Patents by Inventor Brian Grimberg

Brian Grimberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12318180
    Abstract: A system is described herein that can be used to perform magneto-optical detection of a disease component in a test sample using magnetic nanoparticles. A concentration of magnetic nanoparticles and a concentration of bindable agents can be administered to the test sample. The magnetic nanoparticles can be configured to attach to the bindable agents. A light beam can be transmitted through the test sample to a light detector. A magnetic field gradient can be established through the test sample. If the transmitted light beam under the magnetic field gradient exhibits a variable intensity change during a time period, the disease component can be determined to exist in the test sample.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: June 3, 2025
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Tanvir Baig, Robert Deissler, Brian Grimberg, Robert Brown, Michael Martens
  • Publication number: 20210109094
    Abstract: Disease components can be detected in a fluid using magnetic particles and microfluidics. Magnetic particles are combined with a sample in a fluid. The sample may include disease components. The magnetic particles can be configured to tag any disease components within the sample. The fluid can be forced into a microchamber with two microcompartments. In the first microcompartment, the fluid can be exposed to a magnetic field and/or magnetic field gradient. The tagged disease component can be trapped by the magnetic field and/or magnetic field gradient due to the magnetic particles, allowing nonmagnetic components of the fluid to be washed away while the tagged disease components remain trapped by the magnetic field and/or magnetic field gradient. Then, the disease components can be forced into a more narrow second microcompartment and detected using optical instruments.
    Type: Application
    Filed: October 12, 2020
    Publication date: April 15, 2021
    Inventors: Robert Deissler, Brian Grimberg, Umut Gurkan, Susann Brady-Kalnay, Robert Brown, Yuncheng Man, Ran An
  • Publication number: 20210068697
    Abstract: A system is described herein that can be used to perform magneto-optical detection of a disease component in a test sample using magnetic nanoparticles. A concentration of magnetic nanoparticles and a concentration of bindable agents can be administered to the test sample. The magnetic nanoparticles can be configured to attach to the bindable agents. A light beam can be transmitted through the test sample to a light detector. A magnetic field gradient can be established through the test sample. If the transmitted light beam under the magnetic field gradient exhibits a variable intensity change during a time period, the disease component can be determined to exist in the test sample.
    Type: Application
    Filed: October 27, 2020
    Publication date: March 11, 2021
    Inventors: Tanvir Baig, Robert Deissler, Brian Grimberg, Robert Brown, Michael Martens
  • Publication number: 20200085340
    Abstract: A system is described herein that can be used to perform magneto-optical detection of a disease component in a test sample using magnetic nanoparticles. A concentration of magnetic nanoparticles and a concentration of bindable agents can be administered to the test sample. The magnetic nanoparticles can be configured to attach to the bindable agents. A light beam can be transmitted through the test sample to a light detector. A magnetic field gradient can be established through the test sample. If the transmitted light beam under the magnetic field gradient exhibits a variable intensity change during a time period, the disease component can be determined to exist in the test sample.
    Type: Application
    Filed: September 18, 2018
    Publication date: March 19, 2020
    Inventors: Tanvir Baig, Robert Deissler, Brian Grimberg, Robert Brown, Michael Martens