Abstract: Provided herein are compositions comprising a nucleic acid encoding amyloid-beta precursor protein and/or a nucleic acid encoding presenilin-1, cells comprising the compositions, animals comprising the compositions, methods of making the cells and animals, methods of modeling Alzheimer's disease, methods of assessing a therapeutic candidate for the treatment of Alzheimer's disease or amelioration of a symptom or phenotype of Alzheimer's disease, and methods of assessing a therapeutic candidate for the prevention of Alzheimer's disease or prevention of a symptom or phenotype of Alzheimer's disease.

Abstract: The embodiments set forth techniques for encoding information into animated codes. The techniques can include the steps of (1) receiving a request to generate an animated code based on the input data, (2) generating a sequence of visual elements based on the input data, (3) separating the sequence of visual elements into a plurality of visual element groups based on a number of containers that are simultaneously displayed within the animated code, (4) generating a sequence of frames for the animated code, where each frame includes a successive and respective visual element group of the plurality of visual element groups, and the visual elements in the respective visual element group are formatted in accordance with the containers, (5) compiling the sequence of frames to produce the animated code, and (6) integrating the animated code into at least one media item for display on at least one display device.

Abstract: A light-emitting device includes a backplane, light-emitting diodes (LEDs) located over a front side of the backplane, and microlenses respectively disposed over the LEDs. Each microlens includes a back surface having a first surface area and configured to receive light emitted from a corresponding LED, an opposing front surface having a second surface area and configured to emit the received light, and at least one sidewall extending from the front surface to the back surface. The second surface area is greater than the first surface area.

Abstract: Designed polypeptides that bind specifically to a defined protein target are provided, as well as methods for their design and use.

Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.

Abstract: A compound having the structure: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein A, A? and A? are independently O, C?O, C—R? or N—R?, where R? and R? may independently be H, amino, —NR7COR6, COR6, —CONR7R8, C1-C6 alkyl, or hydroxy(C1-C6 alkyl), and R? may be present or absent, and is present where the rules of valency permit, and where not more than one of A, A? and A? is O or C?O; R0 and R are independently H, Br, Cl, F, or C1-C6 alkyl; R1 is H, C1-C6 alkyl, or hydroxy(C1-C6 alkyl); R2 is selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, hydroxy(C1-C6 alkyl), phenyl(C1-C6 alkyl), formyl, heteroaryl, heterocyclic, —COR6, —OCOR6, —COOR6, —NR7COR6, —CONR7R8, and —(CH2)n—W, where W is cyano, hydroxy, C3-C8 cycloalkyl, —SO2NR7R8, and —SO2—R9, where R9 is C1-C6 alkyl, C3-C8 cycloalkyl, heteroaryl, or heterocyclic; wherein each of said alkyl, cycloalkyl, heterocyclic, or heteroaryl may be unsu

Abstract: Bridged compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. wherein R2, R3 R4, R5 and R6 are defined herein.

Abstract: A robotic system navigates a terrain adjacent one or more agricultural crops. The system includes a movable body operable to navigate the ground terrain, a tracking camera configured to generate visual-inertial odometry (VIO) data, a first LiDAR sensor configured to capture a first set of LiDAR data, a second LiDAR sensor configured to capture a second set of LiDAR data, and a controller. The controller is configured to generate terrain navigation instructions utilizing a Monte Carlo Localization algorithm, wherein the Monte Carlo Localization algorithm includes the VIO data from the tracking camera and the first set of LiDAR data.

Abstract: A system for selecting one of multiple paths in a linear drive system includes track segments having a first drive member and at least one mover having a second drive member for the linear drive system. Each mover includes a drive surface oriented toward the track segment when the at least one mover is driven along the track. Each mover also includes a first channel and a second channel extending along the drive surface. A switch track segment includes a first path and a second path along which the at least one mover may travel, at least one first pin positioned along the first path, and at least one second pin positioned along the second path. The first and second pins are extendable to engage the first and second channels of the at least one mover to direct the mover along either the first path or the second path, respectively.

Abstract: Methods and systems for performing advanced analytics based on which features are active by correlating information based on temporal identifiers in feature databases. The method includes receiving a request to change a feature, determining metadata information for the feature, which may include a temporal indicator, a performance metric and a configuration of activation states, and generating a feature change record based on this metadata. The method includes receiving a request to determine a second performance metric, processing the request by determining a second feature change record, determining a configuration and generating a recommendation for display.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Methods and systems for team cooperation with real-time recording of one or more moment-associating elements. For example, a method includes: delivering, in response to an instruction, an invitation to each member of one or more members associated with a workspace; granting, in response to acceptance of the invitation by one or more subscribers of the one or more members, subscription permission to the one or more subscribers; receiving the one or more moment-associating elements; transforming the one or more moment-associating elements into one or more pieces of moment-associating information; and transmitting at least one piece of the one or more pieces of moment-associating information to the one or more subscribers.

Abstract: The present technology has the ability to establish connections between content that do not have direct or explicit relationships. Implicit influence relationships can be established from user download sequence data, campaign data with keyword targeting, and content review data that mentions other content. Using these influence relationships, the relevance of content items can be determined based on the influence relationship of linked content items and a similarity relationship of content items. However, the importance of the influence relationship in ranking content items can vary depending on the parameters against which the content item is considered relevant. To address this, the present technology includes a context-driven factor that is used as a weight to adjust the impact of the influence relationship of the ranking, depending on the parameters against which the content item is considered relevant.

Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.

Abstract: A vehicle battery includes a pouch cell configured to provide power to at least one power system of a vehicle, and multiple electrode foils stacked together at least partially within the pouch cell. Each of the multiple electrode foils includes a foil extension at an end of the electrode foil, a first group of foil extensions are connected together via a first ultrasonic weld to define a first foil extension weld portion, and a second group of foil extensions are connected together via a second ultrasonic weld to define a second foil extension weld portion.

Abstract: A data storage device comprises a disk; a head configured to read data from and write data to the disk; and a current balancer configured to receive a first voltage supply having a load limit and to receive a second voltage supply. The current balancer is further configured, to reduce power consumption, to sample a first current drawn from the first voltage supply, to maintain the first current at a target level that approximately equals the load limit, and to draw a second current from the second voltage supply to satisfy a part of a total load on the first voltage supply that exceeds the load limit.

Abstract: Surgical tools and assemblies are employed for use in minimally invasive surgical (MIS) procedures. A surgical tool assembly includes a handle assembly and a frame assembly. The handle assembly and frame assembly are designed and constructed to have an articulation input joint and a grounding joint between them. A pitch rotational degree of freedom and a yaw rotational degree of freedom are provided by way of the articulation input joint. The handle assembly is translationally constrained relative to the frame assembly by way of the grounding joint. Intermediate bodies and joints can be provided in certain surgical tool assemblies and architectures.

Abstract: A data storage device comprises a disk; a head configured to read data from and write data to the disk; and a current balancer configured to receive a first voltage supply having a load limit and to receive a second voltage supply. The current balancer is further configured, to mitigate rotational vibration (RV) noise, to sample a first current IH5V drawn from the first voltage supply, to maintain a difference between the first current IH5V and a current balancer threshold parameter IThreshold to be at least twice a minimum peak current minCurrentLimitpk amount required for turn on of the current balancer (IH5V?IThreshold?2*minCurrentLimitpk), and to draw a second current from the second voltage supply to satisfy a part of a total load on the first voltage supply that exceeds the load limit.