Patents by Inventor Brian Duh-Lan Lee
Brian Duh-Lan Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240139352Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: ApplicationFiled: March 8, 2023Publication date: May 2, 2024Inventors: Faisal Ahmed Syud, Brian Duh-Lan Lee, Rong Zhang, Peter Brian Iveson, Paul Schaffer, Tove Simonsson, Elin Gunneriusson, Fredrik Frejd, Lars Abrahmsen, Joachim Feldwisch, Nina Herne, Christofer Lendel
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Patent number: 11633507Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: GrantFiled: December 10, 2020Date of Patent: April 25, 2023Assignees: GENERAL ELECTRIC COMPANY, AFFIBODY ABInventors: Faisal Ahmed Syud, Brian Duh-Lan Lee, Rong Zhang, Peter Brian Iveson, Paul Schaffer, Tove Simonsson, Elin Gunneriusson, Fredrik Frejd, Lars Abrahmsen, Joachim Feldwisch, Nina Herne, Christofer Lendel
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Publication number: 20230013598Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.Type: ApplicationFiled: September 28, 2022Publication date: January 19, 2023Inventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Antonio Caiafa, Brian Duh-Lan Lee, Allen Lawrence Garner
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Publication number: 20210170057Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: ApplicationFiled: December 10, 2020Publication date: June 10, 2021Inventors: Faisal Ahmed Syud, Brian Duh-Lan Lee, Rong Zhang, Peter Brian Iveson, Paul Schaffer, Tove Simonsson, Elin Gunneriusson, Fredrik Frejd, Lars Abrahmsen, Joachim Feldwisch, Nina Herne, Christofer Lendel
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Patent number: 10894097Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: GrantFiled: September 27, 2018Date of Patent: January 19, 2021Assignees: GENERAL ELECTRIC COMPANY, AFFIBODY ABInventors: Faisal Ahmed Syud, Brian Duh-Lan Lee, Rong Zhang, Peter Brian Iveson, Paul Schaffer, Tove Simonsson, Elin Gunneriusson, Fredrik Frejd, Lars Abrahmsen, Joachim Feldwisch, Nina Herne, Christofer Lendel
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Publication number: 20190262481Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: ApplicationFiled: September 27, 2018Publication date: August 29, 2019Inventors: Faisal Ahmed Syud, Brian Duh-Lan Lee, Rong Zhang, Peter Brian Iveson, Paul Schaffer, Tove Simonsson, Elin Gunneriusson, Fredrik Frejd, Lars Abrahmsen, Joachim Feldwisch, Nina Herne, Christofer Lendel
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Patent number: 10159760Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: GrantFiled: March 29, 2016Date of Patent: December 25, 2018Assignee: General Electric CompanyInventors: Faisal Ahmed Syud, Brian Duh-Lan Lee, Rong Zhang, Peter Brian Iveson, Paul Schaffer, Tove Simonsson, Elin Gunneriusson, Fredrik Frejd, Lars Abrahmsen, Joachim Feldwisch, Nina Herne, Christofer Lendel
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Patent number: 9452199Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.Type: GrantFiled: January 17, 2014Date of Patent: September 27, 2016Assignee: GENERAL ELECTRIC COMPANYInventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Antonio Caiafa, Brian Duh-Lan Lee, Allen Lawrence Garner
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Publication number: 20160199521Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: ApplicationFiled: March 29, 2016Publication date: July 14, 2016Inventors: Faisal Ahmed Syud, Brian Duh-Lan Lee, Rong Zhang, Peter Brian Iveson, Paul Schaffer, Tove Simonsson, Elin Gunneriusson, Fredrik Frejd, Lars Abrahmsen, Joachim Feldwisch, Nina Herne, Christofer Lendel
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Publication number: 20150202264Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.Type: ApplicationFiled: January 17, 2014Publication date: July 23, 2015Applicant: GENERAL ELECTRIC COMPANYInventors: VASILE BOGDAN NECULAES, ANDREW SOLIZ TORRES, ANTONIO CAIAFA, BRIAN DUH-LAN LEE, ALLEN LAWRENCE GARNER
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Patent number: 9078862Abstract: Embodiments of the disclosure relate to platelet activation and/or aggregation using electric pulses. In one embodiment, a platelet-containing sample is exposed to electric pulses. At least one of the electric pulses has a duration greater than 1 microsecond and a field strength below 50 kV/cm. In another embodiment, the electric pulses may be designed with particular field strengths and durations.Type: GrantFiled: June 6, 2013Date of Patent: July 14, 2015Assignee: General Electric CompanyInventors: Vasile Bogdan Neculaes, Antonio Caiafa, Brian Duh-Lan Lee, Nicole Evelyn LaPlante, Andrew Soliz Torres, Allen Lawrence Garner
