Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: Systems and methods are described for optical processing. According to some aspects an optical processing apparatus may include a pixelated photodiode array (PDA), each pixel in the PDA includes a radiation detector. The apparatus also includes a read out integrated circuit (ROIC) that includes a logic circuit and a plurality of switch elements. The plurality of switch elements being switchable between an armed state for arming its corresponding radiation detector and transmitting a signal received from the corresponding detector to the ROIC, and a disarmed state for disarming its corresponding detector and blocking transmittal of the signal, wherein in the armed state, the PDA is configured to detect an incoming optical signal and in the disarmed state, the PDA is configured to disregard the incoming optical signal. Moreover, the logic circuit controls a switch state of a selectable switch element associated with a radiation detector.

Abstract: A roof integrated photovoltaic system includes a starter bar having a foot base and configured to be installed to a roof deck, a plurality of water shedding layers, and a photovoltaic module. One of the plurality of water shedding layers is configured to be installed over the foot base of the starter bar, and one of another of which is configured to overlap and be installed over the one of the plurality of water shedding layers. The system further includes a foot module configured to be attached to an upper portion of the photovoltaic module. A lower portion of the photovoltaic module is configured to align with the foot base of the starter bar, and the foot module is configured to be affixed on a last overlapping layer of the plurality of water shedding layers to the roof deck.

Abstract: One aspect of the invention provides a method for freeze-drying surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; partially submerging the vials in a chilled water bath, wherein the water bath has a sub-freezing temperature; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials. Another aspect of the invention provides a method for annealing surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; passing the vials in and out of liquid nitrogen (LN2) until the mixture is frozen; holding the vials at ?20° C.; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials.

Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: Provided, in part, are compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with the activity of sodium channels. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: Systems and methods for determining playback times for content items presented in playlists are disclosed. Techniques described herein include identifying a first content item in a content reel comprising a plurality of content items, and determining that the first content item has an undefined display duration. In response to the first content item having an undefined display duration, a display duration for which the first content item should be displayed when presented in the content reel is calculated. The content reel can be provided for display at a client device, such that the first content item is displayed for the display duration.

Abstract: One or more bits of the destination MAC address indicate a number of times a reset event has occurred. These bits may be referred to as a generation number. The generation number in a destination MAC address is updated when a reset event occurs. In this way, frames issued by the sender prior to the reset may be distinguished from frames issued after the reset, since the destination MAC addresses in those frames will not match. In this way, the recipient device is protected from stale packets.

Abstract: A medical imaging system includes a CT imaging system including a gantry having a bore, rotatable about an axis of rotation. The CT imaging system includes a table configured to move a subject to be imaged into and out of the bore, a radiation source mounted on the gantry and configured to emit an X-ray beam, and a detector configured to detect the X-ray beam. The medical imaging system includes a LiDAR scanning system physically coupled to the CT imaging system. The LiDAR scanning system is configured to acquire data of the subject from different angular positions relative to the axis of rotation. The medical imaging system includes processing circuitry configured to receive the data acquired with the LiDAR scanning system, to generate a three-dimensional (3D) measurement of the subject, and to utilize the 3D measurement in a subsequent workflow process for a CT scan of the subject.

Abstract: A method includes receiving data acquired with a light detection and ranging (LiDAR) scanning system physically coupled to a computed tomography (CT) imaging system of a subject to be imaged disposed on a cradle of a table, wherein the table is configured to move the subject into and out of a bore of a gantry of the CT imaging system. The method also includes generating a multi-dimensional avatar of the subject representing a topography of the subject. The method further includes causing display of the multi-dimensional avatar positioned on the cradle that represents a current position of the subject on the display, wherein the display is disposed adjacent the table within view of the subject. The method even further includes providing instructions on the display to enable the subject to guide themselves to a target position on the cradle for a CT scan with the CT imaging system.

Abstract: Provided herein are nucleic acid constructs, polypeptides and T cells related to antigen binding domains that bind to mutant calreticulin; and methods of use thereof for the treatment of diseases, including cancer.

