Patents by Inventor Brian G HASHIGUCHI
Brian G HASHIGUCHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11814348Abstract: Provided is an oxidizing composition, in which a liquid medium is substantially inert in the presence of an oxidizing electrophile contained in the liquid medium. The composition comprises (a) an oxidizing electrophile comprising a main group element in oxidized form and at least one conjugate anion of an oxygen acid; (b) a non-oxidizable liquid selected from a fluorinated hydrocarbon, a sulfone, a deactivated arene, a deactivated aliphatic, a deactivated heteroarene, a deactivated heteroaliphatic, and a combination thereof; and (c) optionally one or more salt additives. Further provided are a method of using the oxidizing composition to oxidize a substrate and a method of generating and/or regenerating an oxidizing electrophile comprising a main group element.Type: GrantFiled: May 25, 2018Date of Patent: November 14, 2023Assignees: University of Florida Research Foundation, Incorporated, Hyconix, Inc.Inventors: Roy A. Periana, Brian G. Hashiguchi, Michael M. Konnick
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Patent number: 11396492Abstract: Provided is a process for converting a hydrocarbon comprising at least one C—H bond to a nitrogen-functionalized product. The process comprises contacting a hydrocarbon and (i) an oxidizing electrophile comprising (a) a main group element or transition metal in oxidized form and (b) at least one nitrogen-containing ligand, or (ii) an oxidant and a reduced form of an oxidizing electrophile comprising (a) a main group element or transition metal and (b) at least one nitrogen-containing ligand, in a solvent to provide the nitrogen-functionalized product and an electrophile reduction product. Further provided is an oxidizing composition comprising the oxidizing electrophile with at least one nitrogen-containing ligand and a non-oxidizable liquid.Type: GrantFiled: November 30, 2018Date of Patent: July 26, 2022Assignees: University of Florida Research Foundation, Incorporated, Hyconix, Inc.Inventors: Roy A. Periana, Brian G. Hashiguchi, Sae Hume Park, Niles Jensen Gunsalus
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Patent number: 11078136Abstract: Provided is a process for converting an alkane to an alkene. The process comprises (a) contacting the alkane and either (i) an oxidizing electrophile comprising a main group element in oxidized form, or (ii) an oxidant and a reduced form of the oxidizing electrophile, in a liquid medium comprising an oxygen acid and optionally one or more additives selected from a non-oxidizable liquid, a salt additive, a Lewis acid, and water, to provide an oxidized intermediate and a reduced form of the oxidizing electrophile; (b) optionally separating the oxidized intermediate and the reduced form of the oxidizing electrophile; and (c) performing an elimination reaction on the oxidized intermediate to provide the alkene and the oxygen acid.Type: GrantFiled: May 25, 2018Date of Patent: August 3, 2021Assignees: The Scripps Research Institute, Hyconix, Inc.Inventors: Roy A. Periana, Brian G. Hashiguchi, Michael M. Konnick
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Publication number: 20210163503Abstract: Provided is an oxidizing composition, in which a liquid medium is substantially inert in the presence of an oxidizing electrophile contained in the liquid medium. The composition comprises (a) an oxidizing electrophile comprising a main group element in oxidized form and at least one conjugate anion of an oxygen acid; (b) a non-oxidizable liquid selected from a fluorinated hydrocarbon, a sulfone, a deactivated arene, a deactivated aliphatic, a deactivated heteroarene, a deactivated heteroaliphatic, and a combination thereof; and (c) optionally one or more salt additives. Further provided are a method of using the oxidizing composition to oxidize a substrate and a method of generating and/or regenerating an oxidizing electrophile comprising a main group element.Type: ApplicationFiled: May 25, 2018Publication date: June 3, 2021Applicants: The Scripps Research Institute, Hyconix, Inc.Inventors: Roy A. PERIANA, Brian G. HASHIGUCHI, Michael M. KONNICK
