Abstract: There is provided a method of concentrating functional biological components within a liquid suspension, the method comprising: providing a system comprising an ultrafiltration/concentration unit (UCU), the UCU comprising a first chamber for receiving therein the liquid suspension. a second chamber for receiving therein the filtrate, and a filter disposed in a fluid path therebetween. the filter comprising pores sizes so as to prevent passage therethrough of the biological components: introducing the liquid suspension into the first chamber: maintaining a pressure in the first chamber being no greater than approximately 2 bar; maintaining a pressure in the second chamber being lower than that of the first chamber: and harvesting the concentrated biological components: wherein a retentate is obtained in which the concentration of the biological components therewithin is increased. relative to the liquid suspension. by a factor of at least fifty.

Abstract: Provided herein are stem-cell based therapies for the treatment of neurodegenerative diseases and CNS disorder such as Huntington's disease. The therapy improved motor deficits and rescued synaptic alterations. The cells were shown to be electrophysiologically active and that they improved motor and late-stage cognitive impairment.

Abstract: This disclosure relates to populations and compositions of purified cell-derived vesicles and uses thereof. One aspect of the disclosure relates to methods for purifying the cell-derived vesicles.

Abstract: This disclosure relates to populations and compositions of purified cell-derived vesicles and uses thereof. One aspect of the disclosure relates to methods for purifying the cell-derived vesicles.