Patents by Inventor Brian H. Johnstone

Brian H. Johnstone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Warming cryopreserved bone
    Patent number: 11896005
    Abstract: The present disclosure relates to, at least, a vacuum-assisted method for infiltrating cadaver bone with a cryoprotectant and a method for rapidly warming the cryopreserved cadaver bone for bone marrow processing.
    Type: Grant
    Filed: January 17, 2023
    Date of Patent: February 13, 2024
    Assignee: Ossium Health, Inc.
    Inventors: Erik J. Woods, Brian H. Johnstone
  • Methods of cell therapies
    Patent number: 11786558
    Abstract: Described herein are methods of cell therapies. Also described herein are methods of generating donor derived T cells in an organ transplant recipient, by administering bone marrow stem cells to the organ transplant recipient about 1 to about 30 days after the organ transplant recipient receives one or more organ transplants.
    Type: Grant
    Filed: March 16, 2022
    Date of Patent: October 17, 2023
    Assignee: Ossium Health, Inc.
    Inventors: Erik J. Woods, Brian H. Johnstone, Dongsheng Gu, Aubrey Marie Sherry, Kelsey Gwen Musall, Megan Sykes, Tomoaki Kato, Jianing Fu
  • Systems and methods for extraction and cryopreservation of bone marrow
    Patent number: 11744243
    Abstract: Methods, systems, and compositions are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation, and for obtaining desired cells from cryopreserved and fresh bone marrow.
    Type: Grant
    Filed: March 1, 2022
    Date of Patent: September 5, 2023
    Assignee: OSSIUM HEALTH, INC.
    Inventors: Erik J. Woods, Brian H. Johnstone, Dongsheng Gu, Aubrey Marie Sherry, Kelsey Gwen Musall
  • PERMEATION OF WHOLE VERTEBRAL BODIES WITH A CRYOPROTECTANT USING VACUUM ASSISTED DIFFUSION
    Publication number: 20230232820
    Abstract: The present disclosure relates to, at least, a vacuum-assisted method for infiltrating cadaver bone with a cryoprotectant and a method for rapidly warming the cryopreserved cadaver bone for bone marrow processing.
    Type: Application
    Filed: January 17, 2023
    Publication date: July 27, 2023
    Inventors: Erik J. WOODS, Brian H. JOHNSTONE
  • System and method for extraction and cryopreservation of bone marrow
    Patent number: 11702637
    Abstract: Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: July 18, 2023
    Assignee: Ossium Health, Inc.
    Inventors: Erik John Woods, Brian H. Johnstone, Dongsheng Gu, Aubrey Marie Sherry, Kelsey Gwen Musall, John R. Woods, James Hardin, Alan Hooks
  • System and method for extraction and cryopreservation of bone marrow
    Patent number: 11697799
    Abstract: Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: July 11, 2023
    Assignee: Ossium Health, Inc.
    Inventors: Erik John Woods, Brian H. Johnstone, Dongsheng Gu, Aubrey Marie Sherry, Kelsey Gwen Musall, John R. Woods, James Hardin, Alan Hooks
  • System and method for extraction and cryopreservation of bone marrow
    Patent number: 11447750
    Abstract: Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: September 20, 2022
    Assignee: Ossium Health, Inc.
    Inventors: Erik John Woods, Brian H. Johnstone, Dongsheng Gu, Aubrey Marie Sherry, Kelsey Gwen Musall, John R. Woods, James Hardin, Alan Hooks
  • METHODS OF CELL THERAPIES
    Publication number: 20220241342
    Abstract: Described herein are methods of cell therapies. Also described herein are methods of generating donor derived T cells in an organ transplant recipient, by administering bone marrow stem cells to the organ transplant recipient about 1 to about 30 days after the organ transplant recipient receives one or more organ transplants.
    Type: Application
    Filed: March 16, 2022
    Publication date: August 4, 2022
    Inventors: Erik J. Woods, Brian H. Johnstone, Dongsheng Gu, Aubrey Marie Sherry, Kelsey Gwen Musall, Megan Sykes, Tomoaki Kato
  • METHODS FOR STORAGE OF STEM CELLS
    Publication number: 20220195393
    Abstract: Described herein are methods and systems for preparing samples of stem cells for direct infusion. Some of the methods and systems described herein comprise hypothermic storage of the stem cells. The methods and systems described herein can supplement shipment of stem cells across long distances such that the stem cells are prepared for direct infusion upon receipt of the cells.
    Type: Application
    Filed: February 8, 2022
    Publication date: June 23, 2022
    Inventors: Erik J. WOODS, Hannah Marie MILLER, Brian H. JOHNSTONE
  • SYSTEMS AND METHODS FOR EXTRACTION AND CRYOPRESERVATION OF BONE MARROW
    Publication number: 20220183275
    Abstract: Methods, systems, and compositions are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation, and for obtaining desired cells from cryopreserved and fresh bone marrow
    Type: Application
    Filed: March 1, 2022
    Publication date: June 16, 2022
    Inventors: Erik J. WOODS, Brian H. JOHNSTONE, Dongsheng GU, Aubrey Marie SHERRY, Kelsey Gwen MUSALL
  • COMPOSITIONS AND METHODS FOR EXTRACTION OF MESENCHYMAL STEM CELLS
    Publication number: 20220186187
    Abstract: Compositions and methods for the extraction mesenchymal cells from deceased donor bone, and therapeutic applications thereof, along with combination therapeutic applications comprising mesenchymal cells from deceased donors and bone marrow derived from deceased donors are presented.