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Patent number: 10858301Abstract: Provided is a process for oxidizing an alkene. The process comprises contacting an alkene, and either an oxidizing electrophile comprising a main group element in oxidized form or an oxidant and a reduced form of the oxidizing electrophile, in a liquid medium comprising an oxygen acid and optionally one or more additives selected from a non-oxidizable liquid, a salt additive, a Lewis acid, and water, to provide an oxygenate and a reduced form of the oxidizing electrophile. The process optionally further comprises separating the oxygenate and the reduced form of the oxidizing electrophile. The oxygenate can be further hydrolyzed to form an alcohol, diol, or polyol.Type: GrantFiled: May 25, 2018Date of Patent: December 8, 2020Assignees: The Scripps Research Institute, Hyconix, Inc.Inventors: Roy A. Periana, Brian G. Hashiguchi, Michael M. Konnick
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Publication number: 20200377448Abstract: Provided is a process for converting a hydrocarbon comprising at least one C—H bond to a nitrogen-functionalized product. The process comprises contacting a hydrocarbon and (i) an oxidizing electrophile comprising (a) a main group element or transition metal in oxidized form and (b) at least one nitrogen-containing ligand, or (ii) an oxidant and a reduced form of an oxidizing electrophile comprising (a) a main group element or transition metal and (b) at least one nitrogen-containing ligand, in a solvent to provide the nitrogen-functionalized product and an electrophile reduction product. Further provided is an oxidizing composition comprising the oxidizing electrophile with at least one nitrogen-containing ligand and a non-oxidizable liquid.Type: ApplicationFiled: November 30, 2018Publication date: December 3, 2020Applicants: The Scripps Research Institute, Hyconix, Inc.Inventors: Roy A. PERIANA, Brian G. HASHIGUCHI, Sae Hume PARK, Niles Jensen GUNSALUS
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Patent number: 10745340Abstract: The invention provides processes and materials for the efficient and cost-effective functionalization of alkanes, such as methane from natural gas, to provide esters, alcohols, and other compounds. The method can be used to produce liquid fuels such as methanol from a natural gas methane-containing feedstock. The soft oxidizing electrophile, a compound of a main group, post-transitional element such as Tl, Pb, Bi, and I, that reacts to activate the alkane C—H bond can be regenerated using inexpensive regenerants such as hydrogen peroxide, oxygen, halogens, nitric acid, etc. Main group compounds useful for carrying out this reaction includes haloacetate salts of metals having a pair of available oxidation states, such as Tl, Pb, Bi, and I.Type: GrantFiled: February 25, 2014Date of Patent: August 18, 2020Assignee: The Scripps Research InstituteInventors: Roy A Periana, Brian G Hashiguchi, Michael M Konnick, Steven M Bischof
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Publication number: 20200095183Abstract: Provided is a process for oxidizing an alkene. The process comprises contacting an alkene, and either an oxidizing electrophile comprising a main group element in oxidized form or an oxidant and a reduced form of the oxidizing electrophile, in a liquid medium comprising an oxygen acid and optionally one or more additives selected from a non-oxidizable liquid, a salt additive, a Lewis acid, and water, to provide an oxygenate and a reduced form of the oxidizing electrophile. The process optionally further comprises separating the oxygenate and the reduced form of the oxidizing electrophile. The oxygenate can be further hydrolyzed to form an alcohol, diol, or polyol.Type: ApplicationFiled: May 25, 2018Publication date: March 26, 2020Applicants: The Scripps Research Institute, Hyconix, Inc.Inventors: Roy A. PERIANA, Brian G. HASHIGUCHI, Michael M. KONNICK
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Publication number: 20200095179Abstract: Provided is a process for converting an alkane to an alkene. The process comprises (a) contacting the alkane and either (i) an oxidizing electrophile comprising a main group element in oxidized form, or (ii) an oxidant and a reduced form of the oxidizing electrophile, in a liquid medium comprising an oxygen acid and optionally one or more additives selected from a non-oxidizable liquid, a salt additive, a Lewis acid, and water, to provide an oxidized intermediate and a reduced form of the oxidizing electrophile; (b) optionally separating the oxidized intermediate and the reduced form of the oxidizing electrophile; and (c) performing an elimination reaction on the oxidized intermediate to provide the alkene and the oxygen acid.Type: ApplicationFiled: May 25, 2018Publication date: March 26, 2020Applicants: The Scripps Research Institute, Hyconix, Inc.Inventors: Roy A. PERIANA, Brian G. HASHIGUCHI, Michael M. KONNICK
