Abstract: The invention provides for a method for selectively reducing the expression of a mutant mRNA and/or protein having an expanded nucleotide repeat relative to a wild-type mRNA, comprising contacting a cell with an antisense oligonucleotide of sufficient length and complementarity to the expanded nucleotide repeat. More particularly it relates to selectively reducing the expression of mutant Huntington protein associated with Huntington's disease. The antisense oligonucleotide comprising either a nucleotide or a repeated three nucleotide sequence as defined in the claims.

Abstract: A vehicle includes a vehicle frame, a saddle-type seat mounted to the frame and having a forward portion and a rearward portion, a cargo area defining a storage compartment positioned at least partially rearward of the saddle-type seat, and a rider support assembly positioned rearward of the forward portion of the saddle-type seat and vertically above at least a portion of the saddle-type seat and the storage compartment.

Abstract: Polypectomy devices and methods for making and using polypectomy devices are disclosed. An example polypectomy device may include an elongate sheath having a proximal end region and a distal end region. A shaft may be slidably disposed within the sheath. A handle may be coupled to the proximal end region of the sheath. The handle may be designed to axially shift the shaft relative to the sheath. A snare may be coupled to the shaft. The snare may include a first region, a traction region, and a distal tip region. The first region may have a non-circular cross-sectional shape. The traction region may include a plurality of traction members. At a position between two adjacent traction members the snare may have a reduced cross-sectional area relative to the first region. The distal tip region may have a circular cross-sectional shape.

Abstract: Polypectomy devices and methods for making and using polypectomy devices are disclosed. An example polypectomy device may include an elongate sheath having a proximal end region and a distal end region. A shaft may be slidably disposed within the sheath. A handle may be coupled to the proximal end region of the sheath. The handle may be designed to axially shift the shaft relative to the sheath. A snare may be coupled to the shaft. The snare may include a first region, a traction region, and a distal tip region. The first region may have a non-circular cross-sectional shape. The traction region may include a plurality of traction members. At a position between two adjacent traction members the snare may have a reduced cross-sectional area relative to the first region. The distal tip region may have a circular cross-sectional shape.

Abstract: A guide extension catheter may include a proximal shaft and a tubular distal sheath including an exchange channel allowing for access (e.g. side access) into the lumen. Guide extension catheters may be used in conjunction with a guide catheter and a medical device having a distal region disposed within the guide catheter and a proximal region disposed outside of the guide catheter. A portion of the proximal region of the medical device can be passed through the exchange channel and into the lumen, and the guide extension catheter can be advanced into the guide catheter over the medical device without removing the medical device from the guide catheter. The exchange channel can extend in a straight line path along the sheath, or may extend in an indirect path along the sheath.

Abstract: Exemplary embodiments of the present disclosure relate to devices, systems, and methods for tissue resection in a body lumen of a patient, and may include an endoscope and a backstop delivery device extendable through the endoscope. The backstop delivery device may deliver a backstop to a location of selected tissue for resection. A backstop may include a covering being deployable in a patient. The covering may have one or more anchoring mechanisms disposed on an edge of the covering. A tissue resecting device may be extendable through the endoscope for resecting the selected tissue for resection. The covering may be deployable to an outer surface of the body lumen, such that the anchoring mechanism may secure the covering to the outer surface of the body lumen and the covering may expand to cover the selected tissue for resection.

Abstract: Devices and methods for assisting blood flow are provided. The device includes a housing with an inlet and an outlet, and a fluid barrier separating the housing into a first section containing the inlet and outlet, and a second section. The device also includes an impeller shaft coupled to an impeller and a first magnet in the first section of the housing, and a drive shaft coupled to a second magnet in the second section of the housing. The first and second magnets are arranged such that rotation of the drive shaft rotates the second magnet causing rotation of the first magnet, which drives the impeller.

Abstract: Polypectomy devices and methods for making and using polypectomy devices are disclosed. An example polypectomy device may include an elongate sheath having a proximal end region and a distal end region. A shaft may be slidably disposed within the sheath. A handle may be coupled to the proximal end region of the sheath. The handle may be designed to axially shift the shaft relative to the sheath. A snare may be coupled to the shaft. The snare may include a first region, a traction region, and a distal tip region. The first region may have a non-circular cross-sectional shape. The traction region may include a plurality of traction members. At a position between two adjacent traction members the snare may have a reduced cross-sectional area relative to the first region. The distal tip region may have a circular cross-sectional shape.

Abstract: An elongate medical device may have an elongate tubular body including a proximal portion configured for isotropic bending and a distal portion configured for anisotropic bending. A first steering wire may extend through a first plurality of steering wire guides formed along a first side of the distal region of the elongate tubular body and a second steering wire may extend through a second plurality of steering wire guides formed along a second side of the distal region of the elongate tubular body.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a medical device for measuring blood pressure. The medical device may include an elongated shaft having a proximal region and a distal region and a lumen extending therethrough and an optical pressure sensing block disposed within the lumen, the optical pressure sensing block including a distal portion bearing a pressure sensing membrane and a proximal portion forming an optical fiber connector extending proximally from the proximal portion. The optical fiber connector may be configured to be coupled to an optical fiber extending through the lumen.

Abstract: A slip ring has a rotating portion configured to take in signals from rotating electric transmission elements, and communicate those signals into a static portion. The rotating portion has a plurality of resistors which rotate. The resistors have an outer peripheral surface, and a containment ring surrounding the outer peripheral surface of the plurality of resistors. A method of testing a rotating component is also disclosed.

Abstract: A method of manufacturing a medical device is disclosed. The method comprises laser cutting a tubular member. The tubular member may have an inner surface, an outer surface and a tubular wall defining a thickness extending therebetween. The method may also include laser cutting the member. Laser cutting may include removing a portion of the thickness of the tubular wall at one or more discrete locations along the tubular wall. The method may also include chemically etching the one or more discrete locations to form a slot within the tubular wall at the one or more discrete locations along the tubular member.

Abstract: A slip ring has a rotating portion configured to take in signals from rotating electric transmission elements, and communicate those signals into a static portion. The rotating portion has a plurality of resistors which rotate. The resistors have an outer peripheral surface, and a containment ring surrounding the outer peripheral surface of the plurality of resistors. A method of testing a rotating component is also disclosed.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device includes a pressure sensing guidewire. The pressure sensing guidewire may include an elongate shaft including a core wire having a distal portion and a coil disposed over the distal portion. A pressure sensor may be disposed along the distal portion of the core wire and within the coil. One or more leads may be coupled to the pressure sensor. An opening may be formed in the coil that provides access to the pressure sensor.

Abstract: An apparatus for cutting a planar medical component having a first surface and a second surface, comprising a clamp for fixing the component and applying a tensile force, a support having a surface having a hole therein, the upper surface disposed proximate the second surface of the component, and a cutting device having a cutting head disposed proximate the support and facing the first surface, wherein the support is configured to move along the plane of the component relative to the clamp and the cutting device cutting head is configured to hold position relative to the support.

Abstract: A method for manipulating a portion of a medical device comprises the following steps. Provide a medical device having components which are adjacent to each other. a first portion of a component constructed and arranged to at least partially absorb a predetermined wavelength of energy. A second portion of a component being substantially transparent to the predetermined wavelength of energy. Transmit the predetermined wavelength of energy through the second portion and expose the first portion to the energy. The first portion being heated as a result of substantially absorbing the energy. Transmit heat from the first portion to at least one adjacent portion of the components. Melt the first portion and the at least one adjacent portion. Removing the energy from the first portion. A bond being formed between the first portion and the second portion by allowing the portions to cool together.