Abstract: In one embodiment, a device performs a detection stage of an automated instrumentation pipeline during which the device detects an application server type by examining a command line of a process of an application. The device performs, based on the application server type, an extraction stage of the automated instrumentation pipeline during which the device extracts application server attributes. The device performs, based on the application server attributes, a naming stage of the automated instrumentation pipeline during which the device forms a naming hierarchy for processes of the application. The detection stage, the extraction stage, and the naming stage of the automated instrumentation pipeline do not have access to a controlled space of the application. The device inserts, based in part on the naming hierarchy, arguments into command lines of processes of the application that cause the processes of the application to be instrumented at runtime.

Abstract: A technique relates to route planning. Points associated with a start location and a destination location are received. It is determined whether the points comprise one or more hard points, one or more soft points, or both. At least one obstruction to avoid is determined. A route is autonomously generated comprising the points and segments associated with the points, the segments comprising rhumb lines, great-circle arcs, or both. Responsive to the points comprising the one or more soft points, the at least one obstruction is avoided by permitting a distance associated with the one or more soft points to be reached and adding at least one free waypoint. Responsive to the points comprising the one or more hard points, the at least one obstruction is avoided by requiring the one or more hard points to be reached and adding the at least one free waypoint.

Abstract: Embodiments of the present disclosure are directed to a rotatable play device that comprises a central support post, a hub rotatably mounted to an upper end of the central support post, and an arm assembly attached to the hub and comprising a plurality of arms, a seat being suspended from the distal end of each of the plurality of arms. Rotation of the hub about the central support post causes the plurality of seats to rotate around the central support post in a substantially circular rotation path. Each of the seats may also be configured to move up and down by way of a spring assembly or a plurality of springs. Two or more seats may share the up-and-down movement in an alternating manner or each seat may be configured to have an independent up-and-down movement. In addition, each of the seats may optionally be configured to swing in substantial alignment with the circular rotation path and/or to swing outward due to centripetal forces created by the circular rotation path.

Abstract: A suture anchor comprises a tubular body having an axial bore therethrough and having one or more purchase enhancements on an exterior surface of the body adapted to enhance purchase of the body within a bone hole, such as threads. A lateral port passes through the body from the bore to the exterior surface and is formed of a slot entering the body from its proximal end. A length of suture for attaching soft tissue to bone passes down along the exterior surface over the one or more purchase enhancements, over a distal end of the body, up into the bore through and then back out of the bore and up along the exterior surface over the one or more purchase enhancements.

Abstract: A technique relates to autonomous obstacle avoidance. A vehicle is controlled on a route to a destination, the route being a three-dimensional route. An obstruction is determined on the global route. A local route including alternate points to avoid the obstruction is autonomously determined. The local route is autonomously converged back to the global route in response to avoiding the obstruction.

Abstract: A suture anchor comprises a tubular body having an axial bore therethrough and having one or more purchase enhancements on an exterior surface of the body adapted to enhance purchase of the body within a bone hole, such as threads. A lateral port passes through the body from the bore to the exterior surface and is formed of a slot entering the body from its proximal end. A length of suture for attaching soft tissue to bone passes down along the exterior surface over the one or more purchase enhancements, over a distal end of the body, up into the bore through and then back out of the bore and up along the exterior surface over the one or more purchase enhancements.

Abstract: Embodiments of the present disclosure are directed to a rotatable play device that comprises a central support post, a hub rotatably mounted to an upper end of the central support post, and an arm assembly attached to the hub and comprising a plurality of arms, a seat being suspended from the distal end of each of the plurality of arms. Rotation of the hub about the central support post causes the plurality of seats to rotate around the central support post in a substantially circular rotation path. Each of the seats may also be configured to move up and down by way of a spring assembly or a plurality of springs. Two or more seats may share the up-and-down movement in an alternating manner or each seat may be configured to have an independent up-and-down movement. In addition, each of the seats may optionally be configured to swing in substantial alignment with the circular rotation path and/or to swing outward due to centripetal forces created by the circular rotation path.

Abstract: A technique relates to route planning. Points associated with a start location and a destination location are received. It is determined whether the points comprise one or more hard points, one or more soft points, or both. At least one obstruction to avoid is determined. A route is autonomously generated comprising the points and segments associated with the points, the segments comprising rhumb lines, great-circle arcs, or both. Responsive to the points comprising the one or more soft points, the at least one obstruction is avoided by permitting a distance associated with the one or more soft points to be reached and adding at least one free waypoint. Responsive to the points comprising the one or more hard points, the at least one obstruction is avoided by requiring the one or more hard points to be reached and adding the at least one free waypoint.

Abstract: The present invention relates to conjugates comprising (a) an antisense oligonucleotide (ASO) and (b) at least one G-quadruplex structure, wherein the ASO and the at least one G-quadruplex structure are heterologous to each other. The G-quadruplex of the conjugate may be further conjugated with ligands or functional moieties for addressable delivery and enhanced properties including potency and therapeutic index. Further encompassed are such conjugates for use as a medicament, a method of modulating the stability, translation, splicing, cleavage, or activity of a target nucleic acid molecule using such conjugates, and use of G-quadruplex in stabilizing antisense oligonucleotides.

Abstract: Embodiments of the present disclosure are directed to a rotatable play device that comprises a central support post, a hub rotatably mounted to an upper end of the central support post, and an arm assembly attached to the hub and comprising a plurality of arms, a seat being suspended from the distal end of each of the plurality of arms. Rotation of the hub about the central support post causes the plurality of seats to rotate around the central support post in a substantially circular rotation path. Each of the seats may also be configured to move up and down by way of a spring assembly or a plurality of springs. Two or more seats may share the up-and-down movement in an alternating manner or each seat may be configured to have an independent up-and-down movement. In addition, each of the seats may optionally be configured to swing in substantial alignment with the circular rotation path and/or to swing outward due to centripetal forces created by the circular rotation path.

