Abstract: A soft tissue repair system is provided for covering or filling openings in the annulus of an intervertebral disc. The soft tissue repair system uses a single plug or a combination of a first plug and a second plug. The second plug is a flowable plug such as an adhesive material or a material that hardens to a flexible plug material. Each plug is configured to close the opening in the annulus and can be positioned within the opening, over the opening at the exterior surface or over the opening at the interior surface. The plug can also be combined with a clamping mechanism that engages the annulus to secure the plug in the opening.

Abstract: The invention relates to an affinity resin functionalized with small molecule inhibitors of glycoside-cleaving enzymes, e.g., ?-galactosidase A (?-Gal A), glucocerebrosidase (GCB), ?-galactosidase, and acid alpha-glucosidase (GAA), and a method for purifying glycoside-cleaving enzymes produced in a cell line using the small molecule inhibitor-functionalized affinity resin.

Abstract: The invention relates to an affinity resin functionalized with small molecule inhibitors of glycoside-cleaving enzymes, e.g., ?-galactosidase A (?-Gal A), glucocerebrosidase (GCB), ?-galactosidase, and acid alpha-glucosidase (GAA), and a method for purifying glycoside-cleaving enzymes produced in a cell line using the small molecule inhibitor-functionalized affinity resin.

Abstract: Immunoassay devices, systems, and methods described herein measure the presence of analytes of interest in a sample, as well as the presence of sample adequacy markers in a sample. The sample adequacy markers allow for the assessment of the quality, quantity, and composition of the sample. In one aspect, the sample adequacy marker in the sample includes human albumin. In another aspect, the sample adequacy marker in the sample includes lactotransferrin. The immunoassay devices, systems, and methods are able to distinguish between samples that do not contain an analyte of interest, and samples that are of insufficient adequacy to obtain an accurate result. The immunoassay devices, systems, and methods described herein can be implemented as part of a clinical, laboratory, or at-home testing system.

Abstract: Provided is a helical pile having an elongated shaft, at least one helical blade on the shaft having a leading edge and a trailing edge, and a displacement paddle extending outward from the shaft longitudinally positioned between the leading and trailing edges of the blade to push away soil to create a grout channel surrounding the shaft. At least one grout propeller may be provided on the shaft, having at least one blade pitched an opposite direction from the helical blade to propel grout downward in the grout channel as the pile rotates.

Abstract: The invention relates to an affinity resin functionalized with small molecule inhibitors of glycoside-cleaving enzymes, e.g., ?-galactosidase A (?-Gal A), glucocerebrosidase (GCB), ?-galactosidase, and acid alpha-glucosidase (GAA), and a method for purifying glycoside-cleaving enzymes produced in a cell line using the small molecule inhibitor-functionalized affinity resin.

Abstract: Provided herein are methods and kits for detecting environmental contaminants using turbidimetric assays. Certain embodiments of the present disclosure are related to methods of obtaining a sample from a test surface and contacting the collected sample with a turbidimetric composition for quantification of an analyte in the sample.

Abstract: Provided is a helical pile having an elongated shaft, at least one helical blade on the shaft having a leading edge and a trailing edge, and a displacement paddle extending outward from the shaft longitudinally positioned between the leading and trailing edges of the blade to push away soil to create a grout channel surrounding the shaft. At least one grout propeller may be provided on the shaft, having at least one blade pitched an opposite direction from the helical blade to propel grout downward in the grout channel as the pile rotates.

Abstract: Provided is a helical pile having an elongated shaft, at least one helical blade on the shaft having a leading edge and a trailing edge, and a displacement paddle extending outward from the shaft longitudinally positioned between the leading and trailing edges of the blade to push away soil to create a grout channel surrounding the shaft. At least one grout propeller may be provided on the shaft, having at least one blade pitched an opposite direction from the helical blade to propel grout downward in the grout channel as the pile rotates.

