Abstract: Antibody molecules that specifically bind to NKp30 are disclosed. The anti-NKp30 antibody molecules can be used to treat, prevent and/or diagnose cancerous, autoimmune or infectious conditions and disorders.

Abstract: The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.

Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in excitatory cortical neurons, such as primarily within cortical layers 2/3, 4, 5, and 6 and including those with extratelencephalic (ET) projections, intratelencephalic (IT) projections, and pyramidal tract (PT) projections, among others.

Abstract: The invention relates to a cosmetic applicator (101) comprising: a mounting rod (1) and a applicator device (2) arranged at an end (11) of the mounting rod (1). The applicator device comprises a first applicator element (21) and a second applicator element (22). The first applicator element (21) includes a first material, and the second applicator element (22) includes a second material, the first material having a hardness lower than the hardness of the second material, and wherein the first applicator element (21) and the second applicator element (22) are fixed on the end (11) of the mounting rod (1) at different sides of the mounting rod.

Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: An apparatus for supporting a user includes a faceplate, an arm, a bridge, and a base. The bridge is rotatably attached to the faceplate to allow the faceplate to be pivotably adjusted. The bridge includes a hub with first and second hub bodies. Locking pins on the hub bodies slidingly engage pivot adjustment holes in first and second pivot adjustment rings. First and second buttons can be depressed to slide the hub bodies inwardly to separate the locking pins from the pivot adjustment holes to allow the hub to rotate, thereby allowing the faceplate to pivot. When the buttons are released, the hub bodies slide outwardly to insert the locking pins into the same or different pivot adjustment holes to prevent the hub from rotating.

Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: Provided, in part, are compounds of Formula I. pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with the activity of sodium channels. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: The same test data frame is dispatched from a network interface device a plurality of times so as to test a network. Since the same test data frame is used, it may be unnecessary for a new test data frame to be provided and protocol processed each time one is required to be sent. The protocol processing resources of the network interface device are then available for sending further traffic in parallel with the dispatch of the test data frames. On the receive side, the network interface device collects statistics regarding the reliable receipt of test frames, without requiring the test frames to be further processed and provided to a driver of the network interface device. In this way, the processing and buffering capacity in the network interface device is available for handling further traffic in parallel with the test traffic.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

Abstract: The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.

Abstract: The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.

Abstract: A roof integrated photovoltaic system includes a starter bar having a foot base and configured to be installed to a roof deck, a plurality of water shedding layers, and a photovoltaic module. One of the plurality of water shedding layers is configured to be installed over the foot base of the starter bar, and one of another of which is configured to overlap and be installed over the one of the plurality of water shedding layers. The system further includes a foot module configured to be attached to an upper portion of the photovoltaic module. A lower portion of the photovoltaic module is configured to align with the foot base of the starter bar, and the foot module is configured to be affixed on a last overlapping layer of the plurality of water shedding layers to the roof deck.

Abstract: Systems and methods are described for optical processing. According to some aspects an optical processing apparatus may include a pixelated photodiode array (PDA), each pixel in the PDA includes a radiation detector. The apparatus also includes a read out integrated circuit (ROIC) that includes a logic circuit and a plurality of switch elements. The plurality of switch elements being switchable between an armed state for arming its corresponding radiation detector and transmitting a signal received from the corresponding detector to the ROIC, and a disarmed state for disarming its corresponding detector and blocking transmittal of the signal, wherein in the armed state, the PDA is configured to detect an incoming optical signal and in the disarmed state, the PDA is configured to disregard the incoming optical signal. Moreover, the logic circuit controls a switch state of a selectable switch element associated with a radiation detector.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: One aspect of the invention provides a method for freeze-drying surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; partially submerging the vials in a chilled water bath, wherein the water bath has a sub-freezing temperature; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials. Another aspect of the invention provides a method for annealing surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; passing the vials in and out of liquid nitrogen (LN2) until the mixture is frozen; holding the vials at ?20° C.; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials.

Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: Provided, in part, are compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with the activity of sodium channels. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: Systems and methods for determining playback times for content items presented in playlists are disclosed. Techniques described herein include identifying a first content item in a content reel comprising a plurality of content items, and determining that the first content item has an undefined display duration. In response to the first content item having an undefined display duration, a display duration for which the first content item should be displayed when presented in the content reel is calculated. The content reel can be provided for display at a client device, such that the first content item is displayed for the display duration.

Abstract: One or more bits of the destination MAC address indicate a number of times a reset event has occurred. These bits may be referred to as a generation number. The generation number in a destination MAC address is updated when a reset event occurs. In this way, frames issued by the sender prior to the reset may be distinguished from frames issued after the reset, since the destination MAC addresses in those frames will not match. In this way, the recipient device is protected from stale packets.