Abstract: A suture anchor comprises a tubular body having an axial bore therethrough and having one or more purchase enhancements on an exterior surface of the body adapted to enhance purchase of the body within a bone hole, such as threads. A lateral port passes through the body from the bore to the exterior surface. A length of suture for attaching soft tissue to bone passes down along the exterior surface over the one or more purchase enhancements, over a distal end of the body, up into the bore through and then back out of the bore and up along the exterior surface over the one or more purchase enhancements.

Abstract: A hand cropping tool includes arm members that have handle portions and jaw portions. The jaw portions include curved surfaces that are at least partially covered by deformable materials. The hand cropping tool is configured to be moved from an open configuration in which the first and second jaw members are spaced apart from one another and a closed configuration in which at least a portion of the first jaw member is in contact with at least a portion of the second jaw member. In the closed configuration, the first and second deformable materials collectively define at least one first plant-receiving area.

Abstract: A jaw nut of a vise has a threaded bore with at least one opening on an end face. The jaw nut includes an inner annular groove concentric with a centerline of the threaded bore. The inner annular groove has a radius larger than a radius of the at least one opening from the centerline so as to provide at least a portion of an annular flange about the at least one opening having an inner annular surface facing in a direction opposite the end face. A threaded screw supported for rotation on the vise body threadably engages the threaded bore of the jaw nut. A brush seal is disposed in the inner annular groove with an outwardly facing annular surface engaging the inner annular surface of the inner annular groove.

Abstract: A technique relates to autonomous obstacle avoidance. A vehicle is controlled on a route to a destination, the route being a three-dimensional route. An obstruction is determined on the global route. A local route including alternate points to avoid the obstruction is autonomously determined. The local route is autonomously converged back to the global route in response to avoiding the obstruction.

Abstract: Embodiments of the present disclosure are directed to a rotatable play device that comprises a central support post, a hub rotatably mounted to an upper end of the central support post, and an arm assembly attached to the hub and comprising a plurality of arms, a seat being suspended from the distal end of each of the plurality of arms. Rotation of the hub about the central support post causes the plurality of seats to rotate around the central support post in a substantially circular rotation path. Each of the seats may also be configured to move up and down by way of a spring assembly or a plurality of springs. Two or more seats may share the up-and-down movement in an alternating manner or each seat may be configured to have an independent up-and-down movement. In addition, each of the seats may optionally be configured to swing in substantial alignment with the circular rotation path and/or to swing outward due to centripetal forces created by the circular rotation path.

Abstract: The present invention relates to conjugates comprising (a) an antisense oligonucleotide (ASO) and (b) at least one G-quadruplex structure, wherein the ASO and the at least one G-quadruplex structure are heterologous to each other. The G-quadruplex of the conjugate may be further conjugated with ligands or functional moieties for addressable delivery and enhanced properties including potency and therapeutic index. Further encompassed are such conjugates for use as a medicament, a method of modulating the stability, translation, splicing, cleavage, or activity of a target nucleic acid molecule using such conjugates, and use of G-quadruplex in stabilizing antisense oligonucleotides.

Abstract: An artificial reality system includes a head-mounted display (HMD) configured to output artificial reality content, wherein the HMD includes a first wireless transceiver to communicate with one or more devices of the artificial reality system; a peripheral device of the one or more devices of the artificial reality system configured to capture media samples for the HMD to output the artificial reality content, wherein the peripheral device includes a second wireless transceiver to communicate with the HMD; a clock manager of the HMD configured to compute a first delta between a timestamp of the HMD and a timestamp of the first wireless transceiver; and a clock manager of the peripheral device configured to compute a second delta between a timestamp of the peripheral device and a timestamp of the second wireless transceiver, wherein the first delta and the second delta are used to adjust a clock of the peripheral device.

Abstract: An artificial reality system includes a head-mounted display (HMD) configured to output artificial reality content, wherein the HMD includes a first wireless transceiver to communicate with one or more devices of the artificial reality system; a peripheral device of the one or more devices of the artificial reality system configured to capture media samples for the HMD to output the artificial reality content, wherein the peripheral device includes a second wireless transceiver to communicate with the HMD; a clock manager of the HMD configured to compute a first delta between a timestamp of the HMD and a timestamp of the first wireless transceiver; and a clock manager of the peripheral device configured to compute a second delta between a timestamp of the peripheral device and a timestamp of the second wireless transceiver, wherein the first delta and the second delta are used to adjust a clock of the peripheral device.

Abstract: Embodiments of the present disclosure are directed to a rotatable play device that comprises a central support post, a hub rotatably mounted to an upper end of the central support post, and an arm assembly attached to the hub and comprising a plurality of arms, a seat being suspended from the distal end of each of the plurality of arms. Rotation of the hub about the central support post causes the plurality of seats to rotate around the central support post in a substantially circular rotation path. Each of the seats may also be configured to move up and down by way of a spring assembly or a plurality of springs. Two or more seats may share the up-and-down movement in an alternating manner or each seat may be configured to have an independent up-and-down movement. In addition, each of the seats may optionally be configured to swing in substantial alignment with the circular rotation path and/or to swing outward due to centripetal forces created by the circular rotation path.

Abstract: A suture anchor comprises a tubular body having an axial bore therethrough and having one or more purchase enhancements on an exterior surface of the body adapted to enhance purchase of the body within a bone hole, such as threads. A lateral port passes through the body from the bore to the exterior surface. A length of suture for attaching soft tissue to bone passes down along the exterior surface over the one or more purchase enhancements, over a distal end of the body, up into the bore through and then back out of the bore and up along the exterior surface over the one or more purchase enhancements.