Abstract: A system and method for tracking a milk crate, a bread tray, or other instrument for transporting goods of a business makes use of an electronic tracking tag attached to the milk crate, the bread tray, or other transport instrument. The electronic tracking tag includes a microprocessor and a transceiver, and wirelessly transmits an identifying electronic transmission at predetermined time intervals. The systems and methods further make use of a wireless network including a plurality of nodes, where each of the nodes is positioned at a predetermined location and receives the identifying electronic transmission from the electronic tracking tag upon movement of the electronic tracking tag into proximity with a node. Each of the nodes are then connected to a central computer server that identifies a location of the electronic tracking tag based on the predetermined location of the node.

Abstract: Provided is a helical pile having an elongated shaft, at least one helical blade on the shaft having a leading edge and a trailing edge, and a displacement paddle extending outward from the shaft longitudinally positioned between the leading and trailing edges of the blade to push away soil to create a grout channel surrounding the shaft.

Abstract: A building structure is supported above a foundation and above grade by a moment frame comprising a plurality of columns and beams. The columns are all generally similar and the beams are all generally similar, such that each column can be attached with up to four beams. The moment frame is secured to a foundation, which may include pilings extending downwardly into the ground. The foundation can include a concrete foundation member or a foundation framework comprising a plurality of attachment members secured together by beams. The pilings can include helical flighting.

Abstract: A building structure is supported above a foundation and above grade by a moment frame comprising a plurality of columns and beams. The columns are all generally similar and the beams are all generally similar, such that each column can be attached with up to four beams. The moment frame is secured to a foundation, which may include pilings extending downwardly into the ground. The foundation can include a concrete foundation member or a foundation framework comprising a plurality of attachment members secured together by beams. The pilings can include helical flighting.

Abstract: The present disclosure provides an immunoassay involving a multiplex of antibodies that recognize the same analyte but that have a different cross-reactivity to structurally similar compounds. Data obtained from the immunoassay involving observed analyte concentrations is input into an algorithm to determine the true concentration of the analyte in a sample.

Abstract: A wireless communications system is depicted in which a message can be delivered to a wireless device. In the communications system, a first number included within a true address for communication with the device is associated with the device. A second number distinct from the first number is also associated with the device. A communication is received that includes a phantom address, at least a portion of which includes the second number, and a message. The true address is derived by at least deriving the first number from the second number. The message can then be delivered to the device based upon the derived true address.

Abstract: This disclosure relates to LINGO-1 polypeptides, LINGO-1 polypeptide/ligand complexes, crystals of LINGO-1 polypeptides, crystals of LINGO-1 polypeptide/ligand complexes, and related methods and software systems.

Abstract: The present disclosure provides an immunoassay involving a multiplex of antibodies that recognize the same analyte but that have a different cross-reactivity to structurally similar compounds. Data obtained from the immunoassay involving observed analyte concentrations is input into an algorithm to determine the true concentration of the analyte in a sample.

Abstract: This disclosure relates to LINGO-1 polypeptides, LINGO-1 polypeptide/ligand complexes, crystals of LINGO-1 polypeptides, crystals of LINGO-1 polypeptide/ligand complexes, and related methods and software systems.

Abstract: The present invention relates generally to microtiter plate format devices and methods for separating molecules having different net charges. The devices and methods of the invention are particularly suited for use in high-throughput screening to monitor enzymatic reactions which result in a product having an altered net charge. For example, the systems and methods disclosed herein may be used to detect the activity of phosphatases, proteases and kinases on various peptidic substrates under various conditions.

Abstract: Peptide libraries containing peptides having the same net charge or same like charge are described, which may be used to screen for substrates of kinases and phosphatases and any other enzyme that causes a difference in net charge in a suitable substrate. The libraries are designed using representative amino acids for one or more classes of amino acids, thereby reducing the number of members in the peptide library. Reducing the number of peptides in the library to a manageable size permits the peptides to be segregated into individual wells of a microtiter plate, where the sequences of suitable substrates are immediately ascertainable upon exposure to enzyme by detecting the position of charge inverted peptide substrates in the plate.