Patents by Inventor Brian Hutchison

Brian Hutchison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230219043
    Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.
    Type: Application
    Filed: March 6, 2023
    Publication date: July 13, 2023
    Inventors: Darren Roy LINK, John Brian HUTCHISON, Michael L. SAMUELS, Michael WEINER
  • Patent number: 11596908
    Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: March 7, 2023
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Darren Roy Link, John Brian Hutchison, Michael L. Samuels, Michael Weiner
  • Patent number: 11534727
    Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: December 27, 2022
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Darren Link, John Brian Hutchison, Michael Samuels, Michael Weiner
  • Patent number: 11511242
    Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: November 29, 2022
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Darren Roy Link, John Brian Hutchison, Michael L. Samuels, Michael Weiner
  • Publication number: 20220307073
    Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.
    Type: Application
    Filed: June 8, 2022
    Publication date: September 29, 2022
    Inventors: John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link
  • Patent number: 11390917
    Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: July 19, 2022
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link
  • Publication number: 20220143617
    Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
    Type: Application
    Filed: January 24, 2022
    Publication date: May 12, 2022
    Inventors: Benjamin Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Link, Mark Weary
  • Patent number: 11268887
    Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: March 8, 2022
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Benjamin Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Roy Link, Mark Weary
  • Publication number: 20220047998
    Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.
    Type: Application
    Filed: October 25, 2021
    Publication date: February 17, 2022
    Inventors: Darren Roy Link, John Brian Hutchison, Michael L. Samuels, Michael Weiner
  • Publication number: 20200318157
    Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.
    Type: Application
    Filed: April 2, 2020
    Publication date: October 8, 2020
    Inventors: John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link
  • Publication number: 20200225129
    Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
    Type: Application
    Filed: January 2, 2020
    Publication date: July 16, 2020
    Inventors: Benjamin Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Roy Link, Mark Weary
  • Patent number: 10612081
    Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: April 7, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link
  • Patent number: 10527529
    Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: January 7, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Benjamin J. Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Roy Link, Mark Weary
  • Publication number: 20180363050
    Abstract: Described herein are microparticles each comprising a plurality of bound biological molecules. Further described herein is a plurality of microdroplets each comprising one or more primer vehicles. Methods of making and using these microdroplets are also reported. An exemplary microparticle is of Formula (I).
    Type: Application
    Filed: December 7, 2016
    Publication date: December 20, 2018
    Inventors: Brian Hutchison, Darren R. Link, Zuwei Ma, Qun Zhong, Aisling Steele
  • Publication number: 20180353913
    Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.
    Type: Application
    Filed: August 20, 2018
    Publication date: December 13, 2018
    Inventors: Darren Roy Link, Brian Hutchison, Michael L. Samuels, Michael Weiner
  • Publication number: 20170336306
    Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
    Type: Application
    Filed: August 10, 2017
    Publication date: November 23, 2017
    Inventors: Benjamin J. Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Roy Link, Mark Weary
  • Patent number: 9733168
    Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: August 15, 2017
    Assignee: Raindance Technologies, Inc.
    Inventors: Benjamin Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Link, Mark Weary
  • Publication number: 20170028365
    Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.
    Type: Application
    Filed: October 11, 2016
    Publication date: February 2, 2017
    Inventors: Darren Link, Brian Hutchison, Michael Samuels, Michael Weiner
  • Publication number: 20170002400
    Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.
    Type: Application
    Filed: June 22, 2016
    Publication date: January 5, 2017
    Inventors: John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link
  • Patent number: 9498761
    Abstract: Surfactants (e.g., fluorosurfactants) for stabilizing aqueous or hydrocarbon droplets in a fluorophilic continuous phase are presented. In some embodiments, fluorosurfactants include a fluorophilic tail soluble in a fluorophilic (e.g., fluorocarbon) continuous phase, and a headgroup soluble in either an aqueous phase or a lipophilic (e.g., hydrocarbon) phase. The combination of a fluorophilic tail and a headgroup may be chosen so as to create a surfactant with a suitable geometry for forming stabilized reverse emulsion droplets having a disperse aqueous or lipophilic phase in a continuous, fluorophilic phase. In some embodiments, the headgroup is preferably non-ionic and can prevent or limit the adsorption of molecules at the interface between the surfactant and the discontinuous phase. This configuration can allow the droplet to serve, for example, as a reaction site for certain chemical and/or biological reactions.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: November 22, 2016
    Assignees: Raindance Technologies, Inc., President and Fellows of Harvard College
    Inventors: Christian Holtze, David A. Weitz, John Brian Hutchison