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Patent number: 10011547Abstract: Provided are methods and materials for the functionalization of a heteroalkane or arene using an oxidizing electrophile as a stoichiometric agent or catalyst. The reaction involves the replacement of a hydrogen atom on an sp3-hybridized carbon atom of the heteroalkane or of a hydrogen atom on an sp2-hybridized carbon atom of the arene. A main group element organometallic intermediate is formed that undergoes further conversion to a functionalized heteroalkane or arene.Type: GrantFiled: August 25, 2015Date of Patent: July 3, 2018Assignee: The Scripps Research InstituteInventors: Roy A. Periana, Michael M. Konnick, Brian G. Hashiguchi
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Publication number: 20170275222Abstract: Provided are methods and materials for the functionalization of a heteroalkane or arene using an oxidizing electrophile as a stoichiometric agent or catalyst. The reaction involves the replacement of a hydrogen atom on an sp3-hybridized carbon atom of the heteroalkane or of a hydrogen atom on an sp2-hybridized carbon atom of the arene. A main group element organometallic intermediate is formed that undergoes further conversion to a functionalized heteroalkane or arene.Type: ApplicationFiled: August 25, 2015Publication date: September 28, 2017Applicant: The Scripps Research InstituteInventors: Roy A. PERIANA, Michael M. KONNICK, Brian G. HASHIGUCHI
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Patent number: 9505714Abstract: The invention provides processes and materials for the efficient and costeffective functionalization of alkanes and heteroalkanes, comprising contacting the alkane or heteroalkane and a soft oxidizing electrophile comprising Se(VI) or Te(VI), in an acidic medium, optionally further comprising an aprotic medium, which can be carried out at a temperature of less than 300 C. Isolation of the alkylselenium or alkyltellurium intermediate allows the subsequent conversion to products not necessarily compatible with the initial reaction conditions, such as amines, stannanes, organosulfur compounds, acyls, halocarbons, and olefins.Type: GrantFiled: August 6, 2014Date of Patent: November 29, 2016Assignee: The Scripps Research InstituteInventors: Roy A. Periana, Michael M. Konnick, Brian G. Hashiguchi
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Publication number: 20160176812Abstract: The invention provides processes and materials for the efficient and costeffective functionalization of alkanes and heteroalkanes, comprising contacting the alkane or heteroalkane and a soft oxidizing electrophile comprising Se(VI) or Te(VI), in an acidic medium, optionally further comprising an aprotic medium, which can be carried out at a temperature of less than 300 C. Isolation of the alkylselenium or alkyltellurium intermediate allows the subsequent conversion to products not necessarily compatible with the initial reaction conditions, such as amines, stannanes, organosulfur compounds, acyls, halocarbons, and olefins.Type: ApplicationFiled: August 6, 2014Publication date: June 23, 2016Applicant: The Scripps Research InstituteInventors: Roy A. PERIANA, Michael M. KONNICK, Brian G. HASHIGUCHI
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Publication number: 20160002139Abstract: The invention provides processes and materials for the efficient and cost-effective functionalization of alkanes, such as methane from natural gas, to provide esters, alcohols, and other compounds. The method can be used to produce liquid fuels such as methanol from a natural gas methane-containing feedstock. The soft oxidizing electrophile, a compound of a main group, post-transitional element such as Tl, Pb, Bi, and I, that reacts to activate the alkane C—H bond can be regenerated using inexpensive regenerants such as hydrogen peroxide, oxygen, halogens, nitric acid, etc. Main group compounds useful for carrying out this reaction includes haloacetate salts of metals having a pair of available oxidation states, such as Tl, Pb, Bi, and I.Type: ApplicationFiled: February 25, 2014Publication date: January 7, 2016Applicant: The Scripps Research InstituteInventors: Roy A PERIANA, Brian G HASHIGUCHI, Michael M KONNICK, Steven M BISCHOF