Abstract: The invention describes transdermal vaccines which contain ultrasound responsive particles comprising a polypeptide shell. The surface of the particle has one or more indentations which are generally able to entrap a gas bubble. The particles are capable of generating inertial cavitation on exposure to ultrasound. The particles can be delivered transdermally, and can comprise antigen protein and/or adjuvant within the particle structure. The particles are therefore useful in methods of vaccination using transdermal delivery routes.

Abstract: Systems, apparatuses, and methods are described for providing audio assistance during trick play. Users, for example, visually-impaired users, may enable audio assistance features for trick play operations and customize audio assistance settings. The audio assistance may comprise outputting one or more audio cues during trick play. The audio cues may be associated with one or more types of scenes may indicate the progress of a trick play content item. The audio cues may also indicate automatic skipping of an objectionable scene or commercial and the output of a next scene.

Abstract: A method of dispensing a therapeutic fluid from a line includes providing an inlet line connectable to an upstream fluid source. The inlet line is in downstream fluid communication with a pumping chamber. The pumping chamber has a pump outlet. The method also includes actuating a force application assembly so as to restrict retrograde flow of fluid through the inlet while pressurizing the pumping chamber to urge flow through the pump outlet. A corresponding system employs the method.

Abstract: A method of dispensing a therapeutic fluid from a line includes providing an inlet line connectable to an upstream fluid source. The inlet line is in downstream fluid communication with a pumping chamber. The pumping chamber has a pump outlet. The method also includes actuating a force application assembly so as to restrict retrograde flow of fluid through the inlet while pressurizing the pumping chamber to urge flow through the pump outlet. A corresponding system employs the method.

Abstract: An occlusion device with particular utility in occlusion of left atrial appendages is described. The occlusion device embodiments utilize an inflatable balloon or expandable element used to occlude the treatment site.

Abstract: Systems, apparatuses, and methods are described for providing audio assistance during trick play. Users, for example, visually-impaired users, may enable audio assistance features for trick play operations and customize audio assistance settings. The audio assistance may comprise outputting one or more audio cues during trick play. The audio cues may be associated with one or more types of scenes may indicate the progress of a trick play content item. The audio cues may also indicate automatic skipping of an objectionable scene or commercial and the output of a next scene.

Abstract: A computer-implemented method may be used for semantic navigation of content. The method may include determining a first content complexity level for a user, and presenting a first content to a user device operated by the user. The first content may be presented at the first content complexity level of the user. Additionally, the method may include receiving a navigation command from the user on a portion of the first content via the user device; and determining a second content at a second content complexity level based on the navigation command. The second content may convey the same information as the first content. Additionally, the method may include replacing the first content with the second content on the user device. The second content may be presented at the second content complexity level, and the second content complexity level may be different than the first content complexity level.

Abstract: A covering retention assembly including first and second clips. Each clip includes a base plate and a top plate. The base plate extends from a rear end to a forward end with at least one base plate tooth extending from an inner surface thereof proximate the forward end. The top plate extends from a rear end to a forward end with at least one top plate tooth extending from an inner surface thereof proximate the forward end. A hinge assembly interconnects the base plate and top plate such that the forward end of the top plate is biased toward the forward end of the base plate and wherein one of the teeth contacts the inner surface of the other plate and each tooth of the base plate and is laterally and longitudinally spaced from each tooth of the top plate. A strap extends between first and second free ends, with the first free end connected with the first clip and the second free end connected with the second clip.

Abstract: An occlusion device with particular utility in occlusion of left atrial appendages is described. The occlusion device embodiments utilize an inflatable balloon or expandable element used to occlude the treatment site.

Abstract: A method for making a fluid delivery device including a reusable portion and a disposable portion. The disposable portion is adapted to be secured to a user and includes a conduit fluidly connecting a reservoir containing a fluid and a moveable pumping member. The moveable pumping member can expand an expandable structure with the fluid. The reusable portion is selectively engageable to the disposable portion and contains a drive device for engaging the moveable pumping member of the disposable portion. The drive device has a rotatable pumping actuation member with a plurality of projections for engaging the moveable pumping member and thereby moving the fluid to expand the expandable structure.

Abstract: Systems, apparatuses, and methods are described for providing audio assistance during trick play. Users, for example, visually-impaired users, may enable audio assistance features for trick play operations and customize audio assistance settings. The audio assistance may comprise outputting one or more audio cues during trick play. The audio cues may be associated with one or more types of scenes may indicate the progress of a trick play content item. The audio cues may also indicate automatic skipping of an objectionable scene or commercial and the output of a next scene.

Abstract: A water vapor distillation system.

Abstract: A method of dispensing a therapeutic fluid from a line includes providing an inlet line connectable to an upstream fluid source. The inlet line is in downstream fluid communication with a pumping chamber. The pumping chamber has a pump outlet. The method also includes actuating a force application assembly so as to restrict retrograde flow of fluid through the inlet while pressurizing the pumping chamber to urge flow through the pump outlet. A corresponding system employs the method.

Abstract: A wearable infusion pump assembly includes a reservoir for receiving an infusible fluid, and an external infusion set configured to deliver the infusible fluid to a user. A fluid delivery system is configured to deliver the infusible fluid from the reservoir to the external infusion set. The fluid delivery system includes a volume sensor assembly, and a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the volume sensor assembly. The volume sensor assembly is configured to determine the volume of at least a portion of the quantity of fluid. The fluid delivery system further includes a first valve assembly configured to selectively isolate the pump assembly from the reservoir, and a second valve assembly configured to selectively isolate the volume sensor assembly from the external infusion set.

Abstract: Some aspects of the disclosure relate to a system and methods for creating a viewing impression that can comprise selecting a video frame from a content item based on interest or value in the video frame. Another version of the content, such as a trick file, can be created by inserting one or more copies of the video frame, for example, adjacent to one another.

Abstract: A wearable infusion pump assembly includes a reusable housing assembly, and a disposable housing assembly including a reservoir for receiving an infusible fluid. The wearable infusion pump assembly also includes a releasable engagement assembly configured to allow the reusable housing assembly to releasably engage the disposable housing assembly. A switch assembly of the wearable infusion pump assembly is configured to effectuate a functionality of the infusion pump assembly.

Abstract: A water vapor distillation system.

Abstract: Provided are amorphous and at least partially crystalline polyetherimide compositions having a comparatively narrow particle size distribution and are particularly suited for additive manufacturing processes. The compositions comprise a population of polyetherimide particulates are characterized as having a zero-shear viscosity sufficiently low so as to achieve a coalescence of at least 0.5, and preferably of about 1.0, as characterized by the Frenkel model at a temperature less than 450° C.

Abstract: Systems, apparatuses, and methods are described for providing audio assistance during trick play. Users, for example, visually-impaired users, may enable audio assistance features for trick play operations and customize audio assistance settings. The audio assistance may comprise outputting one or more audio cues during trick play. The audio cues may be associated with one or more types of scenes may indicate the progress of a trick play content item. The audio cues may also indicate automatic skipping of an objectionable scene or commercial and the output of a next scene.

Abstract: A water vapor distillation system.