Patents by Inventor Brian J. Rush

Brian J. Rush has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240052383
    Abstract: Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene.
    Type: Application
    Filed: October 30, 2023
    Publication date: February 15, 2024
    Applicant: CARGILL, INCORPORATED
    Inventors: Arlene M. FOSMER, Vernon L. MCINTOSH, Jr., Thomas W. MCMULLIN, Gregory M. POYNTER, Brian J. RUSH, Kevin T. WATTS
  • Patent number: 11821021
    Abstract: Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene.
    Type: Grant
    Filed: June 15, 2021
    Date of Patent: November 21, 2023
    Assignee: CARGILL, INCORPORATED
    Inventors: Arlene M. Fosmer, Vernon L. McIntosh, Jr., Thomas W. McMullin, Gregory M. Poynter, Brian J. Rush, Kevin T. Watts
  • Patent number: 11802266
    Abstract: The present invention relates to genetically engineered yeasts having a heterologous trehalase gene and fermentation processes for using such yeasts. The yeasts can express trehalase in a quantity sufficient to convert significant amounts of trehalose to glucose, thereby improving the yield of the product in a fermentation, and/or reducing or eliminating the need to add exogenous trehalase to the fermentation. The yeasts can also include other heterologous genes for expressing enzymes useful for improving yield and/or for reducing or eliminating the need to add exogenous enzymes to the fermentation.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: October 31, 2023
    Assignee: CARGILL, INCORPORATED
    Inventors: Peter Alan Jauert, Gregory Michael Poynter, Brian J. Rush
  • Publication number: 20230312253
    Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
    Type: Application
    Filed: May 19, 2023
    Publication date: October 5, 2023
    Applicant: CARGILL, INCORPORATED
    Inventors: Catherine Asleson DUNDON, Pirkko SUOMINEN, Aristos ARISTIDOU, Brian J. RUSH, Kari KOIVURANTA, Benjamin Matthew HAUSE, Thomas William McMULLIN, Kevin ROBERG-PEREZ
  • Patent number: 11691817
    Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: July 4, 2023
    Assignee: CARGILL, INCORPORATED
    Inventors: Catherine Asleson Dundon, Pirkko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
  • Publication number: 20230193299
    Abstract: The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate.
    Type: Application
    Filed: July 15, 2022
    Publication date: June 22, 2023
    Applicant: CARGILL, INCORPORATED
    Inventors: Kenneth R. FINLEY, Jeanette M. HURYTA, Beth M. MASTEL, Thomas W. McMULLIN, Gregory M POYNTER, Brian J. RUSH, Arlene M. FOSMER, Vernon L. McINTOSH, Jr., Keith M. BRADY, Kevin T. WATTS
  • Patent number: 11390873
    Abstract: The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: July 19, 2022
    Assignee: CARGILL, INCORPORATED
    Inventors: Kenneth R. Finley, Jeanette M. Huryta, Beth M. Mastel, Thomas W. McMullin, Gregory M. Poynter, Brian J. Rush, Arlene M. Fosmer, Vernon L. McIntosh, Jr., Keith M. Brady, Kevin T. Watts
  • Publication number: 20210381011
    Abstract: Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene.
    Type: Application
    Filed: June 15, 2021
    Publication date: December 9, 2021
    Applicant: CARGILL, INCORPORATED
    Inventors: Arlene M. FOSMER, Vernon L. MCINTOSH, JR., Thomas W. MCMULLIN, Gregory M. POYNTER, Brian J. RUSH, Kevin T. WATTS
  • Publication number: 20210301275
    Abstract: The present invention relates to genetically engineered yeasts having a heterologous trehalase gene and fermentation processes for using such yeasts. The yeasts can express trehalase in a quantity sufficient to convert significant amounts of trehalose to glucose, thereby improving the yield of the product in a fermentation, and/or reducing or eliminating the need to add exogenous trehalase to the fermentation. The yeasts can also include other heterologous genes for expressing enzymes useful for improving yield and/or for reducing or eliminating the need to add exogenous enzymes to the fermentation.
