Patents by Inventor Brian J. Stockman

Brian J. Stockman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying ligands using competitive binding H NMR experiments
    Patent number: 7470543
    Abstract: A method of identifying a ligand to a target molecule that includes: providing a reference compound that interacts with the target molecule; collecting a 1D 1H nuclear magnetic resonance spectrum of the reference compound in the presence of the target molecule; providing a plurality of test samples, each test sample including at least one test compound; collecting a 1D 1H nuclear magnetic resonance spectrum of the reference compound in the presence of each test sample and the target molecule; comparing the spectrum of the reference compound in the presence of the target molecule to the spectrum of the reference compound in the presence of each test sample and the target molecule to determine a change in one or more of the reference compound resonances; and identifying at least one test compound that interacts with the target molecule, wherein the test compound displaces the reference compound.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: December 30, 2008
    Assignee: Nerviano Medical Sciences S.r.l.
    Inventors: Claudio Dalvit, Brian J Stockman
  • Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
    Patent number: 7377894
    Abstract: A method for developing a library of compounds, the compound library, a method for identifying ligands for target molecules, and a method for identifying lead chemical templates, which, for example, can be used in drug discovery and design are provided. Certain embodiments of these methods include the use of NMR spectroscopy.
    Type: Grant
    Filed: October 27, 2003
    Date of Patent: May 27, 2008
    Assignee: Pharmacia & Upjohn Company
    Inventors: Brian J Stockman, Kathleen A Farley
  • Methods for creating a compound library
    Patent number: 6764858
    Abstract: A method for developing a library of compounds, the compound library, a method for identifying ligands for target molecules, and a method for identifying lead chemical templates, which, for example, can be used in drug discovery and design are provided. Certain embodiments of these methods include the use of NMR spectroscopy.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: July 20, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventor: Brian J. Stockman
  • Use of fluorine NMR for high throughput screening
    Publication number: 20040091937
    Abstract: High-Throughput ligand-based NMR screening with competition binding experiments using 19F detection.
    Type: Application
    Filed: June 5, 2003
    Publication date: May 13, 2004
    Inventors: Claudio Dalvit, Brian J. Stockman, Maria Flocco, Marina Veronesi
  • Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
    Publication number: 20040086948
    Abstract: A method for developing a library of compounds, the compound library, a method for identifying ligands for target molecules, and a method for identifying lead chemical templates, which, for example, can be used in drug discovery and design are provided. Certain embodiments of these methods include the use of NMR spectroscopy.
    Type: Application
    Filed: October 27, 2003
    Publication date: May 6, 2004
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventors: Brian J. Stockman, Kathleen A. Farley, Claudio Dalvit
  • Methods for identifying ligands using competitive binding 1H NMR experiments
    Publication number: 20040072362
    Abstract: A method of identifying a ligand to a target molecule that includes: providing a reference compound that interacts with the target molecule; collecting a 1 D 1H nuclear magnetic resonance spectrum of the reference compound in the presence of the target molecule; providing a plurality of test samples, each test sample including at least one test compound; collecting a 1 D 1H nuclear magnetic resonance spectrum of the reference compound in the presence of each test sample and the target molecule; comparing the spectrum of the reference compound in the presence of the target molecule to the spectrum of the reference compound in the presence of each test sample and the target molecule to determine a change in one or more of the reference compound resonances; and identifying at least one test compound that interacts with the target molecule, wherein the test compound displaces the reference compound.
    Type: Application
    Filed: June 5, 2003
    Publication date: April 15, 2004
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventors: Claudio Dalvit, Brian J. Stockman
  • Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
    Patent number: 6677160
    Abstract: A method for developing a library of compounds, the compound library, a method for identifying ligands for target molecules, and a method for identifying lead chemical templates, which, for example, can be used in drug discovery and design are provided. Certain embodiments of these methods include the use of NMR spectroscopy.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: January 13, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Brian J. Stockman, Kathleen A. Farley, Claudio Dalvit
  • Methods for creating a compound library
    Publication number: 20020192707
    Abstract: A method for developing a library of compounds, the compound library, a method for identifying ligands for target molecules, and a method for identifying lead chemical templates, which, for example, can be used in drug discovery and design are provided. Certain embodiments of these methods include the use of NMR spectroscopy.
    Type: Application
    Filed: November 19, 2001
    Publication date: December 19, 2002
    Applicant: Pharmacia & Upjohn
    Inventors: Brian J. Stockman, Kathleen A. Farley
  • Nuclear magnetic resonance methods for identifying sites in papillomavirus E2 protein
    Publication number: 20010051333
    Abstract: Nuclear magnetic resonance methods for identifying sites in a DNA-binding and dimerization domain of a papillomavirus E2 protein are disclosed. Preferably the sites are ligand binding sites.
    Type: Application
    Filed: April 10, 2001
    Publication date: December 13, 2001
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventor: Brian J. Stockman