Patents by Inventor Brian Hicke

Brian Hicke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High affinity nucleic acid ligands to lectins
    Patent number: 6280932
    Abstract: This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: August 28, 2001
    Assignee: Gilead Sciences, Inc.
    Inventors: David H Parma, Brian Hicke, Philippe Bridonneau, Larry Gold
  • Tenascin-C nucleic acid ligands
    Patent number: 6232071
    Abstract: Methods are described for the identification and preparation of nucleic acid ligands to tenascin-C. Included in the invention are specific RNA ligands to tenascin-C identified by the SELEX method. Further included in the invention are methods for detecting the presence of a disease condition in a biological tissue in which tenascin-C is expressed.
    Type: Grant
    Filed: July 29, 1999
    Date of Patent: May 15, 2001
    Assignee: Gilead Sciences, Inc.
    Inventors: Brian Hicke, Stephen Warren, David Parma, Larry Gold
  • High affinity nucleic acid ligands to lectins
    Patent number: 5780228
    Abstract: This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 14, 1998
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: David H. Parma, Brian Hicke, Philippe Bridonneau, Larry Gold