    Type: Application
    Filed: June 10, 2021
    Publication date: September 30, 2021
    Applicant: CARGILL, INCORPORATED
    Inventors: Peter Alan JAUERT, Gregory Michael POYNTER, Brian J. RUSH
  • Patent number: 11041218
    Abstract: The present invention relates to genetically engineered yeasts having a heterologous trehalase gene and fermentation processes for using such yeasts. The yeasts can express trehalase in a quantity sufficient to convert significant amounts of trehalose to glucose, thereby improving the yield of the product in a fermentation, and/or reducing or eliminating the need to add exogenous trehalase to the fermentation. The yeasts can also include other heterologous genes for expressing enzymes useful for improving yield and/or for reducing or eliminating the need to add exogenous enzymes to the fermentation.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: June 22, 2021
    Assignee: CARGILL, INCORPORATED
    Inventors: Peter Alan Jauert, Gregory Michael Poynter, Brian J. Rush
  • Patent number: 11041176
    Abstract: Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: June 22, 2021
    Assignee: CARGILL, INCORPORATED
    Inventors: Brian J. Rush, Kevin T. Watts, Vernon L. McIntosh, Jr., Arlene M. Fosmer, Gregory M. Poynter, Thomas W. McMullin
  • Publication number: 20210155411
    Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
    Type: Application
    Filed: January 21, 2021
    Publication date: May 27, 2021
    Applicant: Cargill, Incorporated
    Inventors: Catherine Asleson DUNDON, Pirrko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
  • Publication number: 20210062230
    Abstract: Aspects of the disclosure provide engineered microbes for ethanol production. Methods for microbe engineering and culturing are also provided herein. Such engineered microbes exhibit enhanced capabilities for ethanol production.
    Type: Application
    Filed: March 27, 2019
    Publication date: March 4, 2021
    Applicant: Cargill, Incorporated
    Inventors: Gregory M. Poynter, Brian J. Rush, Sneha Srikrishnan, Dawn Thompson, Arthur Shockley, Brynne Kohman, Joshua Dunn
  • Patent number: 10899544
    Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: January 26, 2021
    Assignee: CARGILL, INCORPORATED
    Inventors: Catherine Asleson Dundon, Pirrko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
  • Publication number: 20200377302
    Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
    Type: Application
    Filed: March 30, 2018
    Publication date: December 3, 2020
    Applicant: Cargill Incorporated
    Inventors: Catherine Asleson Dundon, Pirrko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
  • Publication number: 20200362371
    Abstract: The present invention relates to a genetically engineered yeast capable of manufacturing a fermentation product using sucrose as a fermentation substrate, and fermentation processes using such a yeast. The yeast has an exogenous invertase gene and has a deletion or disruption of the PDC activity gene. Accordingly, the yeast is useful for manufacturing fermentation products other than ethanol from fermentation substrates containing sucrose.
    Type: Application
    Filed: August 3, 2020
    Publication date: November 19, 2020
    Applicant: CARGILL, INCORPORATED
    Inventors: Arlene M. FOSMER, Peter Alan Jauert, Gregory M. Poynter, Brian J. Rush
  • Publication number: 20200270644
    Abstract: Genetically modified yeast having a heterologous sugar transporter that is capable of transporting a non-glucose sugar such as maltulose, are described. The heterologous sugar transporter can be a protein according to, or that has similarity to, SEQ ID NO:44. Fermentation methods using enzymatically treated starch where the yeast are able to consume the non-glucose sugars, are also described. The engineered yeast can be useful for producing desired bioproducts such as high ethanol, with low amounts of residual sugars in the medium.
    Type: Application
    Filed: December 16, 2016
    Publication date: August 27, 2020
    Inventors: CHRISTOPHER K. MILLER, Ana Negrete-Raymond, Brian J. Rush, Amit Vas, Jon Veldhouse
  • Patent number: 10738332
    Abstract: The present invention relates to a genetically engineered yeast capable of manufacturing a fermentation product using sucrose as a fermentation substrate, and fermentation processes using such a yeast. In some embodiments, the fermentation product is ethanol.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: August 11, 2020
    Assignee: CARGILL, INCORPORATED
    Inventors: Peter Alan Jauert, Genfeng Lu, Gregory M. Poynter, Brian J. Rush
  • Patent number: 10731184
    Abstract: The present invention relates to a genetically engineered yeast capable of manufacturing a fermentation product using sucrose as a fermentation substrate, and fermentation processes using such a yeast. The yeast has an exogenous invertase gene and has a deletion or disruption of the PDC activity gene. Accordingly, the yeast is useful for manufacturing fermentation products other than ethanol from fermentation substrates containing sucrose.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: August 4, 2020
    Assignee: CARGILL, INCORPORATED
    Inventors: Arlene M. Fosmer, Peter Alan Jauert, Gregory M. Poynter, Brian J. Rush
  • Patent number: 10655151
    Abstract: Sugar mixtures containing nonfermentable oligomers are fermented in the presence of certain enzymes that depolymerise the oligomers simultaneously with the fermentation process.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: May 19, 2020
    Assignee: Cargill, Incorporated
    Inventors: Daniel R. Beacom, Jeffrey J. Kolstad, David H. Reeder, Brian J. Rush