Patents by Inventor Brian Grella

Brian Grella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
    Publication number: 20070219235
    Abstract: The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.
    Type: Application
    Filed: February 9, 2007
    Publication date: September 20, 2007
    Inventors: Adnan Mjalli, Brian Grella, Govindan Subramanian, Murty Arimilli, Ramesh Gopalaswamy, Robert Andrews, Stephen Davis, Xiaochuan Guo, Jeff Zhu
  • Indoles as NAALADase inhibitors
    Patent number: 7148250
    Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALAdase levels are altered, effecting neuronal activity, effecting TGF-? activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: December 12, 2006
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Takashi Tsukamoto, Brian Grella, Pavel Majer
  • Indoles as naaladase inhibitors
    Publication number: 20050080128
    Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALAdase levels are altered, effecting neuronal activity, effecting TGF-? activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
    Type: Application
    Filed: December 19, 2002
    Publication date: April 14, 2005
    Inventors: Takashi Tsukamoto, Brian Grella, Pavel Majer