Patents by Inventor Brian E. Caplin

Brian E. Caplin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Real-time gene quantification with internal standards
    Patent number: 7630837
    Abstract: The present invention is directed to a nucleic acid quantification kit and method for determining the initial concentration or mass fraction of a target nucleic acid present in a sample. Illustrative embodiments include real-time competitive quantitative polymerase chain reaction (PCR) to determine the copy number or mass fraction of a target nucleic acid sequence in a sample and use of a thermodynamically based signal processing algorithm, with or without PCR, to provide mass fraction information.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: December 8, 2009
    Assignees: Idaho Technology, Inc., University of Utah Research Foundation
    Inventors: David J. Eyre, Randy P. Rasmussen, Brian E. Caplin, Wade R. Stevenson, Deepika Marine deSilva
  • Single-labeled oligonucleotide probes for homogeneous nucleic acid sequence analysis
    Patent number: 6635427
    Abstract: Probes and methods are provided for detection and analysis of nucleic acid sequences. The probes are single-labeled oligonucleotide probes whose fluorescence emission changes in response to probe-target hybridization and dissociation. The methods are for analyzing one or multiple nucleic acid loci using the probes. This invention further relates to the use of fluorescence changes in single-labeled probes for melting curve analysis, genotyping, and pathogen detection, and to methods for quantification of specific sequences in real-time monitoring of nucleic acid amplification.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: October 21, 2003
    Assignees: University of Utah Research Foundation, Idaho Technology
    Inventors: Carl T. Wittwer, Andrew O. Crockett, Brian E. Caplin, Wade Stevenson, Jian Chen, Noriko Kusukawa
  • Single-labeled oligonucleotide probes for homogeneous nucleic acid sequence analysis
    Publication number: 20030022177
    Abstract: Probes and methods are provided for detection and analysis of nucleic acid sequences. The probes are single-labeled oligonucleotide probes whose fluorescence emission changes in response to probe-target hybridization and dissociation. The methods are for analyzing one or multiple nucleic acid loci using the probes. This invention further relates to the use of fluorescence changes in single-labeled probes for melting curve analysis, genotyping, and pathogen detection, and to methods for quantification of specific sequences in real-time monitoring of nucleic acid amplification.
    Type: Application
    Filed: August 10, 2001
    Publication date: January 30, 2003
    Inventors: Carl T. Wittwer, Andrew O. Crockett, Brian E. Caplin, Wade Stevenson, Lori A. Wagner, Jian Chen, Noriko Kusukawa