Patents by Inventor Brian HEW

Brian HEW has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Evolved integrases and methods of using the same for genome editing
    Patent number: 12378539
    Abstract: Disclosed are evolved Bxb1 and PhiC31 integrases that exhibit increased insertion activity and efficiency as compared to their wild-type counterparts and use of the evolved integrases to modify any sequence within the genome of a cell or subject.
    Type: Grant
    Filed: October 15, 2024
    Date of Patent: August 5, 2025
    Assignee: University of Hawaii
    Inventors: Jesse B. Owens, Brian Hew
  • EVOLVED INTEGRASES AND METHODS OF USING THE SAME FOR GENOME EDITING
    Publication number: 20250043263
    Abstract: Disclosed are evolved Bxb1 and PhiC31 integrases that exhibit increased insertion activity and efficiency as compared to their wild-type counterparts and use of the evolved integrases to modify any sequence within the genome of a cell or subject.
    Type: Application
    Filed: October 15, 2024
    Publication date: February 6, 2025
    Inventors: Jesse B. OWENS, Brian HEW