Patents by Inventor Brian Edmund Burke

Brian Edmund Burke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DISRUPTING THE LINC COMPLEX FOR TREATING LAMINOPATHY
    Publication number: 20200347408
    Abstract: The present invention relates to use of expression vectors and other compounds in methods to disrupt the LInker of Nucleoskeleton and Cytoskeleton (LINC) complex, uncoupling the nucleus from its linkage to the cytoskeleton, resulting in amelioration of diseases caused by one or more Lmna mutations, so-called laminopathies. More particularly, the invention relates to the expression of dominant negative SUN domain protein and/or dominant negative KASH domain protein to disrupt, for example, the LINC complex in cardiomyocytes for suppressing disease progression in dilated cardiomyopathy (DCM).
    Type: Application
    Filed: January 18, 2019
    Publication date: November 5, 2020
    Applicant: Agency for Science, Technology and Research
    Inventors: Colin Lawson Stewart, Jinfen Chai, Yin Loon Lee, Brian Edmund Burke