Abstract: Systems, methods, and computer-readable media, are disclosed in which a variety of data describing the condition of an object can be obtained and probabilistic likelihoods of causes and/or value of damages to the object can be calculated. In a variety of embodiments, data obtained from third-party systems can be utilized in these calculations. Any of a number of machine classifiers can be utilized to generate the probabilistic likelihoods and confidence metrics in the calculated liabilities. A variety of user interfaces for efficiently obtaining and visualizing the object, the surrounding geographic conditions, and/or the probabilistic likelihoods can further be utilized as appropriate. User interfaces can include a scene sketch tool application program interface and/or a liability tool user interface and various data sources can be used to dynamically generate diagrams of object damage and/or the environment in which the object was damaged.

Abstract: The invention described herein provides a solid dosage form administration system comprising: an oral solid dosage form containing an active ingredient; and a hand-held applicator; wherein the hand-held applicator is removably coupled to the dosage form. The system includes a reversible coupling structure permitting repeated engagement and disengagement of the dosage form component from the hand-held applicator component of the system. In one embodiment, the applicator is composed of a soft durometer flexible polymeric material. The invention can be used to administer various medicaments, and is especially useful in treatment of nicotine addiction.

Abstract: The present invention includes a disposal system for disposal of medicated oral dosage forms comprising: 1) a container having a top, a bottom, and a sidewall, the container having a plurality of apertures located thereon; 2) a uni-directional port for securing a medicated oral dosage form within the container wherein the uni-directional port allows the medicated oral dosage form to be easily inserted into the container, but prevents the medicated oral dosage form from being removed from the container such that the medicated oral dosage form is secured within the container; and 3) a fluid propulsion device and system, such as a dishwasher, for disposing of the medicated oral dosage form, wherein the fluid propulsion device causes or directs a fluid to penetrate the container through a single aperture or the plurality of apertures in the container, thus causing the fluid to dissolve and dispose of the medicated oral dosage form.

Abstract: The present invention relates to a system for identification for pharmaceutical products, and more particularly to a system for identification of an analgesic dosage unit. The invention relates directly to a system for providing direct safety at the point of use of a pharmaceutical product.

Abstract: The present invention is directed to oral solid dosage forms. The solid dosage forms are sugar-free, and comprise a pharmaceutical agent and a suitable pharmaceutically acceptable excipient. Preferably, the solid dosage forms of the present invention are bioequivalent to a sugar-containing solid dosage form. Bioequivalence is preferably obtained by incorporating an ionizing agent, more preferably in the form of a buffer system, into the solid dosage forms, in an amount sufficient to maintain a portion of the pharmaceutical agent, upon dissolution of said composition in saliva, in an ionized state.

Abstract: The present invention includes a disposal system for disposal of medicated oral dosage forms comprising: 1) a container having a top, a bottom, and a sidewall, the container having a plurality of apertures located thereon; 2) means for securing a medicated oral dosage form within the container wherein the means allows the medicated oral dosage form to be easily inserted into the container, but substantially prevents the medicated oral dosage form from being removed from the container such that the medicated oral dosage form is secured within the container; and 3) a fluid propulsion device and system, such as a dishwasher, for disposing of the medicated oral dosage form, wherein the fluid propulsion device causes or directs a fluid to penetrate the container through a single aperture or the plurality of apertures in the container, thus causing the fluid to dissolve and dispose of the medicated oral dosage form.

Abstract: An apparatus for the reusable interim storage of partially consumed medicated oral dosage forms and methods for employing such an apparatus in order to use medicated oral dosage forms in the safest possible manner. The apparatus of the present invention in its broadest terms comprises (1) a container sized to hold a medicated oral dosage form, (2) means for allowing a medicated oral dosage form easy access into the container but substantially preventing the medicated oral dosage form from passing out of the container, and (3) a child resistant means for allowing an adult to remove a medicated oral dosage form from within the container despite the one-way access means. The preferred embodiment comprises an opaque container having one opening, a child resistant closure with an aperture there through that extends over said opening, and a plastic slitted membrane covering said aperture.

