Patents by Inventor Brian J. Hardinge

Brian J. Hardinge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of ceramides
    Patent number: 5525709
    Abstract: The invention relates to the preparation of ceramides by a two step process involving conversion of a 2-hydroximino-3-oxo-alkanoate into a 2-alkanoylamido-3-oxo-alkanoate intermediate by acylation of the oxime and reduction of the oxime ester group to an amido group, followed by reduction of the keto and ester group of the intermediate to the 1,3 diol of the ceramide. The oxime acylation and the first reduction may be carried out consecutively or simultaneously. The first reduction is preferably a catalytic hydrogenation and the second reduction is preferably a borohydride reduction.The invention further relates to novel 2-alkanoylamido-3-oxo-alkanoates and 2-alkanoyloximino-3-oxo-alkanoates which are useful as intermediates for conversion into ceramides.
    Type: Grant
    Filed: October 4, 1994
    Date of Patent: June 11, 1996
    Assignee: Unilever Patent Holdings B.V.
    Inventors: Paul N. Davey, Brian J. Hardinge, Christopher P. Newman, Clive D. Richardson