Abstract: There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

Abstract: Methods and systems for managing a network using a handheld communications device are provided. The methods and systems provide advantages for Network Administrators that require mobility in accessing information about network connected devices and for controlling selected network management functions.

Abstract: The present invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5?-methylthioadenosine phosphorylases (MTAP), 5?-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

Abstract: The present invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5?-methylthioadenosine phosphorylases (MTAP), 5?-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

Abstract: This invention relates to compounds that are analogues of coformycin, pharmaceutical compositions containing the compounds, and methods of using the compounds for treating protozoan parasite infections, especially malaria.

Abstract: Methods and apparatus are described by which media assets may be prioritized and published in accordance with current topics of interest derived from a dynamic data set representing the online activity of a relevant population of users.

Abstract: There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

Abstract: There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

Abstract: The present invention relates to indazolo-tetrahydropyrimidine-carboxamide derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such indazolo-tetrahydropyrimidine-carboxamide derivatives are useful in the treatment of diseases associated with inappropriate ROCK-1 kinase.

Abstract: The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5?-methylthioadenosine phosphorylases (MTAP), 5?-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

Abstract: A host securely transmits content to a peripheral thereof. The peripheral has a symmetric key (PK) and a copy of (PK) encrypted according to a public key (PU) of an entity ((PU(PK))). In the method, the host receives (PU(PK)) from the peripheral, and sends (PU(PK)) to the entity. The entity has a private key (PR) corresponding to (PU), applies (PR) to (PU(PK)) to obtain (PK), and sends (PK) back to the host. The host receives (PK) from the entity, encrypts at least a portion of the content according to (PK), and transmits the encrypted content to the peripheral. The peripheral may then decrypt the encrypted content based on (PK). A bind key (BK) encrypted by (PK) ((PK(BK))) may accompany (PU(PK)), where the content is to be encrypted according to (BK). Thus, (PK) is not revealed to the host.

Abstract: Embodiments of a closed-contact electroplating cup assembly that may be rapidly cleaned while an electroplating system is on-line are disclosed. One disclosed embodiment comprises a cup assembly and a cone assembly, wherein the cup assembly comprises a cup bottom comprising an opening, a seal surrounding the opening, an electrical contact structure comprising a plurality of electrical contacts disposed around the opening, and an interior cup side that is tapered inwardly in along an axial direction of the cup from a cup top toward the cup bottom.

Abstract: A host securely transmits content to a peripheral thereof. The peripheral has a symmetric key (PK) and a copy of (PK) encrypted according to a public key (PU) of an entity ((PU(PK))). In the method, the host receives (PU(PK)) from the peripheral, and sends (PU(PK)) to the entity. The entity has a private key (PR) corresponding to (PU), applies (PR) to (PU(PK)) to obtain (PK), and sends (PK) back to the host. The host receives (PK) from the entity, encrypts at least a portion of the content according to (PK), and transmits the encrypted content to the peripheral. The peripheral may then decrypt the encrypted content based on (PK). A bind key (BK) encrypted by (PK) ((PK(BK))) may accompany (PU(PK)), where the content is to be encrypted according to (BK). Thus, (PK) is not revealed to the host.

Abstract: A process is disclosed for preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (I), or (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (Ia) involving, as a key step, the enzyme-catalysed enantioselective hydrolysis of a racemic 3,4-trans-disubstituted pyrrolidinone compound of formula (II).

Abstract: The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.

Abstract: The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.

Abstract: A high temperature blocking gel contains a blend of an aqueous fluid and carboxymethyl guar and a crosslinking agent. The gel exhibits excellent hydration capability in brines and positive viscosity generation and controls fluid loss from an oil well during drilling, completion and/or workover operations.

Abstract: Techniques are described for processing computerized images with a graphics processing unit (GPU) using an extended vertex cache. The techniques include creating an extended vertex cache coupled to a GPU pipeline to reduce an amount of data passing through the GPU pipeline. The GPU pipeline receives an image geometry for an image, and stores attributes for vertices within the image geometry in the extended vertex cache. The GPU pipeline only passes vertex coordinates that identify the vertices and vertex cache index values that indicate storage locations of the attributes for each of the vertices in the extended vertex cache to other processing stages along the GPU pipeline. The techniques described herein defer the setup of attribute gradients to just before attribute interpolation in the GPU pipeline. The vertex attributes may be retrieved from the extended vertex cache for attribute gradient setup just before attribute interpolation in the GPU pipeline.

Abstract: Technology for protecting a digital content including a first content protection system capable of decrypting the digital content, the digital content including an inclusion list; a linkable library providing access for an application to the functionality of the first content protection system, the application including a second content protection system; and a means for evaluating the second content protection system to determine if the second content protection system is on the inclusion list.

Abstract: A roller may have a roller cylinder having two ends and an axle assembly in at least one end of the roller cylinder. The axle assembly has an axle stub extending out from the roller cylinder and rotatably mounted therein by two spaced-apart bearings. In another aspect, an axle cartridge for a roller includes a sleeve having a length and having two ends and two bearings mounted in the sleeve, spaced-apart from each other. An axle stub is mounted in the bearings for rotation relative to the sleeve, the axle stub being configured to protrude from the sleeve. A roller may be manufactured by mounting an axle cartridge as described herein in each end of a roller cylinder.