Patents by Inventor Brian J. Day

Brian J. Day has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11986450
    Abstract: The present invention generally relates to methods and compositions for treating pulmonary infections and inflammation with a composition comprising selenocyanate, hyposelenocyanite or a selenocyanate conjugate.
    Type: Grant
    Filed: May 3, 2022
    Date of Patent: May 21, 2024
    Assignee: National Jewish Health
    Inventors: Brian J. Day, Preston E. Bratcher
  • Publication number: 20230000830
    Abstract: Compounds may be administered to prevent or rescue organ injury following exposure to alkylating agents, such as sulfur mustards. The compounds may be substituted metalloporphyrins.
    Type: Application
    Filed: May 3, 2022
    Publication date: January 5, 2023
    Inventors: Brian J. Day, Carl W. White
  • Publication number: 20220280467
    Abstract: The present invention generally relates to methods and compositions for treating pulmonary infections and inflammation with a composition comprising selenocyanate, hyposelenocyanite or a selenocyanate conjugate.
    Type: Application
    Filed: May 3, 2022
    Publication date: September 8, 2022
    Inventors: Brian J. Day, Preston E. Bratcher
  • Patent number: 11382895
    Abstract: Compounds may be administered to prevent or rescue organ injury following exposure to alkylating agents, such as sulfur mustards. The compounds may be substituted metalloporphyrins.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: July 12, 2022
    Assignee: National Jewish Health
    Inventors: Brian J. Day, Carl W. White
  • Patent number: 11351141
    Abstract: The present invention generally relates to methods and compositions for treating pulmonary infections and inflammation with a composition comprising selenocyanate, hyposelenocyanite or a selenocyanate conjugate.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: June 7, 2022
    Assignee: National Jewish Health
    Inventors: Brian J. Day, Preston E. Bratcher
  • Patent number: 11166981
    Abstract: The invention provides methods and compositions for treating and/or preventing chlorine-gas induced lung injury with sodium thiosulfate.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: November 9, 2021
    Assignee: National Jewish Health
    Inventor: Brian J. Day
  • Publication number: 20210030706
    Abstract: The present invention generally relates to methods and compositions for treating pulmonary infections and inflammation with a composition comprising selenocyanate, hyposelenocyanite or a selenocyanate conjugate.
    Type: Application
    Filed: July 20, 2020
    Publication date: February 4, 2021
    Inventors: Brian J. Day, Preston E. Bratcher
  • Publication number: 20200316108
    Abstract: The invention provides methods and compositions for treating and/or preventing chlorine-gas induced lung injury with sodium thiosulfate.
    Type: Application
    Filed: April 3, 2020
    Publication date: October 8, 2020
    Inventor: Brian J. Day
  • Patent number: 10751315
    Abstract: The present invention generally relates to methods and compositions for treating pulmonary infections and inflammation with a composition comprising selenocyanate, hyposelenocyanite or a selenocyanate conjugate.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: August 25, 2020
    Assignee: National Jewish Health
    Inventors: Brian J. Day, Preston E. Bratcher
  • Publication number: 20190083440
    Abstract: The present invention generally relates to methods and compositions for treating pulmonary infections and inflammation with a composition comprising selenocyanate, hyposelenocyanite or a selenocyanate conjugate.
    Type: Application
    Filed: August 29, 2018
    Publication date: March 21, 2019
    Inventors: Brian J. Day, Preston E. Bratcher
  • Publication number: 20180251483
    Abstract: Described herein, inter alia, are thiocyanate salt compositions and methods for treating or preventing inflammation using the same.
    Type: Application
    Filed: October 12, 2017
    Publication date: September 6, 2018
    Inventors: Brian J. Day, John McManus
  • Patent number: 9289434
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: March 22, 2016
    Assignees: Aeolus Sciences, Inc., National Jewish Health, Duke University
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • Publication number: 20150231150
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Application
    Filed: December 18, 2014
    Publication date: August 20, 2015
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • Patent number: 8946202
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: February 3, 2015
    Assignees: Aeolus Sciences, Inc., National Jewish Health, Duke University
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • Patent number: 8765729
    Abstract: The present invention relates, in general, to cancer therapy, and, in particular, to a method of preventing or treating cancer using low molecular weight antioxidants (e.g., mimetics of superoxide dismutase (SOD)) as the active agent or as a chemo- and/or radio-protectant. The invention also relates to compounds and compositions suitable for use in such a method.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: July 1, 2014
    Assignees: Aeolus Sciences, Inc., Duke University, National Jewish Medical and Research Center
    Inventors: James D. Crapo, Brian J. Day, Ines Batinic-Haberle, Richard Gammans, Zeljko Vusjaskovic
  • Publication number: 20140162986
    Abstract: Methods for therapy of cystic fibrosis and other conditions are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis and/or another condition responsive to stimulation of thiol-containing compound transport.
    Type: Application
    Filed: February 13, 2014
    Publication date: June 12, 2014
    Applicant: NATIONAL JEWISH MEDICAL AND RESEARCH CENTER
    Inventors: Brian J. Day, Leonard W. Velsor
  • Publication number: 20140011794
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Application
    Filed: September 5, 2013
    Publication date: January 9, 2014
    Applicants: Aeouls Sciences, Inc., Duke University, National Jewish Health
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • Patent number: 8546562
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: October 1, 2013
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • Patent number: 8470808
    Abstract: The present invention relates, in one embodiment, to a method of preventing or treating diabetes using low molecular weight antioxidants. In a further embodiment, the invention relates to a method of protecting and/or enhancing viability of cells/tissues/organs during isolation (harvesting), preservation, expansion and/or transplantation. In yet another embodiment, the present invention relates to a method of inducing immune tolerance. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: June 25, 2013
    Inventors: Jon D. Piganelli, Kathryn Haskins, Sonia C. Flores, James D. Crapo, Brian J. Day, Ronald G. Gill, Richard Gammans, Manisha Patel
  • Publication number: 20120214780
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Application
    Filed: April 26, 2012
    Publication date: August 23, 2012
    Applicants: AEOLUS SCIENCES, INC., DUKE UNIVERSITY, NATIONAL JEWISH HEALTH
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle