Patents by Inventor Brian J. Cox

Brian J. Cox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10660648
    Abstract: A vascular occlusion device includes a braided filament mesh structure defining a longitudinal axis. The mesh structure has a relaxed configuration in which it has an axial array of radially-extending occlusion regions, each of which has a proximal side and a distal side meeting at a peripheral edge, the sides of each occlusion region forming a first angle relative to the longitudinal axis. Each occlusion region is axially separated from the adjacent occlusion region by a reduced-diameter connecting region. The mesh structure is radially compressible to a compressed state in which it is deployed intravascularly to a target site through a catheter. Upon deployment, the device radially expands to a constrained configuration in which the peripheral edges of the occlusion regions engage the vascular wall, and the sides of the occlusion regions form a second angle relative to the longitudinal axis that is smaller than the first angle.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: May 26, 2020
    Assignee: Inceptus Medical, LLC
    Inventors: Paul Lubock, Richard Quick, Robert Rosenbluth, Brian J. Cox
  • Publication number: 20200146689
    Abstract: In a system and method for deployment of an implant device, the implant device includes a first loop at its proximal end, and a deployment tool has a second loop attached at its distal end. A release wire slidably disposed within the deployment tool has a distal end extending through the first and second loops to releasably couple the implant device to the deployment tool, and a proximal portion extending from a proximal end of the deployment tool, which is held in a retraction device. The retraction device is operable to hold the proximal end of the deployment tool and to pull the release wire proximally through the deployment tool until the distal end of the release wire is withdrawn from the first and second loops to decouple the implant device from the deployment tool.
    Type: Application
    Filed: January 10, 2020
    Publication date: May 14, 2020
    Applicant: Inceptus Medical LLC
    Inventors: Martin Shabaz, Claudio Plaza, Richard Quick, Paul Lubock, Brian J. Cox
  • Patent number: 10610231
    Abstract: Methods for treatment of a cerebral aneurysm within a cerebral vasculature of a patient are described. A microcatheter and a device for treatment of the aneurysm are provided. The device is a self-expanding resilient permeable shell having a plurality of elongate resilient filaments with a woven structure. The plurality of filaments includes small and large filaments. The filaments are bundled and secured to each other at a proximal end. A ratio of the total cross-sectional area of small filaments to the total cross-sectional area of large filaments may be between 0.56 and 1.89. The distal end of the microcatheter is advanced to a region of interest within a cerebral artery. The device is advanced through the lumen and out of the distal end of the microcatheter such that the permeable shell deploys and expands within the cerebral aneurysm. The microcatheter is then withdrawn from the cerebral artery.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: April 7, 2020
    Assignee: SEQUENT MEDICAL, INC.
    Inventors: Philippe Marchand, Brian J. Cox, Robert F. Rosenbluth
  • Patent number: 10604555
    Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particularly the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH). The peptides comprise a lysine residue at a position corresponding to position 24 of hGIP(1-31), and comprise a negatively charged modifying group attached to the epsilon amino group of the lysine residue.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: March 31, 2020
    Assignee: Novo Nordisk A/S
    Inventors: Wouter Frederik Johan Hogendorf, Henning Thoegersen, Nicholas Raymond Cox, Patrick J. Knerr, Richard DiMarchi, Brian Finan, Jesper F. Lau, Steffen Reedtz-Runge, Fa Liu
  • Patent number: 10588655
    Abstract: A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: March 17, 2020
    Assignee: Inari Medical, Inc.
    Inventors: Robert F. Rosenbluth, Brian J. Cox, Paul Lubock
  • Patent number: 10531877
    Abstract: In a system and method for deployment of an implant device, the implant device includes a first loop at its proximal end, and a deployment tool has a second loop attached at its distal end. A release wire slidably disposed within the deployment tool has a distal end extending through the first and second loops to releasably couple the implant device to the deployment tool, and a proximal portion extending from a proximal end of the deployment tool, which is held in a retraction device. The retraction device is operable to hold the proximal end of the deployment tool and to pull the release wire proximally through the deployment tool until the distal end of the release wire is withdrawn from the first and second loops to decouple the implant device from the deployment tool.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: January 14, 2020
    Assignee: INCEPTUS MEDICAL LLC
    Inventors: Martin Shabaz, Claudio Plaza, Richard Quick, Paul Lubock, Brian J. Cox
  • Patent number: 10524811
    Abstract: Systems and methods for treating thrombosis and or emboli in a peripheral vasculature of a patient are disclosed herein. The method can include providing a thrombus extraction device including a proximal self-expanding coring portion formed of a unitary fenestrated structure and a distal expandable tubular portion formed of a braided filament mesh structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus in a vessel; deploying the thrombus extraction device from the catheter from a constrained configuration to an expanded configuration; retracting the thrombus extraction device proximally so that the coring portion cores and separates a portion of the vascular thrombus from the venous vessel wall while the mesh structure captures the vascular thrombus portion; and withdrawing the thrombus extraction device from the patient to remove the vascular thrombus portion from the vessel.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: January 7, 2020
    Assignee: Inari Medical, Inc.
    Inventors: Phil Marchand, John C. Thress, Jacob F. Louw, Brian J. Cox, Richard Quick
  • Publication number: 20190367578
    Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particular the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH).
    Type: Application
    Filed: May 3, 2019
    Publication date: December 5, 2019
    Inventors: Wouter Frederik Johan Hogendorf, Henning Thoegersen, Nicholas Raymond Cox, Patrick J. Knerr, Richard DiMarchi, Brian Finan, Jesper F. Lau, Steffen Reedtz-Runge, Fa Liu
  • Publication number: 20190321071
    Abstract: Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a unitary fenestrated structure, a distal substantially cylindrical portion formed of a net-like filament mesh structure, and an inner shaft member connected to a distal end of the net-like filament mesh structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction; retracting the thrombus extraction device to separate a portion of the thrombus from the vessel wall and to capture the portion of the thrombus within the net-like filament mesh structure; and withdrawing the thrombus extraction device from the body to remove thrombus from the patient.
    Type: Application
    Filed: May 29, 2019
    Publication date: October 24, 2019
    Inventors: Phil Marchand, John C. Thress, Jacob F. Louw, Brian J. Cox, Richard Quick
  • Publication number: 20190307464
    Abstract: A vascular occlusion device includes a braided filament mesh structure defining a longitudinal axis. The mesh structure has a relaxed configuration in which it has an axial array of radially-extending occlusion regions, each of which has a proximal side and a distal side meeting at a peripheral edge, the sides of each occlusion region forming a first angle relative to the longitudinal axis. Each occlusion region is axially separated from the adjacent occlusion region by a reduced-diameter connecting region. The mesh structure is radially compressible to a compressed state in which it is deployed intravascularly to a target site through a catheter. Upon deployment, the device radially expands to a constrained configuration in which the peripheral edges of the occlusion regions engage the vascular wall, and the sides of the occlusion regions form a second angle relative to the longitudinal axis that is smaller than the first angle.
    Type: Application
    Filed: June 25, 2019
    Publication date: October 10, 2019
    Inventors: Paul Lubock, Richard Quick, Robert Rosenbluth, Brian J. Cox
  • Patent number: 10376267
    Abstract: A vascular occlusion device includes a braided filament mesh structure defining a longitudinal axis. The mesh structure has a relaxed configuration in which it has an axial array of radially-extending occlusion regions, each of which has a proximal side and a distal side meeting at a peripheral edge, the sides of each occlusion region forming a first angle relative to the longitudinal axis. Each occlusion region is axially separated from the adjacent occlusion region by a reduced-diameter connecting region. The mesh structure is radially compressible to a compressed state in which it is deployed intravascularly to a target site through a catheter. Upon deployment, the device radially expands to a constrained configuration in which the peripheral edges of the occlusion regions engage the vascular wall, and the sides of the occlusion regions form a second angle relative to the longitudinal axis that is smaller than the first angle.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: August 13, 2019
    Assignee: Inceptus Medical, LLC
    Inventors: Paul Lubock, Richard Quick, Robert Rosenbluth, Brian J. Cox
  • Publication number: 20190218696
    Abstract: Methods of braiding using a braiding mechanism are described. The braiding machine includes first and second annular members, the second annular member being concentric with the first annular member. A mandrel extends perpendicularly to and intersects a horizontal plane defined by a substantially circular region of the second annular member substantially at the center of the circular region. Each of the annular members has a plurality of tubular guide wires slideably mounted thereon and a plurality of wires extend from the mandrel through each of the tubular wire guides. The first annular member rotates circumferentially relative to the second annular member. The first plurality of tubular wire guides slides radially inward to align with the second annular member, and the second plurality of tubular wire guides slides radially outward so as to align with the first annular member.
    Type: Application
    Filed: February 27, 2019
    Publication date: July 18, 2019
    Applicant: SEQUENT MEDICAL, INC.
    Inventors: James M. Thompson, Brian J. Cox, Robert Rosenbluth, Philippe Marchand, John Nolting, Darrin J. Kent, Tan Q. Dinh, Hung P. Tran, James A. Milburn
  • Patent number: 10342571
    Abstract: Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a unitary fenestrated structure, a distal substantially cylindrical portion formed of a net-like filament mesh structure, and an inner shaft member connected to a distal end of the net-like filament mesh structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction; retracting the thrombus extraction device to separate a portion of the thrombus from the vessel wall and to capture the portion of the thrombus within the net-like filament mesh structure; and withdrawing the thrombus extraction device from the body to remove thrombus from the patient.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: July 9, 2019
    Assignee: Inari Medical, Inc.
