Abstract: A combination of single or cocktails of analgesic, anesthetic, steroid and/or anti-epileptic drug or drugs with a topically applied or injected debridement agent may be used for wounds, burns, scars, Dupuytren's contracture and/or Peyronie's disease to allow for greater removal or breakdown of necrotic/devitalized, infected and/or fibriotic tissue through use of higher agent dose within a greater range of tolerable discomfort.