Abstract: A medical device includes a handle having a first end and a second end, a mixer positioned within the handle and an adapter coupled to the second end of the handle. A delivery needle includes a distal end, a proximal end, and a lumen extending from the distal end to the proximal end. The proximal end of the delivery needle is coupled to the first end of the handle. A sensor cable includes a distal end and a proximal end, and the proximal end of the sensor cable is positioned within the handle, and the distal end extends distally through the lumen of the delivery needle.

Abstract: A system includes a medical device and computer-readable media storing instructions that, when executed by a processor, cause operations to be performed, including: receiving a three-dimensional (3D) image of anatomy, processing the 3D image to extract a 3D model identifying anatomical structures of interest, receiving images captured by an imaging device of the medical device as the medical device is navigated through a body lumen to a target site, including a current image of the target site, receiving medical device spatial information from a position sensing system including a transmitter/receiver in or on the medical device, processing the images and spatial information to generate a 3D surface map of the body lumen, registering the 3D model to the patient using the map and spatial information, and generating and displaying a graphical user interface overlaying a representation of a position/trajectory of the anatomical structures of interest on the current image.

Abstract: Systems and methods for isolating and/or desiccating a portion of a drug delivery tract of a drug delivery apparatus to reduce water vapor content therein are provided. For example, there is provided a metered dose inhaler for delivering aerosolized medicament or other matter to a user. The aerosolized medicament or other matter may be discharged from a discharge passageway within the inhaler into an inhalation passageway for inhalation by a user, and the inhaler may comprise a seal member operative to selectively isolate the discharge passageway from the inhalation passageway and external environment during inactivity. The inhaler may further comprise a desiccant material arranged to withdraw moisture from the isolated discharge passageway. In other instances, desiccant material may be arranged to withdraw moisture from the discharge passageway of the inhaler without isolating the discharge passage during inactivity.

Abstract: A battery charger may include a housing including a plurality of battery bays and a plurality of charging indicators, each associated with a respective battery bay. The plurality of battery bays and the plurality of charging indicators may be located on an angled top side surface of the housing. The charger may be configured to be selectively mounted in a first position with a bottom side surface of the housing on a horizontal surface and in a second position with the bottom side surface on a vertical wall. The vertical wall may be approximately perpendicular to the horizontal surface. A viewing angle of the angled top side surface from a perspective along a horizontal plane parallel to the horizontal surface may be between approximately 120 degrees and approximately 150 degrees when the charger is located in either of the first position and the second position.

Abstract: A reusable tip for minimally invasive surgical instruments can include an end effector, a two-part hub, and a yoke. The end effector can include one or more movable portions enabling the end effector to move between first (e.g., open) and second (e.g., closed) positions via manipulation of the yoke within the hub. The hub can include a proximal hub and a distal hub coupled together. The end effector can be coupled to the distal hub, which can be made of a metal to provide high strength and secure shape to the distal hub. The proximal hub can be made of an autoclavable insulation material capable of maintaining a removable coupling with a control shaft. The proximal hub can be made of polyetheretherketone (PEEK).

Abstract: Systems and methods for isolating and/or desiccating a portion of a drug delivery tract of a drug delivery apparatus to reduce water vapor content therein are provided. For example, there is provided a metered dose inhaler for delivering aerosolized medicament or other matter to a user. The aerosolized medicament or other matter may be discharged from a discharge passageway within the inhaler into an inhalation passageway for inhalation by a user, and the inhaler may comprise a seal member operative to selectively isolate the discharge passageway from the inhalation passageway and external environment during inactivity. The inhaler may further comprise a desiccant material arranged to withdraw moisture from the isolated discharge passageway. In other instances, desiccant material may be arranged to withdraw moisture from the discharge passageway of the inhaler without isolating the discharge passage during inactivity.

