Patents by Inventor Brian J. Frankowski
Brian J. Frankowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11918727Abstract: An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment. The system further includes a fiber bundle with a plurality of hollow gas permeable fibers extending generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet.Type: GrantFiled: May 24, 2021Date of Patent: March 5, 2024Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University, Mississippi State UniversityInventors: Shalv Madhani, Brian Joseph Frankowski, William J. Federspiel, Gregory Burgreen, James F. Antaki
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Patent number: 9296990Abstract: An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.Type: GrantFiled: September 26, 2013Date of Patent: March 29, 2016Assignees: New Health Sciences, Inc., University of Pittsburgh-of the Commonwealth System of Higher EducationInventors: William J. Federspiel, Brian J. Frankowski, Tatsuro Yoshida, Paul J. Vernucci
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Publication number: 20140228741Abstract: A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between intracorporeal fluid and an interior of the hollow fibers. The plurality of hollow fibers is positioned radially outward from the agitation mechanisms. A blood contacting medical system includes at least one seal, and a purge system via which a flushing fluid is introduced under pressure over a blood-side face of the seal and caused to flow through a space on the blood side of the seal. The system can further include a rotatable member. The space on the blood side of the seal can be in fluid connection with an annular space adjacent to a rotating element operatively connected to the rotatable member.Type: ApplicationFiled: April 14, 2014Publication date: August 14, 2014Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: BRIAN J. FRANKOWSKI, WILLIAM J. FEDERSPIEL, KEVIN M. MIHELC, SAMUEL C. LIEBER
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Patent number: 8734382Abstract: A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adapted to permit diffusion of a gas between an intracorporeal fluid and an interior of the hollow fibers. The plurality of hollow fibers is positioned radially outward from the agitation mechanisms. A blood contacting medical system includes at least one seal, and a purge system via which a flushing fluid is introduced under pressure over a blood-side face of the at least one seal and caused to flow through a space on the blood-side face of the at least one seal. The system can further include a rotatable member. The space on the blood-side face of the at least one seal can be in fluid connection with an annular space adjacent to a rotating element operatively connected to the rotatable member.Type: GrantFiled: February 6, 2009Date of Patent: May 27, 2014Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Brian J. Frankowski, William J. Federspiel, Kevin M. Mihelc, Samuel C. Lieber
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Publication number: 20140065016Abstract: A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is introduced to the center of the device and is passed radially through the fiber bundle. The bundle is rotated at rapidly changing velocities with a rotational actuator (for example, a motor or magnetic coupling). The rotation of the fiber bundle provides centrifugal kinetic energy to the fluid giving the device pumping capabilities and may create Taylor vortexes to increase mass transfer. Rotation of the fiber bundle increases the relative velocity between the fluid and the hollow fibers and increases the mass transfer. The porosity of the fiber bundle may be varied to enhance gas exchange with the blood. Alternatively, a rotating core may be used with a stationary fiber bundle.Type: ApplicationFiled: April 11, 2011Publication date: March 6, 2014Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: William J. FEDERSPIEL, Brian J. FRANKOWSKI, Brendan C. MACK, Scott W. MORLEY, Meir ROSENBERG, Robert G. SVITEK
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Patent number: 8647569Abstract: A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is introduced to the center of the device and is passed radially through the fiber bundle. The bundle is rotated at rapidly changing velocities with a rotational actuator (for example, a motor or magnetic coupling). The rotation of the fiber bundle provides centrifugal kinetic energy to the fluid giving the device pumping capabilities and may create Taylor vortexes to increase mass transfer. Rotation of the fiber bundle increases the relative velocity between the fluid and the hollow fibers and increases the mass transfer. The porosity of the fiber bundle may be varied to enhance gas exchange with the blood. Alternatively, a rotating core may be used with a stationary fiber bundle.Type: GrantFiled: April 11, 2011Date of Patent: February 11, 2014Assignee: ALung Technologies, IncInventors: William J. Federspiel, Brian J. Frankowski, Brendan C. Mack, Scott W. Morley, Meir Rosenberg, Robert G. Svitek
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Publication number: 20140030694Abstract: An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.Type: ApplicationFiled: September 26, 2013Publication date: January 30, 2014Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, New Health Sciences, Inc.Inventors: William J. FEDERSPIEL, Brian J. FRANKOWSKI, Tatsuro YOSHIDA, Paul J. VERNUCCI
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Patent number: 8569052Abstract: An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.Type: GrantFiled: May 25, 2011Date of Patent: October 29, 2013Assignees: New Health Sciences, Inc., University of Pittsburgh-Of the Commonwealth System of Higher EducationInventors: William J. Federspiel, Brian J. Frankowski, Tatsuro Yoshida, Paul J. Vernucci
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Publication number: 20120100523Abstract: An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.Type: ApplicationFiled: May 25, 2011Publication date: April 26, 2012Inventors: William J. Federspiel, Brian J. Frankowski, Tatsuro Yoshida, Paul J. Vernucci
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Patent number: 7927544Abstract: A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is introduced to the center of the device and is passed radially through the fiber bundle. The bundle is rotated at rapidly changing velocities with a rotational actuator (for example, a motor or magnetic coupling). The rotation of the fiber bundle provides centrifugal kinetic energy to the fluid giving the device pumping capabilities and may create Taylor vortexes to increase mass transfer. Rotation of the fiber bundle increases the relative velocity between the fluid and the hollow fibers and increases the mass transfer. The porosity of the fiber bundle may be varied to enhance gas exchange with the blood. Alternatively, a rotating core may be used with a stationary fiber bundle.Type: GrantFiled: April 21, 2006Date of Patent: April 19, 2011Assignee: Alung Technologies, Inc.Inventors: William J. Federspiel, Brian J. Frankowski, Brendan C. Mack, Scott W. Morley, Meir Rosenberg, Robert G. Svitek
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Publication number: 20100331767Abstract: A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between intracorporeal fluid and an interior of the hollow fibers. The plurality of hollow fibers is positioned radially outward from the agitation mechanisms. A blood contacting medical system includes at least one seal, and a purge system via which a flushing fluid is introduced under pressure over a blood-side face of the seal and caused to flow through a space on the blood side of the seal. The system can further include a rotatable member. The space on the blood side of the seal can be in fluid connection with an annular space adjacent to a rotating element operatively connected to the rotatable member.Type: ApplicationFiled: February 6, 2009Publication date: December 30, 2010Inventors: Brian J. Frankowski, William J. Federspiel, Kevin M. Mihelc, Samuel C. Lieber
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Publication number: 20040225233Abstract: A system for placement of a medical device in a body passage including a first and second guidewire, each configured with magnets on their distal ends. The guidewires are inserted through different access sites of a body passage and blindly connected using the magnets. The first guidewire is inserted into a first insertion site and the second guidewire is inserted into a second insertion site. Once the distal ends of the guidewires are attached, the second guidewire can then be removed from the first insertion site, detached from the first guidewire and attached to a medical device. The distal end of the second guidewire can then be pulled through the second insertion site to guide the medical device into a desired location in the body passage.Type: ApplicationFiled: May 9, 2003Publication date: November 11, 2004Inventors: Brian J. Frankowski, William J. Federspiel, Joseph F. Golob, Brack G. Hattler