Patents by Inventor Brian GRINDEL

Brian GRINDEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PD-L1 binding peptides
    Patent number: 12643935
    Abstract: The disclosure provides synthetic peptides that selectively bind to the PD-L1 protein on the surface of cells expressing PD-L1. The PD-L1 binding peptide may comprises the amino acid sequence MX1X2X3X4DHX5LNKFX6IX7HXsX9X10X11X12X13 (SEQ ID NO: 177) or MXIF?XXIXXX?WXLXXA (SEQ ID NO: 1). Peptides of the disclosure may be functionalized using one or more diagnostic agents to aid in various detection modalities or with a cytotoxic agent to treat various disease states such as cancer. Also provided are compositions that include the PD-L1 binding peptides or functionalized PD-L1 binding peptides.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: June 2, 2026
    Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Terry Takahashi, Richard W. Roberts, Golnaz Kamalinia, Justin Ong, Brian Grindel, Brian Engel, Steven Millward
  • PD-L1 BINDING PEPTIDES
    Publication number: 20230174616
    Abstract: The disclosure provides synthetic peptides that selectively bind to the PD-L1 protein on the surface of cells expressing PD-L1. The PD-L1 binding peptide may comprises the amino acid sequence MX1X2X3X4DHX5LNKFX6IX7HX8X9X10X11X12X13 (SEQ ID NO: 177) or MXIF?XXIXXX?WXLXXA (SEQ ID NO: 1). Peptides of the disclosure may be functionalized using one or more diagnostic agents to aid in various detection modalities or with a cytotoxic agent to treat various disease states such as cancer. Also provided are compositions that include the PD-L1 binding peptides or functionalized PD-L1 binding peptides.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 8, 2023
    Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Terry TAKAHASHI, Richard W. ROBERTS, Golnaz KAMALINIA, Justin ONG, Brian GRINDEL, Brian ENGEL, Steven MILLWARD