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Patent number: 8937047Abstract: Provided herein are methods of reducing liver uptake in vivo of a polypeptide that specifically binds to a target comprising: (a) providing a polypeptide that specifically binds to a target; and (b) substituting at least one basic or at least one neutral amino acid residue of the native polypeptide from step (a) with an acidic amino acid residue to produce a modified polypeptide, wherein the modified polypeptide demonstrates an isoelectric point at least 0.05-0.1 pH points less than the isoelectric point of the native polypeptide. Also provided are polypeptides made using the inventive methods as well as imaging techniques that employ the methods and agents.Type: GrantFiled: December 19, 2007Date of Patent: January 20, 2015Assignee: General Electric CompanyInventors: Michael Ernest Marino, Faisal Ahmed Syud, Jason William Castle, Brian Duh-Lan Lee, Malin Lindborg, Elin Gunneriusson, Christofer Lendel
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Publication number: 20140363412Abstract: Embodiments of the disclosure relate to platelet activation and/or aggregation using electric pulses. In one embodiment, a platelet-containing sample is exposed to electric pulses. At least one of the electric pulses has a duration greater than 1 microsecond and a field strength below 50 kV/cm. In another embodiment, the electric pulses may be designed with particular field strengths and durations.Type: ApplicationFiled: June 6, 2013Publication date: December 11, 2014Inventors: Vasile Bogdan Neculaes, Antonio Caiafa, Brian Duh-Lan Lee, Nicole Evelyn LaPlante, Andrew Soliz Torres, Allen Lawrence Garner
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Patent number: 8834839Abstract: Imaging agents that comprise labeled substrates of the cystine/glutamate antiporter of cells, whereby the methods of use comprise introducing the labeled agents into cells via the cystine/glutamate antiporter, which are then reduced to a labeled cysteine, and subsequently detected in the cell.Type: GrantFiled: April 27, 2009Date of Patent: September 16, 2014Assignee: General Electric CompanyInventors: Paul Schaffer, Brian Duh-Lan Lee, Kande Kankanamalage Dayarathna Amarasinghe, Faisal Ahmed Syud, Rong Zhang, Jack Mathew Webster, Jennifer Lynne Huntington
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Patent number: 8784774Abstract: Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.Type: GrantFiled: September 16, 2011Date of Patent: July 22, 2014Assignee: General Electric CompanyInventors: Jack Mathew Webster, Bruce Fletcher Johnson, Brian Duh-Lan Lee, Chittari Pabba, Michael James Rishel
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Publication number: 20130071332Abstract: Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.Type: ApplicationFiled: September 16, 2011Publication date: March 21, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Jack Mathew Webster, Bruce Fletcher Johnson, Brian Duh-Lan Lee, Chittari Pabba, Michael James Rishel
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Publication number: 20120165650Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: ApplicationFiled: December 22, 2010Publication date: June 28, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Faisal Ahmed Syud, Brian Duh-Lan Lee, Rong Zhang, Peter Brian Iveson, Paul Schaffer, Tove Eriksson, Elin Gunneriusson, Fredrik Frejd, Lars Abrahmsen, Joachim Feldwisch, Nina Herne, Christofer Lendel
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Publication number: 20120114563Abstract: The present invention relates to a method of in vivo optical imaging, of the margins around tumours, which comprises an optical imaging contrast agent. The optical imaging agents comprise conjugates of near-infrared dyes with synthetic polyethylene glycol (PEG) polymers having a molecular weight in the range 15-45 kDa. Also disclosed are optical imaging contrast agents, pharmaceutical compositions and kits.Type: ApplicationFiled: March 19, 2010Publication date: May 10, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Randall Lee Carter, Jason William Castle, Kenneth Michael Fish, Anup Sood, Natalie Anne Staples, Brian Duh-Lan Lee
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Patent number: 8124725Abstract: Provided herein are PDGF-R? imaging agents that are polypeptides labeled with a signal generator (e.g., paramagnetic label, a radionuclide, or a fluorophore), wherein the imaging agents bind specifically to PDGFR-?. Also provided are in vivo imaging methods using the imaging agents.Type: GrantFiled: December 17, 2008Date of Patent: February 28, 2012Assignee: General Electric CompanyInventors: Michael Ernest Marino, Faisal Ahmed Syud, Paul Schaffer, Brian Duh-Lan Lee, Rong Zhang, Malin Lindborg, Elin Gunneriusson, Christopher Lendel
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Publication number: 20100272641Abstract: Imaging agents that comprise labeled substrates of the cystine/glutamate antiporter of cells, whereby the methods of use comprise introducing the labeled agents into cells via the cystine/glutamate antiporter, which are then reduced to a labeled cysteine, and subsequently detected in the cell.Type: ApplicationFiled: April 27, 2009Publication date: October 28, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: JACK MATHEW WEBSTER, FAISAL AHMED SYUD, BRIAN DUH-LAN LEE, PAUL SCHAFFER, RONG ZHANG, JENNIFER LYNNE HUNTINGTON, KANDE KANKANAMALAGE DAYARATHNA AMARASINGHE