    Type: Application
    Filed: March 1, 2022
    Publication date: June 16, 2022
    Inventors: Erik J. WOODS, Brian H. JOHNSTONE, Dongsheng GU, Hannah Marie MILLER
  • PERFUSION SYSTEM FOR HARVESTING BONE MARROW
    Publication number: 20210317415
    Abstract: Provided herein are methods and systems for recovering bone marrow. The methods comprising perfusing a bone with a perfusion media and recovering the liberated bone marrow cells.
    Type: Application
    Filed: April 9, 2021
    Publication date: October 14, 2021
    Inventors: Erik J. WOODS, Brian H. JOHNSTONE
  • System and method for extraction and cryopreservation of bone marrow
    Patent number: 11104882
    Abstract: Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: August 31, 2021
    Assignee: Ossium Health, Inc.
    Inventors: Erik John Woods, Brian H. Johnstone, Dongsheng Gu, Aubrey Marie Sherry, Kelsey Gwen Musall, John R. Woods, James Hardin, Alan Hooks
  • System and method for extraction and cryopreservation of bone marrow
    Patent number: 11085024
    Abstract: Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: August 10, 2021
    Assignee: Ossium Health, Inc.
    Inventors: Erik John Woods, Brian H. Johnstone, Dongsheng Gu, Aubrey Marie Sherry, Kelsey Gwen Musall, John R. Woods, James Hardin, Alan Hooks
  • SYSTEM AND METHOD FOR EXTRACTION AND CRYOPRESERVATION OF BONE MARROW
    Publication number: 20210214688
    Abstract: Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.
    Type: Application
    Filed: March 11, 2021
    Publication date: July 15, 2021
    Inventors: Erik J. WOODS, Brian H. JOHNSTONE, Dongsheng GU, Aubrey Marie SHERRY, Kelsey Gwen MUSALL, John R. WOODS, James HARDIN, Alan HOOKS
  • System and method for extraction and cryopreservation of bone marrow
    Patent number: 10995318
    Abstract: Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: May 4, 2021
    Assignee: Ossium Health, Inc.
    Inventors: Erik John Woods, Brian H. Johnstone, Dongsheng Gu, Aubrey Marie Sherry, Kelsey Gwen Musall, John R. Woods, James Hardin, Alan Hooks
  • Cutting apparatus for bioprocessing bone
    Patent number: 10980547
    Abstract: A bone cutting assembly includes a manually actuated upper cutting element that carries a plurality of cutting blades configured to cut through frozen bone segments. A lower cutting element supports a bone segment to be cut and can include cutting blades aligned with the cutting blades of the upper cutting assembly. A pivoting linkage or a rack and pinion arrangement can be provided between the upper cutting element and a manually operated handle to provide sufficient mechanical advantage or leverage to allow an operator to manually cut through the bone.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: April 20, 2021
    Assignee: Ossium Health, Inc.
    Inventors: Erik J. Woods, Brian H. Johnstone, Joseph Ingalls
  • CUTTING APPARATUS FOR BIOPROCESSING BONE
    Publication number: 20210037810
    Abstract: A bone cutting assembly includes a manually actuated upper cutting element that carries a plurality of cutting blades configured to cut through frozen bone segments. A lower cutting element supports a bone segment to be cut and can include cutting blades aligned with the cutting blades of the upper cutting assembly. A pivoting linkage or a rack and pinion arrangement can be provided between the upper cutting element and a manually operated handle to provide sufficient mechanical advantage or leverage to allow an operator to manually cut through the bone.
    Type: Application
    Filed: October 23, 2020
    Publication date: February 11, 2021
    Inventors: Erik J. Woods, Brian H. JOHNSTONE, Joseph INGALLS
  • SYSTEM AND METHOD FOR EXTRACTION AND CRYOPRESERVATION OF BONE MARROW
    Publication number: 20200399608
    Abstract: Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.
    Type: Application
    Filed: September 4, 2020
    Publication date: December 24, 2020
    Inventors: Erik John WOODS, Brian H. JOHNSTONE, Dongsheng GU, Aubrey Marie SHERRY, Kelsey Gwen MUSALL, John R. WOODS, James HARDIN, Alan HOOKS
  • SYSTEM AND METHOD FOR EXTRACTION AND CRYOPRESERVATION OF BONE MARROW
    Publication number: 20200399604
    Abstract: Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.
    Type: Application
    Filed: September 4, 2020
    Publication date: December 24, 2020
    Inventors: Erik John WOODS, Brian H. JOHNSTONE, Dongsheng GU, Aubrey Marie SHERRY, Kelsey Gwen MUSALL, John R. WOODS, James HARDIN, Alan HOOKS