a request to a first device of the plurality of devices to transmit a token using a first communication technology to determine fine grain copresence; receive a first token acknowledgment from a first subset of the plurality of devices; send a request to a second device of the first subset of the plurality of devices to transmit the token using a second communication technology to determine fine grain copresence; receive a second token acknowledgment from a second subset of the plurality of devices; and refine copresence based on receiving the first and second token acknowledgment.Type: GrantFiled: June 24, 2015Date of Patent: June 11, 2019Assignee: Google LLCInventors: Andrew Ames Bunner, Alan Lee Gardner, III, Mohammed Waleed Kadous, Brian Patrick Williams, Marc Stogaitis, Nadav Aharony, Brian Duff, Pascal Tom Getreuer, Zhentao Sun, Daniel Estrada Alva, Ami Patel, Benjamin Razon, Richard Daniel Webb, Tony Weber, Thomas Yuchin Chao, Ryan Michael Rifkin, Richard Francis Lyon, Liem Tran, Joseph A. Farfel
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Patent number: 10307451Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.Type: GrantFiled: May 9, 2016Date of Patent: June 4, 2019Assignee: SINOVEDA CANADA INC.Inventors: Yun Kau Tam, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
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Publication number: 20170266246Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.Type: ApplicationFiled: May 9, 2016Publication date: September 21, 2017Inventors: Yun Kau Tam, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
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Patent number: 9769624Abstract: The disclosure includes a system and method for detecting fine grain copresence between users. The system includes a processor and a memory storing instructions that when executed cause the system to receive user input regarding copresence detection settings for a first user device, the copresence detection settings comprising a location and/or a user access control list, and determine a current location of the first user device. The system may determine whether copresence detection of the first user device is enabled at the current location based on the copresence detection settings and the current location. Based on determining that copresence detection is enabled, the system may refine copresence and perform an action based on fine grain copresence of the first and second user device.Type: GrantFiled: June 24, 2015Date of Patent: September 19, 2017Assignee: Google Inc.Inventors: Nadav Aharony, Andrew Ames Bunner, Alan Lee Gardner, III, Mohammed Waleed Kadous, Brian Patrick Williams, Marc Stogaitis, Brian Duff, Pascal Tom Getreuer, Zhentao Sun, Daniel Estrada Alva, Ami Patel, Benjamin Razon, Richard Daniel Webb, Tony Weber, Thomas Yuchin Chao, Ralph Jacob Cressman, Denise Ho, Liem Tran, Joseph A. Farfel
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Patent number: 9386417Abstract: The disclosure includes a system and method for detecting fine grain copresence between users. The system includes a processor and a memory storing instructions that when executed cause the system to: process one or more signals to determine coarse grain location information of a first device and a second device; determine whether the first device and the second device are copresent based on the coarse grain location information; in response to determining that the first device and the second device are copresent based on the coarse grain location information, transmit a signal to the second device to alert the second device to listen for a fine grain copresence token from the first device; and refine copresence based on receiving an indication that the second device has received the fine grain copresence token.Type: GrantFiled: May 24, 2015Date of Patent: July 5, 2016Assignee: Google Inc.Inventors: Andrew Ames Bunner, Alan Lee Gardner, III, Mohammed Waleed Kadous, Brian Patrick Williams, Marc Stogaitis, Nadav Aharony, Brian Duff, Pascal Tom Getreuer, Zhentao Sun, Daniel Estrada Alva, Ami Patel, Benjamin Razon, Richard Daniel Webb, Tony Weber, Thomas Yuchin Chao, Ryan Michael Rifkin, Richard Francis Lyon, Liem Tran, Joseph A. Farfel
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Patent number: 9333192Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating bone remodeling, and prevention and treatment of osteoporosis.Type: GrantFiled: April 2, 2014Date of Patent: May 10, 2016Assignee: SINOVEDA CANADA, INCInventors: Yun Kau Tam, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
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Patent number: 9042912Abstract: The disclosure includes a system and method for detecting fine grain copresence between users. The system includes a processor and a memory storing instructions that when executed cause the system to: process one or more signals to determine coarse grain location information of a first device and a second device; determine whether the first device and the second device are copresent based on the coarse grain location information; in response to determining that the first device and the second device are copresent based on the coarse grain location information, transmit a signal to the second device to alert the second device to listen for a fine grain copresence token from the first device; and refine copresence based on receiving an indication that the second device has received the fine grain copresence token.Type: GrantFiled: June 24, 2014Date of Patent: May 26, 2015Assignee: Google Inc.Inventors: Andrew Ames Bunner, Alan Lee Gardner, III, Mohammed Waleed Kadous, Brian Patrick Williams, Marc Stogaitis, Nadav Aharony, Brian Duff, Pascal Tom Getreuer, Zhentao Sun, Daniel Estrada Alva, Ami Patel, Benjamin Razon, Richard Daniel Webb, Tony Weber, Thomas Yuchin Chao, Ryan Michael Rifkin, Richard Francis Lyon, Liem Tran, Joseph A. Farfel