Abstract: A reusable tip for minimally invasive surgical instruments can include an end effector, a two-part hub, and a yoke. The end effector can include one or more movable portions enabling the end effector to move between first (e.g., open) and second (e.g., closed) positions via manipulation of the yoke within the hub. The hub can include a proximal hub and a distal hub coupled together. The end effector can be coupled to the distal hub, which can be made of a metal to provide high strength and secure shape to the distal hub. The proximal hub can be made of an autoclavable insulation material capable of maintaining a removable coupling with a control shaft. The proximal hub can be made of polyetheretherketone (PEEK).

Abstract: Multi-segment manipulator arms are provided that exhibit improved performance in space applications, include reduced weight, reduced cost, reduced size, reduced rotational inertia, reduced vibration, improved heat dissipation characteristics, and increased reliability and on-station reparability. These manipulator arms transmit torque from a single motor at the base of the arm to each of the inter-segment joints via serial belts, rotationally linked via pulleys that are coaxial with the inter-segment joints. Brake(s) at each joint allow all but a selected joint to be fixed, allowing motor torque to be transmitted to the un-fixed joint, applying torque and/or rotation to the un-fixed joint. Placing the motor at the base facilitates heat management, reduces overall weight, and reduces total rotational inertia and weight of the arm segments.

Abstract: A method includes receiving a voice request to generate synthesized voiceover speech for a target advertisement having one or more advertising campaign attributes. The method also includes generating, based on the one or more advertising campaign attributes, a voiceover script that includes a sequence of text for the synthesized voiceover speech. The method also includes generating, using a text-to-speech (TTS) system, the synthesized voiceover speech. The TTS system is configured to receive, as input, the sequence of text for the voiceover script and generate, as output, the synthesized voiceover speech. Here, the synthesized voiceover speech has speech characteristics specified by a target TTS vertical. The method also includes overlaying the synthesized voiceover speech on the target advertisement.

Abstract: Systems and methods for isolating and/or desiccating a portion of a drug delivery tract of a drug delivery apparatus to reduce water vapor content therein are provided. For example, there is provided a metered dose inhaler for delivering aerosolized medicament or other matter to a user. The aerosolized medicament or other matter may be discharged from a discharge passageway within the inhaler into an inhalation passageway for inhalation by a user, and the inhaler may comprise a seal member operative to selectively isolate the discharge passageway from the inhalation passageway and external environment during inactivity. The inhaler may further comprise a desiccant material arranged to withdraw moisture from the isolated discharge passageway. In other instances, desiccant material may be arranged to withdraw moisture from the discharge passageway of the inhaler without isolating the discharge passage during inactivity.

Abstract: Systems and methods for isolating and/or desiccating a portion of a drug delivery tract of a drug delivery apparatus to reduce water vapor content therein are provided. For example, there is provided a metered dose inhaler for delivering aerosolized medicament or other matter to a user. The aerosolized medicament or other matter may be discharged from a discharge passageway within the inhaler into an inhalation passageway for inhalation by a user, and the inhaler may comprise a seal member operative to selectively isolate the discharge passageway from the inhalation passageway and external environment during inactivity. The inhaler may further comprise a desiccant material arranged to withdraw moisture from the isolated discharge passageway. In other instances, desiccant material may be arranged to withdraw moisture from the discharge passageway of the inhaler without isolating the discharge passage during inactivity.

Abstract: Systems and methods for isolating and/or desiccating a portion of a drug delivery tract of a drug delivery apparatus to reduce water vapor content therein are provided. For example, there is provided a metered dose inhaler for delivering aerosolized medicament or other matter to a user. The aerosolized medicament or other matter may be discharged from a discharge passageway within the inhaler into an inhalation passageway for inhalation by a user, and the inhaler may comprise a seal member operative to selectively isolate the discharge passageway from the inhalation passageway and external environment during inactivity. The inhaler may further comprise a desiccant material arranged to withdraw moisture from the isolated discharge passageway. In other instances, desiccant material may be arranged to withdraw moisture from the discharge passageway of the inhaler without isolating the discharge passage during inactivity.

Abstract: A method of treating or preventing periodontal disease in a subject comprises administering to the subject an inhibitor of ecto-nucleotide pyrophosphate/phosphodiesterase-I (ENPP1). An ecto-nucleotide pyrophosphate/phosphodiesterase-I (ENPP1) inhibitor and pharmaceutical compositions for use in treatment or prevention of periodontal disease or for increasing cementum formation are also disclosed.