    Inventors: Phil Marchand, John C. Thress, Jacob F. Louw, Brian J. Cox, Richard Quick
  • Patent number: 10335186
    Abstract: A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: July 2, 2019
    Assignee: Inari Medical, Inc.
    Inventors: Robert F. Rosenbluth, Brian J. Cox, Paul Lubock
  • Patent number: 10305826
    Abstract: A system and method simulates conversation with a human user. The system and method receive media, convert the media into a system-specific format, and compare the converted media to a vocabulary. The system and method generate a plurality of intents and a plurality of sub-entities and transform them into a pre-defined format. The system and method route intents and the sub-entities to a first selected knowledge engine and a second knowledge engine. The first selected knowledge engine selects the second knowledge engine and each active grammar in the vocabulary uniquely identifies each of the knowledge engines.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: May 28, 2019
    Assignee: Progressive Casualty Insurance Company
    Inventors: Matthew T. White, Brian J. Surtz, Callen C. Cox
  • Publication number: 20190150959
    Abstract: A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member having a plurality of first clot engagement members and second clot engagement members positioned about the circumference of a distal portion of the support member. In an undeployed state, individual first clot engagement members can be linear and have a first length, and individual second clot engagement members can be linear and have a second length that is less than the first length. The clot engagement members can be configured to penetrate clot material along an arcuate path and hold clot material to the clot treatment device.
    Type: Application
    Filed: December 18, 2018
    Publication date: May 23, 2019
    Inventors: Brian J. Cox, Paul Lubock, Robert Rosenbluth, Richard Quick, Philippe Marchand
  • Publication number: 20190133600
    Abstract: In a system and method for deployment of an implant device, the implant device includes a first loop at its proximal end, and a deployment tool has a second loop attached at its distal end. A release wire slidably disposed within the deployment tool has a distal end extending through the first and second loops to releasably couple the implant device to the deployment tool, and a proximal portion extending from a proximal end of the deployment tool, which is held in a retraction device. The retraction device is operable to hold the proximal end of the deployment tool and to pull the release wire proximally through the deployment tool until the distal end of the release wire is withdrawn from the first and second loops to decouple the implant device from the deployment tool.
    Type: Application
    Filed: November 9, 2018
    Publication date: May 9, 2019
    Applicant: Inceptus Medical LLC
    Inventors: Martin Shabaz, Claudio Plaza, Richard Quick, Paul Lubock, Brian J. Cox
  • Patent number: 10260182
    Abstract: Methods of braiding using a braiding mechanism are described. The braiding mechanism includes a circular array of filament engagement elements, a mandrel extending from the center of the circular array, a plurality of actuators disposed operably about the circular array, and a rotating mechanism adapted to rotate one or more filaments. The circular array of filament engagement elements and the plurality of actuators are configured to move relative to one another. The plurality of filaments are loaded onto the mandrel and extend radially toward and contact the circumferential edge of the circular array of filament engagement elements. The plurality of actuators are operated to engage a first subset of the plurality of filaments and move the engaged filaments in a generally radial direction to a position beyond the circumferential edge of the circular array. The rotating mechanism is operated to move the engaged filaments about the mandrel axis.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: April 16, 2019
    Assignee: Sequent Medical, Inc.
    Inventors: James M Thompson, Brian J Cox, Robert Rosenbluth, Philippe Marchand, John Nolting, Darrin J Kent, Tan Q Dinh, Hung P Tran, James A Milburn
  • Patent number: 10238393
    Abstract: Devices and methods for treatment of a patient's vasculature with some embodiments configured for delivery with a microcatheter for treatment of the cerebral vasculature of a patient. Some embodiments may include a permeable shell and inner structure configured to occlude blood flow therethrough.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: March 26, 2019
    Assignee: SEQUENT MEDICAL INC.
    Inventors: Philippe Marchand, Brian J. Cox, Robert F. Rosenbluth, John Nolting, Tan Q. Dinh
  • Patent number: 10238406
    Abstract: A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member having a plurality of first clot engagement members and second clot engagement members positioned about the circumference of a distal portion of the support member. In an undeployed state, individual first clot engagement members can be linear and have a first length, and individual second clot engagement members can be linear and have a second length that is less than the first length. The clot engagement members can be configured to penetrate clot material along an arcuate path and hold clot material to the clot treatment device.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: March 26, 2019
    Assignee: Inari Medical, Inc.
    Inventors: Brian J. Cox, Paul Lubock, Robert Rosenbluth, Richard Quick, Philippe Marchand