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Publication number: 20140296329Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating bone remodeling, and prevention and treatment of osteoporosis.Type: ApplicationFiled: April 2, 2014Publication date: October 2, 2014Inventors: Yun Kau TAM, Yi-Chan James LIN, Brian Duff SLOLEY, Chih-Yuan TSENG
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Publication number: 20140057005Abstract: A phytoestrogen blend was developed using a pharmaceutical platform technology to identify the time course of active components and effect time course of these components in the biophase after administration of a red clover extract. This phytoestrogen blend consists of biochanin A, daidzein, equol and genistein. The recommended daily dosage ranges from 5 to 200 mg of total isoflavone.Type: ApplicationFiled: November 1, 2013Publication date: February 27, 2014Inventors: Yun Kau TAM, Yi-Chan James LIN, Brian Duff SLOLEY, Chih-Yuan TSENG
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Patent number: 8288138Abstract: A process and system for the conversion of biomass, such as spent brewers grain, into ethanol and other commercial products, such as pelletized fuel, biogas, fertilizer, and livestock feed, is disclosed. The method may include biomass pretreatment, hydrolysis, fermentation, distillation, and dehydration phases.Type: GrantFiled: July 28, 2009Date of Patent: October 16, 2012Assignee: NEAtech, LLCInventors: Scott Birkmire, Chris Lindeman, Brian Duff, Jesse Spooner, Mark Yancey
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Publication number: 20120077874Abstract: A phytoestrogen blend was developed using a pharmaceutical platform technology to identify the time course of active components and effect time course of these components in the biophase after administration of a red clover extract. This phytoestrogen blend consists of biochanin A, daidzein, equol and genistein. The recommended daily dosage ranges from 5 to 200 mg of total isoflavone.Type: ApplicationFiled: October 2, 2011Publication date: March 29, 2012Inventors: Yun Kau TAM, Yi-Chan James LIN, Brian Duff SLOLEY, Chih-Yuan TSENG
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Publication number: 20110177179Abstract: Processes describing approaches to prepare herbal extracts containing absorbables and/or precursors of absorbables are described. The procedures are based on the physiological events in the gastrointestinal tract. Improvement of component absorption can also be achieved by designing an appropriate extraction condition.Type: ApplicationFiled: January 18, 2011Publication date: July 21, 2011Applicant: SINOVEDA CANADA, INC.Inventors: Yun Kau TAM, Yi-Chan James LIN, Brian Duff SLOLEY
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Publication number: 20100196979Abstract: A process and system for the conversion of biomass, such as spent brewers grain, into ethanol and other commercial products, such as pelletized fuel, biogas, fertilizer, and livestock feed, is disclosed. The method may include biomass pretreatment, hydrolysis, fermentation, distillation, and dehydration phases.Type: ApplicationFiled: July 28, 2009Publication date: August 5, 2010Applicant: BBI INTERNATIONAL, INC.Inventors: Scott Birkmire, Chris Lindeman, Brian Duff, Jesse Spooner, Mark Yancey
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Publication number: 20080288176Abstract: The present invention provides a method of using a physiologically-based pharmacokinetic model to select a prodrug molecule (NO—X) comprising a therapeutic agent X (e.g. nonsteroidal anti-inflammatory drug, (NSAID)) and an appropriate nitric oxide donor NO. The NSAID can be a non-selective or selective cyclooxygenase inhibitor or other biocompatible compound comprising a carboxyl group. The pharmacokinetic model uses in vitro and/or in silico data to estimate an optimal set of parameters that can predict whether a particular NO—X candidate is capable of producing desirable therapeutic effects, e.g. enhanced anti-inflammatory activity, reduced intestinal, cardiac and renal toxicity. Accordingly, the present invention can greatly enhance proper selection of an appropriate candidate for drug development, thereby minimizing development time and conserving costs.Type: ApplicationFiled: October 13, 2006Publication date: November 20, 2008Inventors: Yun Kau Tam, Christopher Mark Diaper, Hugh A. Semple, Douglas Thacher Ridgway, Yi-Chan James Lin, Brian Duff Sloley
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Publication number: 20040115801Abstract: In one aspect, the invention provides cell cultures and culture conditions that facilitate the establishment of an intestinal epithelial cell culture that has characteristics of the intestinal epithelium, such as: transepithelial electrical resistance, enzyme expression and microvilli morphology. Cell cultures of the invention may use fatty acids such as sodium butyrate and kinase modulators such as 2-{1-[3-(amidinothio)propyl]-1H-indol-3-yl}-3-(1-meethylindol-3-yl)-maleimide methanesulfonate.Type: ApplicationFiled: August 25, 2003Publication date: June 17, 2004Applicant: KINETANA GROUP INC.Inventors: Yi-Chan James Lin, Yun Kau Tam, Hugh Alexander Semple, Brian Duff Sloley