Patents by Inventor Brian Heimbuch

Brian Heimbuch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIV integrase inhibitors
    Patent number: 6395743
    Abstract: Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Actinoplanes sp. MA7220 (ATCC 202188) is also disclosed, as well as processes for making compounds of the present invention employing the culture.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: May 28, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Brian Heimbuch, Sheo Singh, Deborah L. Zink, Magda Gagliardi, Olga Genilloud, Ana Teran
  • 11-hydroxysordarin and a process for producing it using actinomyces SSP
    Patent number: 6228622
    Abstract: 11-hydroxysordarin, biotransformation product of a fermentation with sordarin and Actinomyces spp., (Merck Culture Collection MA7235) ATCC No. 202103 is an antifungal agent. This compound may be useful in the treatment of diseases caused by fungal pathogens such as Candida albicans.
    Type: Grant
    Filed: October 26, 1999
    Date of Patent: May 8, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Michael G. Sturr, Michel M. Chartrain, Guy H. Harris, Jennifer Nielsen-Kahn, Brian Heimbuch
  • Conversion of indene to (1S)-amino-(2R)-indanol free of any steroisomer by combination of fermentation of Rhodococcus sp. ATCC 55805 and chemical steps
    Patent number: 5871981
    Abstract: A method for preparing (1S)-amino-(2R)-indandiol substantially free of its stereoisomers is presented. The method comprises culturing indene with Rhodococcus sp. ATCC 55805, recovering the indandiol and subjecting the indandiol to chiral specific crystallization, treatment with strong acid and reverse ion pair extraction.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: February 16, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Michel Chartrain, Barbara A. Jackey, Brian Heimbuch, Colleen S. Taylor
  • Conversion of indene to (1S)-amino-(2R)-indanol free of any stereoisomer, by combination of dioxygenase bioconversion and chemical steps
    Patent number: 5858737
    Abstract: A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of a strain of P. putida or Rhodococcus sp., followed by various chemical step(s), e.g., chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.
    Type: Grant
    Filed: August 14, 1996
    Date of Patent: January 12, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Barry C. Buckland, Neal C. Connors, Michel M. Chartrain, Francis P. Gailliot, Randolph L. Greasham, Barbara Jackey, Brian Heimbuch, Chanyong Lee, Roger C. Olewinski, Jr., F. Edward Roberts, Paul J. Reider, Thomas R. Verhoeven, Chris H. Senanayake
  • Streptomyces sp. MA 7074 (ATCC 55605) used for microbial synthesis of HIV protease inhibitors
    Patent number: 5612217
    Abstract: Biotransformation products of a fermentation with culture MA7074 are potent HIV protease inhibitors. These products are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: March 18, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Ali Shafiee, Shieh-Shung T. Chen, Byron H. Arison, Randall R. Miller, George M. Garrity, Brian Heimbuch
  • Microbial method
    Patent number: 5491077
    Abstract: The present invention provides a process for the stereoselective reduction of phenylalkyl ketones to their corresponding (S)-hydroxy compounds. The process utilizes the novel microorganism Microbacterium MB 5614 to effectuate the chiral reduction. The present invention also provides said novel Microbacterium, which has been deposited with the ATCC and assigned the accession number ATCC 55557.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: February 13, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Michel M. Chartrain, Shieh-Shung T. Chen, George M. Garrity, Brian Heimbuch, Christopher Roberge, Ali Shafiee