Abstract: Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro. Specifically, the disclosure is directed to a prenyltransferase variant, a chimeric prenyltransferase comprising one or more portions of at least two different prenyltransferase proteins, and a fusion polypeptide comprising a CBG-type producing prenyltransferase and farnesyl pyrophosphate synthase.

Abstract: Method, computer program product, and computer system are provided. A first migration of a running logical partition (LPAR) is performed from a first-generation computer to a second-generation computer. Availability of a facility differs between the first- and second-generation computers. Upon completion of the first migration, an operating system of the running LPAR detects whether a required facility in use on the first-generation computer is available on the second-generation computer. Operating system takes an action to continue an orderly execution of the LPAR, the operating system, and threads of an application in the LPAR depending on the availability of the required facility. A second migration is performed of the running LPAR from the second-generation computer back to the first-generation computer. The required facility is available on the first-generation computer. The operating system restores access to threads of the application to the required facility.

Abstract: Embodiments of the present invention encompass systems and methods for delivering ligatures to anatomical features of a patient. Exemplary ligature delivery systems for use in delivering a ligature to a left atrial appendage ligature include an elongate support mechanism having a proximal portion and a distal portion, a flexible hoop assembly, and a cinchable constriction member. The flexible hoop assembly can be coupled with the distal portion of the elongate support mechanism, and can include a support body coupled with a support frame. The support frame can be biased to hold the support body in a trailing configuration, whereby a free portion of the support body is disposed proximal to the distal portion of the elongate support mechanism. The support frame of the flexible hoop assembly can be coupled with the distal portion of the elongate support mechanism. The support body can be configured to support the cinchable constriction member and a loop of the left atrial appendage ligature.

Abstract: Embodiments of the present invention encompass systems and methods for delivering ligatures to anatomical features of a patient. Exemplary ligature delivery systems for use in delivering a ligature to a left atrial appendage ligature include an elongate support mechanism having a proximal portion and a distal portion, a flexible hoop assembly, and a cinchable constriction member. The flexible hoop assembly can be coupled with the distal portion of the elongate support mechanism, and can include a support body coupled with a support frame. The support frame can be biased to hold the support body in a trailing configuration, whereby a free portion of the support body is disposed proximal to the distal portion of the elongate support mechanism. The support frame of the flexible hoop assembly can be coupled with the distal portion of the elongate support mechanism. The support body can be configured to support the cinchable constriction member and a loop of the left atrial appendage ligature.

Abstract: An example system for applying an occlusion clip to an anatomical structure may include a visualization tool configured to allow visualization of an anatomical structure using a scope; a clip applier configured to apply an occlusion clip on the anatomical structure; an introducer connectable to the clip applier and configured to aid in positioning the clip applier; and a positioner configured to apply at least one of a linear force and a torsional force to at least one of the clip applier and the clip.

Abstract: Medical devices are disclosed. An example surgical spacemaking device may include an elongate element configured for insertion into a patient's body and including a distal end portion and an internal lumen, an inner element disposed generally coaxially within the internal lumen of the elongate element, an expandable element disposed generally circumferentially about a distal end portion of the inner element, and an actuator operable to reposition the expandable element between a contracted configuration and an expanded configuration. In the contracted configuration, the expandable element may have a relatively small diameter and, in the expanded configuration, the expandable element may have a relatively large diameter.

Abstract: Embodiments of the present invention encompass systems and methods for delivering ligatures to anatomical features of a patient. Exemplary ligature delivery systems for use in delivering a ligature to a left atrial appendage ligature include an elongate support mechanism having a proximal portion and a distal portion, a flexible hoop assembly, and a cinchable constriction member. The flexible hoop assembly can be coupled with the distal portion of the elongate support mechanism, and can include a support body coupled with a support frame. The support frame can be biased to hold the support body in a trailing configuration, whereby a free portion of the support body is disposed proximal to the distal portion of the elongate support mechanism. The support frame of the flexible hoop assembly can be coupled with the distal portion of the elongate support mechanism. The support body can be configured to support the cinchable constriction member and a loop of the left atrial appendage ligature.