Abstract: Multispecific molecules that include a first tumor-targeting moiety; a second tumor-targeting moiety; and one, two or all of: an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); a cytokine molecule or a modulator of a cytokine molecule; and/or a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: Wearable systems and method for operation thereof incorporating headset and controller localization using headset cameras and controller fiducials are disclosed. A wearable system may include a headset and a controller. The wearable system may alternate between performing headset tracking and performing controller tracking by repeatedly capturing images using a headset camera of the headset during headset tracking frames and controller tracking frames. The wearable system may cause the headset camera to capture a first exposure image an exposure above a threshold and cause the headset camera to capture a second exposure image having an exposure below the threshold. The wearable system may determine a fiducial interval during which fiducials of the controller are to flash at a fiducial frequency and a fiducial period. The wearable system may cause the fiducials to flash during the fiducial interval in accordance with the fiducial frequency and the fiducial period.

Abstract: Disclosed herein is a data storage device. A data port transmits data between a host computer system and the data storage device. A non-volatile storage medium stores encrypted user content data and a cryptography engine connected between the data port and the storage medium uses a cryptographic key to decrypt the encrypted user content data. Multiple manager device records each comprise a first key identical for each of the records, and a second key that different for each of the records. The controller generates an authorization request using the first key and receives a response to the request generated by a manager device. The response is specific to that manager device. The controller uses the response to locate the record; decrypts the located manager device record to obtain key data; and generates configuration data based on the key data to register the device.

Abstract: Systems and methods are described for optical processing. According to some aspects an optical processing apparatus may include a pixelated photodiode array (PDA), each pixel in the PDA includes a radiation detector. The apparatus also includes a read out integrated circuit (ROIC) that includes a logic circuit and a plurality of switch elements. The plurality of switch elements being switchable between an armed state for arming its corresponding radiation detector and transmitting a signal received from the corresponding detector to the ROIC, and a disarmed state for disarming its corresponding detector and blocking transmittal of the signal, wherein in the armed state, the PDA is configured to detect an incoming optical signal and in the disarmed state, the PDA is configured to disregard the incoming optical signal. Moreover, the logic circuit controls a switch state of a selectable switch element associated with a radiation detector.

Abstract: The present disclosure provides a method for forming a semiconductor device containing MOS transistors both with and without source/drain extension regions in a semiconductor substrate having a semiconductor material on either side of a gate structure including a gate electrode on a gate dielectric formed in a semiconductor material. In devices with source/drain extensions, a diffusion suppression species of one or more of indium, carbon and a halogen are used. The diffusion suppression implant can be selectively provided only to the semiconductor devices with drain extensions while devices without drain extensions remain diffusion suppression implant free.

Abstract: Systems and methods are disclosed for determining a hydraulic fracture aperture within a subsurface region of interest. The methods may include obtaining, from a wellbore imaging tool, an image of a portion of a wellbore wall, wherein the wellbore penetrates the subsurface region of interest, obtaining, from a sonic logging tool, a full waveform sonic dataset for the portion, and identifying, using a well log interpretation system, a location of each member of a plurality of fractures in the image. The method may further include using a full waveform sonic processing system, for each member of the plurality of fractures, identifying a reflected sonic signal originating at the location of the fractures, and determining, from the reflected sonic signal, a hydraulic aperture.

Abstract: An electrical power pulse generator system and a method of the system's operation are described herein. A main energy storage capacitor supplies a negative DC power and a kick energy storage capacitor supplies a positive DC power. A main pulse power transistor is interposed between the main energy storage capacitor and an output pulse rail and includes a main power transmission control input for controlling power transmission from the main energy storage capacitor to the output pulse rail. A positive kick pulse power transistor is interposed between the kick energy storage capacitor and the output pulse rail and includes a kick power transmission control input for controlling power transmission from the kick energy storage capacitor to the output pulse rail. A positive kick pulse power transistor control line is connected to the kick power transmission control input of the positive kick pulse transistor.

Abstract: Systems and methods are provided for computed tomography (CT) imaging. In one embodiment, a method comprises adaptively blending at least two input image volumes with different spatially-variant noise characteristics to generate an output image volume with uniform noise throughout the output image volume. In this way, images may be reconstructed from projection data with data redundancy without introducing image artifacts from stitching images or variance in image noise due to the data redundancy.

Abstract: Disclosed herein are clot treatment systems including integrated/systemized mechanical thrombectomy devices and clot treatment devices, and associated devices and methods. In some embodiments, a method of removing clot material from a blood vessel of patient includes inserting a catheter to proximate the clot material within the blood vessel while radially constraining a clot treatment device and an embolic protection device within the catheter. The method can further include moving the catheter proximally to deploy the clot treatment device at least partially distal to clot material within the blood vessel, and then moving the catheter further proximally to deploy the embolic protection device at least partially proximal to the clot material.