Abstract: A reusable tip for minimally invasive surgical instruments can include an end effector, a two-part hub, and a yoke. The end effector can include one or more movable portions enabling the end effector to move between first (e.g., open) and second (e.g., closed) positions via manipulation of the yoke within the hub. The hub can include a proximal hub and a distal hub coupled together. The end effector can be coupled to the distal hub, which can be made of a metal to provide high strength and secure shape to the distal hub. The proximal hub can be made of an autoclavable insulation material capable of maintaining a removable coupling with a control shaft. The proximal hub can be made of polyetheretherketone (PEEK).

Abstract: The present disclosure provides systems and methods that generate a summary storyboard from a plurality of image frames. An example computer-implemented method can include inputting a plurality of image frames into a machine-learned model and receiving as an output of the machine-learned model, object data that describes the respective locations of a plurality of objects recognized in the plurality of image frames. The method can include generating a plurality of image crops that respectively include the plurality of objects and arranging two or more of the plurality of image crops to generate a storyboard.

Abstract: Systems and methods are provided to enhance the driving performance of a leanable vehicle such as a motorcycle. The system includes a leanable vehicle interface to receive input from a driver (e.g., a human or a robotic driver) and a sensor interface to receive inputs from sensors on the leanable vehicle. The system also includes a computing module to use the sensor data in combination with data from the leanable vehicle interface to calculate the driver behavior to produce a future desired performance, based on a specified aggressiveness, so that the performance of the leanable vehicle is optimized. The calculation may be done using a machine learning method, a rule based method, or both.

Abstract: A processing device executing a client of a distributed file system receives an initial file, wherein the distributed file system comprises a plurality of nodes, each of the plurality of nodes comprising a local file system that interfaces with the distributed file system. The processing device causes the plurality of nodes to generate file entries of the initial file. The processing device divides the initial file into a plurality of portions, each of the plurality of portions having initial offsets within the initial file. The processing device assigns subsets of the plurality of portions to the plurality of nodes, wherein each of the plurality of nodes is assigned a different subset. The processing device causes the plurality of nodes to write the portions of the assigned subsets at modified offsets within the file entries, wherein the modified offsets cause the portions of the assigned subsets to be contiguous.

Abstract: Derivatives of dillapiol, sesamol and related monolignans having the following general formula: These compounds have synergistic properties, inhibit cytochrome P450 enzymes such as human CYP3A4, and can be used as pesticide synergists or pharmaco-enhancers. Accordingly, methods for increasing the efficacy and/or bioavailability of a pharmaceutically active agent and for increasing the potency of a pesticide are described, as are synergistic pesticidal and pharmaceutical compositions.

Abstract: A processing device executing a client of a distributed file system receives an initial file, wherein the distributed file system comprises a plurality of nodes, each of the plurality of nodes comprising a local file system that interfaces with the distributed file system. The processing device causes the plurality of nodes to generate file entries of the initial file. The processing device divides the initial file into a plurality of portions, each of the plurality of portions having initial offsets within the initial file. The processing device assigns subsets of the plurality of portions to the plurality of nodes, wherein each of the plurality of nodes is assigned a different subset. The processing device causes the plurality of nodes to write the portions of the assigned subsets at modified offsets within the file entries, wherein the modified offsets cause the portions of the assigned subsets to be contiguous.

Abstract: An electronic billboard comprises at least one processor, at least one computer-readable tangible storage device, and program instructions stored on the at least one storage device for execution by the at least one processor. The program instructions comprise first program instructions configured to receive media content comprising text and at least one image. The program instructions further comprise second program instructions configured to separate the text and the at least one image. The program instructions further comprise third program instructions configured to cause the electronic billboard to display the text on a first predetermined portion of the electronic billboard. The program instructions further comprise fourth program instructions configured to cause the electronic billboard to display the image on a second predetermined portion of the electronic billboard.