Patents by Inventor Brian Edward Kalmbach

Brian Edward Kalmbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ARTIFICIAL EXPRESSION CONSTRUCTS FOR MODULATING GENE EXPRESSION IN CHANDELIER CELLS
    Publication number: 20240018543
    Abstract: Artificial expression constructs for modulating gene expression in targeted central nervous system cell types are described. The artificial expression constructs can be used to express synthetic genes or modify gene expression in chandelier cells. Chandelier cells are a subtype of GABAergic interneurons that that have been implicated in disorders such as epilepsy and schizophrenia.
    Type: Application
    Filed: November 10, 2021
    Publication date: January 18, 2024
    Applicant: Allen Institute
    Inventors: Tanya Daigle, Lucas T. Graybuck, Brian Edward Kalmbach, Edward Sebastian Lein, John K. Mich, Boaz P. Levi, Adriana Estela Sedeño Cortés, Bosiljka Tasic, Jonathan Ting, Hongkui Zeng
  • ARTIFICIAL EXPRESSION CONSTRUCTS FOR SELECTIVELY MODULATING GENE EXPRESSION IN NEOCORTICAL LAYER 5 GLUTAMATERGIC NEURONS
    Publication number: 20230159952
    Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. Particularly, the artificial expression constructs can be used to selectively express synthetic genes and/or modify gene expression in neocortical glutamatergic layer 5 neurons, such as glutamatergic layer 5 extratelencephalic-projecting (L5 ET) neurons.
    Type: Application
    Filed: April 21, 2021
    Publication date: May 25, 2023
    Applicant: ALLEN INSTITUTE
    Inventors: Tanya Daigle, Lucas T. Graybuck, Brian Edward Kalmbach, Edward Sebastian Lein, Boaz P. Levi, John K. Mich, Adriana Estela Sedeño Cortés, Bosiljka Tasic, Jonathan Ting, Hongkui Zeng
  • ARTIFICIAL EXPRESSION CONSTRUCTS FOR SELECTIVELY MODULATING GENE EXPRESSION IN EXCITATORY CORTICAL NEURONS
    Publication number: 20210395780
    Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in excitatory cortical neurons, such as primarily within cortical layers 2/3, 4, 5, and 6 and including those with extratelencephalic (ET) projections, intratelencephalic (IT) projections, and pyramidal tract (PT) projections, among others.
    Type: Application
    Filed: November 5, 2019
    Publication date: December 23, 2021
    Applicant: Allen Institute
    Inventors: Lucas T. Graybuck, Bosiljka Tasic, Tanya Daigle, Jonathan Ting, Hongkui Zeng, Brian Edward Kalmbach, John K. Mich, Erik Hess, Edward Sebastian Lein, Boaz P. Levi