Patents by Inventor Brian Edward Oeffinger

Brian Edward Oeffinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF FREEZE DRYING SURFACTANT-STABILIZED MICROBUBBLES
    Publication number: 20230044615
    Abstract: One aspect of the invention provides a method for freeze-drying surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; partially submerging the vials in a chilled water bath, wherein the water bath has a sub-freezing temperature; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials. Another aspect of the invention provides a method for annealing surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; passing the vials in and out of liquid nitrogen (LN2) until the mixture is frozen; holding the vials at ?20° C.; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials.
    Type: Application
    Filed: June 30, 2022
    Publication date: February 9, 2023
    Applicants: Thomas Jefferson University, Drexel University
    Inventors: Brian Edward Oeffinger, Margaret A. Wheatley, Rawan Shraim, Purva Vaidya, John Robert Eisenbrey
  • Method of freeze drying surfactant-stabilized microbubbles
    Patent number: 11389552
    Abstract: One aspect of the invention provides a method for freeze-drying surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; partially submerging the vials in a chilled water bath, wherein the water bath has a sub-freezing temperature; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials. Another aspect of the invention provides a method for annealing surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; passing the vials in and out of liquid nitrogen (LN2) until the mixture is frozen; holding the vials at ?20° C.; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: July 19, 2022
    Assignees: Thomas Jefferson University, Drexel University
    Inventors: Brian Edward Oeffinger, Margaret A. Wheatley, Rawan Shraim, Purva Vaidya, John Robert Eisenbrey
  • METHOD OF FREEZE DRYING SURFACTANT-STABILIZED MICROBUBBLES
    Publication number: 20200289679
    Abstract: One aspect of the invention provides a method for freeze-drying surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; partially submerging the vials in a chilled water bath, wherein the water bath has a sub-freezing temperature; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials. Another aspect of the invention provides a method for annealing surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; passing the vials in and out of liquid nitrogen (LN2) until the mixture is frozen; holding the vials at ?20° C.; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials.
    Type: Application
    Filed: March 13, 2020
    Publication date: September 17, 2020
    Inventors: Brian Edward Oeffinger, Margaret A. Wheatley, Rawan Shraim, Purva Vaidya, John Robert Eisenbrey