Patents by Inventor Brian Felice

Brian Felice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HTT REPRESSORS AND USES THEREOF
    Publication number: 20220064237
    Abstract: Disclosed herein are HTT repressors and methods and compositions for use of these HTT repressors. Disclosed herein are methods and compositions for diagnosing, preventing and/or treating Huntington's Disease. In particular, provided herein are methods and compositions for modifying (e.g., modulating expression of) an HD HTT allele so as to prevent or treat Huntington Disease, including mHTT repressors (that repress mHTT transcripts and thus also repress mHTT protein expression).
    Type: Application
    Filed: January 15, 2020
    Publication date: March 3, 2022
    Inventors: Galen Carey, Matthew Chiocco, Vivian Choi, Brian Felice, Steven Froelich, Debra Klatte, Jeffrey Miller, David Paschon, Edward Rebar, Bryan Zeitler, Lei Zhang, H. Steve Zhang
  • Subcutaneous administration of iduronate-2-sulfatase
    Patent number: 9603908
    Abstract: The present invention provides, among other things, compositions, kits and methods for subcutaneous delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention provides methods for treating Hunter syndrome by subcutaneous administration of a replacement iduronate-2-sulfatase (I2S) protein. In some embodiments, the present invention provides a kit comprising an arrangement of components for subcutaneously administering iduronate-2-sulfatase (I2S) protein.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 28, 2017
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventors: Hongsheng Xie, Brian Felice, Thomas McCauley
  • METHODS OF TREATING B2-BRADYKININ RECEPTOR MEDIATED ANGIOEDEMA
    Publication number: 20160030416
    Abstract: Methods of treating B2-bradykinin receptor mediated angioedema in a subject by administering a composition containing a 8-(heteroarylmethoxy)quinolone compound, a 8-(arylmethoxy)quinoline compound, or a salt, a stereoisomer, a hydrate, or a solvate thereof. Oral formulations containing a 8-(heteroarylmethoxy)quinolone compound, a 8-(arylmethoxy)quinoline compound, or a salt, a stereoisomer, a hydrate, or a solvate thereof for the treatment of B2-bradykinin receptor mediated angioedema. Use of a composition containing a 8-(heteroarylmethoxy)quinolone compound, a 8-(arylmethoxy)quinoline compound, or a salt, a stereoisomer, a hydrate, or a solvate thereof for the manufacture of a medicament for the treatment and/or prevention of a B2-bradykinin receptor mediated angioedema.
    Type: Application
    Filed: March 12, 2014
    Publication date: February 4, 2016
    Inventors: Kevin Leach, Teresa Wright, Brian Felice, Richard Pfeifer, Pericles Calias, Thomas McCauley
  • SUBCUTANEOUS ADMINISTRATION OF IDURONATE- 2-SULFATASE
    Publication number: 20150086526
    Abstract: The present invention provides, among other things, compositions, kits and methods for subcutaneous delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention provides methods for treating Hunter syndrome by subcutaneous administration of a replacement iduronate-2-sulfatase (I2S) protein. In some embodiments, the present invention provides a kit comprising an arrangement of components for subcutaneously administering iduronate-2-sulfatase (I2S) protein.
    Type: Application
    Filed: March 14, 2013
    Publication date: March 26, 2015
    Inventors: Hongsheng Xie, Brian Felice, Thomas McCauley
  • Methods for treating lysosomal acid lipase deficiency
    Patent number: 8945542
    Abstract: The present invention provides compositions and methods for effective treatment of a lysosomal acid lipase deficiency (LALD) disease, in particular, Wolman's disease and Cholesteryl Ester Storage Disease (CESD). Among other things, the present invention provides a method of treating developmental impairment or malnutrition in an individual suffering from a lysosomal acid lipase deficiency (LALD) disease, comprising administering to the individual a therapeutic effective amount of a lysosomal acid lipase.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: February 3, 2015
    Assignee: Synageva Biopharma Corp.
    Inventors: Michael Heartlein, Michael Concino, Paolo Martini, Muthuraman Meiyappan, Pericles Calias, Alla Romashko, Brian Pescatore, Lawrence Charnas, Jan Powell, Brian Felice, Nancy Savioli
  • METHODS FOR TREATING LYSOSOMAL ACID LIPASE DEFICIENCY
    Publication number: 20140044697
    Abstract: The present invention provides compositions and methods for effective treatment of a lysosomal acid lipase deficiency (LALD) disease, in particular, Wolman's disease and Cholesteryl Ester Storage Disease (CESD). Among other things, the present invention provides a method of treating developmental impairment or malnutrition in an individual suffering from a lysosomal acid lipase deficiency (LALD) disease, comprising administering to the individual a therapeutic effective amount of a lysosomal acid lipase.
    Type: Application
    Filed: August 14, 2013
    Publication date: February 13, 2014
    Applicant: Synageva Biopharma Corp.
    Inventors: Michael Heartlein, Michael Concino, Paolo Martini, Muthuraman Meiyappan, Pericles Calias, Alla Romashko, Brian Pescatore, Lawrence Charnas, Jan Powell, Brian Felice, Nancy Savioli