Patents by Inventor Brian J. Abraham

Brian J. Abraham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Core transcriptional circuitry in human cells and methods of use thereof
    Patent number: 11319591
    Abstract: Disclosed are methods for identifying the core regulatory circuitry or cell identity program of a cell or tissue, and related methods of diagnoses, screening, and treatment involving the core regulatory circuitry and/or cell identity programs identified using the methods.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: May 3, 2022
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Violaine Saint-Andre, Brian J. Abraham, Zi Peng Fan, Tong Ihn Lee, Richard A. Young
  • METHODS AND ASSAYS FOR MODULATING GENE TRANSCRIPTION BY MODULATING CONDENSATES
    Publication number: 20220120736
    Abstract: Described herein are compositions and methods for modulating gene regulation by modulating condensate formation, composition, maintenance, dissolution and regulation.
    Type: Application
    Filed: March 22, 2019
    Publication date: April 21, 2022
    Inventors: Richard A. Young, Phillip A. Sharp, Arup K. Chakraborty, Alessandra Dall'Agnese, Krishna Shrinivas, Brian J. Abraham, Ann Boija, Eliot Coffey, Daniel S. Day, Yang E. Guo, Nancy M. Hannett, Tong Ihn Lee, Charles H. Li, Isaac Klein, John C. Manteiga, Benjamin R. Sabari, Jurian Schuijers, Abraham S. Weintraub, Alicia V. Zamudio, Lena K. Afeyan, Ozgur Oksuz, Jonathan E. Henninger
  • Transcription Factor Trapping by RNA in Gene Regulatory Elements
    Publication number: 20210269805
    Abstract: Disclosed herein are methods useful for modulating expression of a target gene by modulating binding between a ribonucleic acid (RNA) transcribed from at least one regulatory element of a target gene and a transcription factor which binds to both the RNA and the regulatory element. Also disclosed herein are methods and assays for identifying agents that interfere with binding between RNA transcribed from at least one regulatory element and a transcription factor which binds to the RNA and to the regulatory element.
    Type: Application
    Filed: March 30, 2021
    Publication date: September 2, 2021
    Inventors: Richard A. Young, Alla A. Sigova, Brian J. Abraham
  • Transcription Factor Trapping by RNA in Gene Regulatory Elements
    Publication number: 20190062752
    Abstract: Disclosed herein are methods useful for modulating expression of a target gene by modulating binding between a ribonucleic acid (RNA) transcribed from at least one regulatory element of a target gene and a transcription factor which binds to both the RNA and the regulatory element. Also disclosed herein are methods and assays for identifying agents that interfere with binding between RNA transcribed from at least one regulatory element and a transcription factor which binds to the RNA and to the regulatory element.
    Type: Application
    Filed: October 28, 2016
    Publication date: February 28, 2019
    Inventors: Richard A. Young, Alla A. Sigova, Brian J. Abraham
  • CORE TRANSCRIPTIONAL CIRCUITRY IN HUMAN CELLS AND METHODS OF USE THEREOF
    Publication number: 20170327890
    Abstract: Disclosed are methods for identifying the core regulatory circuitry or cell identity program of a cell or tissue, and related methods of diagnoses, screening, and treatment involving the core regulatory circuitry and/or cell identity programs identified using the methods.
    Type: Application
    Filed: December 23, 2016
    Publication date: November 16, 2017
    Inventors: Violaine Saint-Andre, Brian J. Abraham, Zi Peng Fan, Tong Ihn Lee, Richard A. Young
  • Core Transcriptional Circuitry in Human Cells and Methods of Use Thereof
    Publication number: 20150337376
    Abstract: Disclosed herein are methods for identifying the core regulatory circuitry or cell identity program of a cell or tissue, and related methods of diagnoses, screening, and treatment involving the core regulatory circuitry and/or cell identity programs identified using the methods.
    Type: Application
    Filed: March 19, 2015
    Publication date: November 26, 2015
    Inventors: Violaine Saint-Andre, Brian J. Abraham, Zi Peng Fan, Tong Ihn Lee, Richard A. Young