Abstract: An apparatus for the reusable interim storage of partially consumed medicated oral dosage forms and methods for employing such an apparatus in order to use medicated oral dosage forms in the safest possible manner. The apparatus of the present invention in its broadest terms comprises (1) a container sized to hold a medicated oral dosage form, (2) means for allowing a medicated oral dosage form easy access into the container but substantially preventing the medicated oral dosage form from passing out of the container, and (3) a child resistant means for allowing an adult to remove a medicated oral dosage form from within the container despite the one-way access means. The preferred embodiment comprises an opaque container having one opening, a child resistant closure with an aperture there through that extends over said opening, and a plastic slitted membrane covering said aperture.

Abstract: An apparatus for the reusable interim storage of partially consumed medicated oral dosage forms and methods for employing such an apparatus in order to use medicated oral dosage forms in the safest possible manner. The apparatus of the present invention in its broadest terms comprises (1) a container sized to hold a medicated oral dosage form, (2) means for allowing a medicated oral dosage form easy access into the container but substantially preventing the medicated oral dosage form from passing out of the container, and (3) a child resistant means for allowing an adult to remove a medicated oral dosage form from within the container despite the one-way access means. The preferred embodiment comprises an opaque container having one opening, a child resistant closure with an aperture there through that extends over said opening, and a plastic slitted membrane covering said aperture.

Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to manufacturing techniques that enable therapeutic agents to be incorporated into nondissolvable drug containment matrixes which are capable of releasing the drug within a patient's mouth. An appliance or holder is preferably attached to the drug containment matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods.

Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored dissolvable matrix. An appliance or holder is preferably attached to the dissolvable matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods.

Abstract: The present invention relates to a selectively removable nicotine-containing dosage form for use in the transmucosal delivery of nicotine to a patient. More specifically, the present invention is directed to a nicotine-containing dosage-form comprising an attached holder member which may be used to manipulate the dosage form within the mouth of the patient as part of an effective smoking cessation program or in situations where smoking is undesirable or not permitted. Nicotine is released from a dosage form and absorbed through the intra-oral mucosal surfaces as the nicotine-containing matrix releases nicotine within the user's mouth. The user may selectively insert and remove the dosage form as desired to control the release of nicotine. In addition, the user may manipulate the dosage form by use of the holder means in such a manner to meet the user's psychological need or desire for ritualistic oral stimulation similar to cigarette smoking.

Abstract: The present invention is directed to methods and compositions for noninvasively administering drugs in a dose-to-effect manner to produce a cardiovascular or renal vascular activity. A cardiovascular or renal vascular drug, which is capable of absorption through mucosal tissues of the mouth, pharnyx, and esophagus is incorporated into a matrix which is in the form of a lollipop. A patient is put at ease when given the lollipop, and the drug rapidly enters the patient's bloodstream as the lollipop is sucked. When treating the patient, the physician can observe the patient's condition and remove the lollipop when it has had a desired effect on the patient. A lollipop into which a cardiovascular or renal vascular drug has been dispersed is particularly useful for achieving rapid vasodilating, calcium channel blocking, beta-blocking, seritonin receptor blocking, angina blocking, antihypertensive, and cardiac stimulating effects and for controlling urine output.

Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to manufacturing techniques that enable therapeutic agents to be incorporated into nondissolvable drug containment matrixes which are capable of releasing the drug within a patient's mouth. An appliance or holder is preferably attached to the drug containment matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods.

Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored dissolvable matrix. An appliance or holder is preferably attached to the dissolvable matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods.

Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored confectionary base and to compress or otherwise attach the solid confectionary mixture onto an appliance or holder.Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods. The present invention achieves these advantages by incorporating the drug into a compressed powder "candy" matrix.

Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored confectionary base and to compress or otherwise attach the solid confectionary mixture onto an appliance or holder. Employing the present invention, the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods. The present invention achieves these advantages by incorporating the drug into a compressed powder "candy " matrix.